Oxidative imbalance in bipolar disorder subtypes: A comparative study

Yumru, Mehmet; Savaş, Haluk A.; Kalenderoğlu, Aysun; Bulut, Mahmut; Çelik, Hakim; Erel, Özcan

doi:10.1016/j.pnpbp.2009.06.005

Cited by 113 publications

(96 citation statements)

References 34 publications

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“…A body of clinical evidence indicates that depression is characterized by a higher oxidant status. In fact, total oxidant status (TOS) and oxidative stress index (OSI) were increased in depressed patients as compared to normal controls in plasma [3,4] and serum [5,6]. Some studies demonstrated higher levels of plasma peroxides [7] and serum nitric oxide (NO) [5,6,[8][9][10] in depressed patients, while Ozcan and co-workers reported lowered levels of NO in depressed patients in the pre-treatment period [11].…”

Section: Psychiatric Disordersmentioning

confidence: 99%

“…There are several lines of evidence indicating that antioxidant mechanisms are disturbed during depression, namely total antioxidant capacity (TAC) [3,4,6,29], non-enzymatic antioxidant molecules [glutathione (GSH) [30], coenzyme Q10 [31], alpha-tocopherol [32] and ascorbic acid [14]] fall, while enzymatic antioxidants, like glutathione peroxidase (GSH-Px) [11,30], catalase (CAT) [5,11], and superoxide dismutase (SOD) [5,6,8,10] show a trend to fall in depressed patients. This conclusion appears to be questioned by some reports, which indicated a rise of activities of glutathione reductase (GSH-R) [25,30] and GSH-S-transferase [25] in the late stage of the illness, without alteration in GSH-Px activity [3,25].…”

Section: Psychiatric Disordersmentioning

confidence: 99%

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Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga

Niedzielska

Gawlik

et al. 2015

Pharmacological Reports

221

128

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The pathophysiology of psychiatric diseases, including depression, anxiety, schizophrenia and autism, is far from being fully elucidated. In recent years, a potential role of the oxidative stress has been highlighted in the pathogenesis of neuropsychiatric disorders. A body of clinical and preclinical evidence indicates that psychiatric diseases are characterized by higher levels of oxidative biomarkers and with lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review current knowledge on the role of the oxidative stress in psychiatric diseases, based on clinical trials and animal studies, in addition, we analyze the effects of drug-induced modulation of oxidative balance and explore pharmacotherapeutic strategies for oxidative stress reduction.

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Section: Psychiatric Disordersmentioning

confidence: 99%

Section: Psychiatric Disordersmentioning

confidence: 99%

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga

Niedzielska

Gawlik

et al. 2015

Pharmacological Reports

221

128

View full text Add to dashboard Cite

show abstract

“…To perform the calculation, the unit of TAS, mmol Trolox equivalent/L, was converted to µmol Trolox equivalent/L, and OSI was calculated as follows: OSI = [(TOS, µmol H2O2 equivalent/L)/(TAS, µmol Trolox equivalent/L) × 100] (13). We used OSI as another indicator of oxidative stress.…”

Section: Calculation Of Oxidative Stress Index (Osi)mentioning

confidence: 99%

Effects of ukrain in rats with intestinal ischemia and reperfusion

Akçılar

Akcılar

Savran

et al. 2015

Journal of Surgical Research

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“…10 Repeated injections of d-amphetamine (d-AMPH) induced hyperactivity in animals 8 by elevating extracellular dopamine, and it has been suggested as a relevant animal model of mania. [11][12][13][14][15][16][17] There is an emerging body of data suggesting that BD is associated with decreased neurotrophins (BDNF, NGF and NT-3), 18,19 an increased oxidative 20,21 and DNA damage. 22 The group that is leading the INCT-TM has proposed a new animal model of mania, focusing on both acute and prophylactic treatments.…”

Section: Methodsmentioning

confidence: 99%

Instituto Nacional de Ciência e Tecnologia em Medicina Translacional (INCT-TM): abordagens metodológicas

Hallak

Crippa

Quevedo

et al. 2010

Rev. Bras. Psiquiatr.

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Objective: Translational medicine has been described as the integrated application of innovative pharmacology tools, biomarkers, clinical methods, clinical technologies and study designs to improve the understanding of medical disorders. In medicine, translational research offers an opportunity for applying the findings obtained from basic research to every-day clinical applications. The National Science and Technology Institute for Translational Medicine is comprised of six member institutions (Universidade Federal do Rio Grande do Sul, Universidade de São Paulo-Ribeirão Preto, Universidade Federal do Rio de Janeiro, Pontifícia Universidade Católica do Rio Grande do Sul, Universidade Estadual de Santa Catarina and a core facility that serves all centers). The objectives of the project are divided into four areas: Institutional, Research, Human Resources and Technology for the Community and Productive Sector. Method: In this manuscript, we describe some of the approaches used to attain the main objectives of the National Science and Technology Institute for Translational Medicine, which include the development of 1) animal models for bipolar disorder; 2) strategies to investigate neurobehavioral function and cognitive dysfunction associated with brain disorders; 3) experimental models of brain function and behavior, neuropsychiatric disorders, cell proliferation, and cancer; 4) Simulated Public Speaking and 5) Virtual reality simulation for inducing panic disorder and agoraphobia. Conclusion: The main focus of the National Science and Technology Institute for Translational Medicine is the development of more useful methods that allow for a better application of basic research-based knowledge to the medical field. Descriptors

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Oxidative imbalance in bipolar disorder subtypes: A comparative study

Cited by 113 publications

References 34 publications

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Effects of ukrain in rats with intestinal ischemia and reperfusion

Instituto Nacional de Ciência e Tecnologia em Medicina Translacional (INCT-TM): abordagens metodológicas

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