Instituto Nacional de Ciência e Tecnologia em Medicina Translacional (INCT-TM): abordagens metodológicas

Abstract

Objective: Translational medicine has been described as the integrated application of innovative pharmacology tools, biomarkers, clinical methods, clinical technologies and study designs to improve the understanding of medical disorders. In medicine, translational research offers an opportunity for applying the findings obtained from basic research to every-day clinical applications. The National Science and Technology Institute for Translational Medicine is comprised of six member institutions (Universidade Federal do Rio Grande do Sul, Universidade de São Paulo-Ribeirão Preto, Universidade Federal do Rio de Janeiro, Pontifícia Universidade Católica do Rio Grande do Sul, Universidade Estadual de Santa Catarina and a core facility that serves all centers). The objectives of the project are divided into four areas: Institutional, Research, Human Resources and Technology for the Community and Productive Sector. Method: In this manuscript, we describe some of the approaches used to attain the main objectives of the National Science and Technology Institute for Translational Medicine, which include the development of 1) animal models for bipolar disorder; 2) strategies to investigate neurobehavioral function and cognitive dysfunction associated with brain disorders; 3) experimental models of brain function and behavior, neuropsychiatric disorders, cell proliferation, and cancer; 4) Simulated Public Speaking and 5) Virtual reality simulation for inducing panic disorder and agoraphobia. Conclusion: The main focus of the National Science and Technology Institute for Translational Medicine is the development of more useful methods that allow for a better application of basic research-based knowledge to the medical field. Descriptors

Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age

“…Over the past 10 years, there has been an exponential increase in the number of publications dealing with the effects of CBD, fostered by the discovery of additional effects of this cannabinoid ( 2 , 64 , 83 ). To take part in the frontline of research in these new areas, Brazilian groups articulated to create the National Institute of Science and Technology for Translational Medicine (INCT-TM), funded by the Brazilian National Council for Scientific and Technological Development ( CNPq ) ( 146 ). As a result of this network, we contributed with further evidence on the actions of CBD as a neuroprotector ( 147 ), an anti-inflammatory ( 148 , 149 ), and a drug able to increase sleep periods ( 150 ), among other properties ( 151 – 157 ).…”

Panic attack triggering myocardial ischemia documented by myocardial perfusion imaging study. A case report

“…There is no doubt about the ability of a PA to act as a powerful mental stressor. Based on translational medicine objectives [36] of an integrated application of innovative tools, clinical methods, and technologies to improve the understanding of medical disorders, the use of CO2 challenge followed by Sestamibi SPECT could be a useful method to allow improved application of research-based knowledge to the medical field, specifically at the interface of PD and cardiovascular disease.…”

Uso de sustancias psicoactivas como tratamiento de la psicosis

“…En cuanto a los síntomas cognitivos, el grupo placebo obtuvo mejoras en inteligencia y razonamiento y resolución de problemas [ 51 ]. Sin embargo, esto podría deberse a la cantidad de cannabidiol administrada, ya que con dosis de 300 mg sucedía la mejora cognitiva, pero, si la dosis era de 600 mg, ocurría un empeoramiento cognitivo [ 55 ]. Por otro lado, es importante destacar que en una muestra donde se administraron 1.000 mg de cannabidiol se encontraron mejoras significativas en la velocidad motora y una mejora no significativamente mayor en las funciones ejecutivas [ 60 ].…”