Oxidation of a Anticholinergic Drug Atropine Sulfate Monohydrate by Alkaline Copper(III) Periodate Complex: A Kinetic and Mechanistic Study

Abstract

The oxidation of a anticholinergic drug, Atropine sulfate monohydrate (ASM) by diperiodatocuprate(III) (DPC) has been investigated spectrophotometrically in aqueous alkaline medium at a constant ionic strength of 0.50 mol dm-3. The reaction between diperiodatocuprate(III) and atropine sulfate exhibits 1:2 stoichiometry (atropine sulfate: diperiodatocuprate(III)). The main oxidation products were identified and confirmed by spectral studies including IR, 1H NMR and GC-MS. A suitable mechanism is proposed. The order with respect to diperiodatocuprate(III) concentration was unity, while the order with respect to atropine sulfate concentration was less than unity over the concentration range studied. The rates increased with an increase in alkali concentration and decreased with an increase in periodate concentration. The activation parameters with respect to slow step of the mechanism were calculated and the thermodynamic quantities we are also determined. Kinetic experiments suggest that [Cu(OH)2(H3IO6)] - is the reactive species of copper(III).

Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study

“…Although some reports on the oxidation of atropine by some oxidants have been published [22][23][24][25][26], there is a lack of literature on the kinetics of oxidation of this drug by permanganate ion in acid solutions. This observation prompted us to investigate the title reactions.…”

Spectroscopic investigation and oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media: a mechanistic approach

“…9 Its degradation by microorganisms has been reported by several groups 10,11 and, in cases for * Correspondence: schimatadar@gmail.com which the mechanism has been studied, hydrolysis of the ester linkage to give the 2 separate cyclic components is the initial step. 12 Although some work on oxidation of atropine sulfate monohydrate by various oxidants has been carried out, 12 there is a lack of literature on the oxidation of this drug by hexacyanoferrate(III). The objectives of the present study were to (i) accumulate the kinetic data, (ii) elucidate plausible mechanisms, (iii) design kinetic rate laws, (iv) ascertain the reactive species, (v) deduce thermodynamic parameters, and (vi) characterize the products.…”