Oxidative damage markers as possible discriminatory biomarkers in breast carcinoma

Pande, Deepti; Negi, Reena; Karki, Kanchan; Khanna, Seema; Khanna, Ranjana S.; Khanna, Hari D.

doi:10.1016/j.trsl.2012.07.005

Cited by 28 publications

(21 citation statements)

References 35 publications

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“…Correlation analysis yielded that serum 8-OHdG levels were correlated negatively with TAS levels whereas positively with OSI and LOOH levels in preoperative patients. Karki and Pande et al showed a negative correlation between 8-OHdG and TAS levels in malignant breast diseases similar to our study [30,23]. This is the first study evaluating serum 8-OHdG and many oxidative stress markers in both preoperative and postoperative papillary thyroid cancer patients.…”

Section: Discussionsupporting

confidence: 89%

“…The poor enzymatic and non-enzymatic antioxidant system may be a reason for increased oxidative damage to DNA in the serum of patients with papillary cancer. This may also be due to excessive generation of DNA damage products in cancer tissue and subsequent release of these products 8-OHdG (ng/dl) 15 [23][24][25]. Furthermore, we also found that 8-OHdG levels were higher in stage 4 patients than in early stages, but it was not statistically significant.…”

Section: Discussionmentioning

confidence: 71%

“…Serum LOOH levels were significantly higher in the preoperative and postoperative groups compared with controls in our study. Lipid peroxidation end products have been found to be elevated in various cancers [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

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Investigation of the role of 8-OHdG and oxidative stress in papillary thyroid carcinoma

et al. 2014

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The aim of this study was to determine levels of serum 8-hydroxy-2'-deoxyguanosine (8-OHdG) as an indicator of oxidant-induced DNA damage and oxidant status in patients with papillary thyroid carcinoma before and after surgery. This study included 25 patients with papillary thyroid carcinoma and age-matched 27 healthy controls. Total antioxidant status (TAS), total oxidant status (TOS), lipid hydroperoxide (LOOH), and 8-OHdG levels were measured. 8-OHdG levels were significantly higher in the preoperative papillary thyroid carcinoma (PTC) group compared with the healthy control group (p < 0.001) and were significantly lower after operation in patients with papillary thyroid carcinoma (p = 0.004). Oxidative stress index (OSI) levels were significantly higher in both preoperative and postoperative PTC patients compared with the healthy control group (p < 0.001 and p < 0.001, respectively). TOS levels were higher in the preoperative and postoperative PTC groups compared to the healthy control group (p < 0.001 and p < 0.001, respectively). TAS levels was lower in the preoperative PTC groups compared to the healthy control group (p = 0.011). Serum LOOH levels were higher in both preoperative and postoperative PTC groups compared to the healthy control group (p < 0.001 and p < 0.001, respectively). Correlation analysis yielded that serum 8-OHdG levels were positively correlated with OSİ and LOOH levels in patients with PTC before surgery (r = 0.668, p < 0.001; r = 0.446, p = 0.025, respectively) and had a negative correlation with TAS levels (r = -0.616, p = 0.001). We have shown severe oxidative DNA damage and impaired antioxidant status in papillary thyroid carcinoma.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 71%

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Investigation of the role of 8-OHdG and oxidative stress in papillary thyroid carcinoma

et al. 2014

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“…However, ROS are difficult to measure with standard biochemical techniques due to their high reactivity and short half-life. Therefore, surrogate markers are required and MDA is commonly used as a biomarker of oxidative stress for various pathological conditions and diseases, including cancers [15,24,29,30]. …”

Section: Discussionmentioning

confidence: 99%

Oxidative stress in cancer-bearing dogs assessed by measuring serum malondialdehyde

et al. 2013

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BackgroundOxidative stress, an excess of reactive oxygen species (ROS), causes lipid peroxidation resulting in cell and tissue damages. It may be associated with the development and progression of cancers in dogs. Malondialdehyde (MDA), the end product of lipid peroxidation, is commonly used as a marker of oxidative stress. The objective of this study was to assess oxidative stress in cancer-bearing dogs by measuring serum MDA levels. All client-owned dogs underwent physical examination at the Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Khon Kaen University to determine the health status with the owner’s consent. Blood samples of cancer-bearing dogs (N = 80) and clinically normal dogs (N = 101) were obtained and subjected for determination of MDA levels. In addition, complete blood count, creatinine, and alanine aminotransferase were measured.ResultsSerum MDA was significantly higher in cancer-bearing dogs than in clinically normal dogs (mean ± SD, 4.68 ± 1.32 μmol/L vs 2.95 ± 0.61 μmol/L, respectively; p < 0.001). Packed cell volume (mean ± SD, 36.18 ± 7.65% vs 44.84 ± 5.54%), hemoglobin (mean ± SD, 11.93 ± 2.88 g% vs 15.17 ± 2.00 g%) and red blood cells (median (IQA), 6.05 (2.15) vs 8.09 (1.34)) were all significantly lower in cancer-bearing dogs than in clinically normal dogs. However, the reverse was true for white blood cells (median (IQA), 18.20 (11.95) vs 14.90 (5.10)). Neither creatinine nor alanine aminotransferase levels were significantly different between groups.ConclusionsThis study supports the conclusion that oxidative stress is associated with many types of cancers in dogs, as serum MDA levels were significantly higher in cancer-bearing dogs compared to clinically normal dogs.

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“…MDA, a well-characterized mutagen, was found to increase significantly in the breast cancer patients compared with benign and controls and these levels were found to increase with the progression of disease, tumor size, and presence of lymph node. In our earlier studies, we have reported an elevated level of this oxidatively modified biomolecule/s in breast carcinogenesis and benign breast diseases which might be involved in the patho-physiology of breast cancer formation [26,27]. Several lines of evidence have suggested that one of the major influences on breast carcinogenesis is oxidative stress [28].…”

Section: Discussionmentioning

confidence: 99%

Correlation of serum toll like receptor 9 and trace elements with lipid peroxidation in the patients of breast diseases

Karki

Pande

Negi

et al. 2015

Journal of Trace Elements in Medicine and Biology

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Oxidative damage markers as possible discriminatory biomarkers in breast carcinoma

Cited by 28 publications

References 35 publications

Investigation of the role of 8-OHdG and oxidative stress in papillary thyroid carcinoma

Investigation of the role of 8-OHdG and oxidative stress in papillary thyroid carcinoma

Oxidative stress in cancer-bearing dogs assessed by measuring serum malondialdehyde

Correlation of serum toll like receptor 9 and trace elements with lipid peroxidation in the patients of breast diseases

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