Microwave radiation (2.45 GHz)-induced oxidative stress: Whole-body exposure effect on histopathology of Wistar rats

Chauhan, Prem M. S.; Verma, H. N.; Sisodia, Rashmi; Kesari, Kavindra Kumar

doi:10.3109/15368378.2016.1144063

Cited by 52 publications

(47 citation statements)

References 53 publications

(53 reference statements)

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“…Several studies have demonstrated the negative impact of MW radiation exposure on male reproductive health which may affect male fertility . Reports are there mentioning the ill effects of short duration exposure to MW radiation on gonadotropin levels (FSH and LH), testicular morphology, histopathology, serum/plasma testosterone levels, sperm counts, and sperm viability . Studies demonstrate that short term exposure to 2.45 GHz MW radiation may lead to testicular apoptosis.…”

Section: Introductionmentioning

confidence: 99%

2.45 GHz microwave radiation induced oxidative and nitrosative stress mediated testicular apoptosis: Involvement of a p53 dependent bax‐caspase‐3 mediated pathway

Shahin

Singh

Chaturvedi

2018

Environmental Toxicology

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Deleterious effects of MW radiation on the male reproduction are well studied. Previous reports although suggest that 2.45 GHz MW irradiation induced oxidative and nitrosative stress adversely affects the male reproductive function but the detailed molecular mechanism occurring behind it has yet to be elucidated. The aim of present study was to investigate the underlying detailed pathway of the testicular apoptosis induced by free radical load and redox imbalance due to 2.45 GHz MW radiation exposure and the degree of severity along with the increased exposure duration. Twelve-week old male mice were exposed to 2.45 GHz MW radiation [continuous-wave (CW) with overall average Power density of 0.0248 mW/cm and overall average whole body SAR value of 0.0146 W/kg] for 2 hr/day over a period of 15, 30, and 60 days. Testicular histology, serum testosterone, ROS, NO, MDA level, activity of antioxidant enzymes, expression of pro-apoptotic proteins (p53 and Bax), anti-apoptotic proteins (Bcl-2 and Bcl-x ), cytochrome-c, inactive/active caspase-3, and uncleaved PARP-1 were evaluated. Findings suggest that 2.45 GHz MW radiation exposure induced testicular redox imbalance not only leads to enhanced testicular apoptosis via p53 dependent Bax-caspase-3 mediated pathway, but also increases the degree of apoptotic severity in a duration dependent manner.

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Section: Introductionmentioning

confidence: 99%

2.45 GHz microwave radiation induced oxidative and nitrosative stress mediated testicular apoptosis: Involvement of a p53 dependent bax‐caspase‐3 mediated pathway

Shahin

Singh

Chaturvedi

2018

Environmental Toxicology

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“…Chauhan et al [30] stated significant increase in lipid peroxidation after microwave exposure. This was explained that microwave radiation is suggested to have the potential of changing the biological lipid membranes and the outcomes of these changes can be seen in the structural and functional properties of a cell.…”

Section: Discussionmentioning

confidence: 99%

Effect of Apocynin on Liver Toxicity Induced by Microwaves in Rats

Hewady¹,

Elkholy²,

Esmaeila³

2017

Egyptian Journal of Hospital Medicine

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Background: electromagnetic waves could cause oxidative stress and generate ROS that lead to free radical production and lipid peroxidation which damage liver tissue. Apocynin (APO) exerts its antioxidant effect by reducing ROS production via inhibition of NADPH oxidase. The present study intended to demonstrate effects of microwaves exposure on hepatic pro-oxidant/antioxidant systems and to investigate protective effects of APO against microwaves induced hepatotoxicity. Aim of the work: The aim of the present work is to evaluate the effect of Apocynin on liver toxicity induced by exposure to microwaves in rats of local strain. Subjects and Methods: Thirty local strain rats were randomly assigned into three equal groups: a) control group; b) microwave exposed group (frequency of 2.45 GHz for 15 minutes once daily for a period of 16 days); c) apocynin treated prior to microwave exposure group (apocynin 20 mg/kg intraperitoneally injected 1 hour before microwave exposure and continued during the other 16 days). Liver tissue was biochemically assessed in all groups biochemically through the determination of tissue MDA, MPO, GPx and iron in liver tissue. Also, serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and Tumor necrosis factor alpha (TNFα) levels were estimated in all groups. Results: The microwave exposed group showed that there was a significant increase in serum ALT, AST, ALP, TNF-α, as well as significant increase in the level of MPO, MDA and iron in the liver tissue. However, there was a significant decrease in the GPx and zinc level in the liver tissue. These results Were estimated and calculated in comparison with those of control group. Moreover, Apocynin treated group showed a significant decrease in serum ALT, AST, ALP, TNF-α , in addition to a significant decrease in the level of MPO, MDA and iron, along with a significant increase in the GPx level in the liver tissue, as compared with microwave exposed group. Conclusion: It is possible to conclude considering the abovementioned results that apocynin has a significantly protective effect against hepatotoxicity induced by microwaves exposure.

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“…This is exactly in line with previous studies (Chen et al, 2014; Lee et al, 2005; Maaroufi et al, 2014). In addition, EMF exposure also induce oxidative stress of the brain, liver, kidney, and of testis tissues (Chauhan et al, 2017). As indicated above, some previous research failed to find negative effects resulting from EMF exposure, and even reported that EMF exposure had positive effects on spatial learning and memory (Abedi et al, 2011; Banaceur et al, 2013a).…”

Section: Discussionmentioning

confidence: 99%

Physical activity as an option to reduce adverse effect of EMF exposure during pregnancy

Dastamooz

Boroujeni

Shahbazi

et al. 2018

Intl J of Devlp Neuroscience

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The popularity of using wireless fidelity over the last decades increased apprehensions about impact of high frequency electromagnetic fields (EMF) on health. Most of previous studies mentioned adverse effect of EMF on cognitive processes, but so far, no study has provided a way to control adverse effects of EMF exposure. The purpose of this study was to examine the effect of Wi-Fi EMF and physical activity on spatial learning and motor function in pregnant rat's offspring. Forty Albino-Wistar pregnant rats divided randomly into four groups (EMF, physical activity, combined 2.4GHZ EMF and physical activity and control groups). For assessing spatial learning in 56 post-natal days' old (PND) male offspring, Morris Water Maze (MWM) was used and to examine motor function Open-field test was taken. Although results of MWM test revealed that Wi-Fi modem EMF caused impairment in spatial learning in rats exposed to EMF but physical activity could reduce negative effect of EMF in pregnant rat's offspring who exposed during pregnancy but performed swimming. In addition, results of open-field test showed that litter's motor function in EMF group significantly declined in comparison with physical activity and combined 2.4GHZ EMF and physical activity groups. According to our findings, it can be concluded that execution physical activity individually or along with wave-exposed pregnancy can significantly progressive effect on offspring' cognitive and motor functions.

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Microwave radiation (2.45 GHz)-induced oxidative stress: Whole-body exposure effect on histopathology of Wistar rats

Cited by 52 publications

References 53 publications

2.45 GHz microwave radiation induced oxidative and nitrosative stress mediated testicular apoptosis: Involvement of a p53 dependent bax‐caspase‐3 mediated pathway

2.45 GHz microwave radiation induced oxidative and nitrosative stress mediated testicular apoptosis: Involvement of a p53 dependent bax‐caspase‐3 mediated pathway

Effect of Apocynin on Liver Toxicity Induced by Microwaves in Rats

Physical activity as an option to reduce adverse effect of EMF exposure during pregnancy

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