Oxidant and Antioxidant Status in Children With Subacute Sclerosing Panencephalitis

Abstract

We analyzed serum alpha-tocopherol, beta-carotene, retinol, and ascorbic acid levels and malondialdehyde and reduced glutathione concentrations on erythrocyte and cerebrospinal fluid in 30 patients with subacute sclerosing panencephalitis to evaluate oxidant and antioxidant status. Serum alpha-tocopherol, beta-carotene, retinol, ascorbic acid levels, and erythrocyte and cerebrospinal fluid reduced glutathione concentrations were decreased; however, erythrocyte and cerebrospinal fluid malondialdehyde levels were increased in the patients. Cerebrospinal fluid malondialdehyde levels were different between clinical stages of the disease (P < .05). Higher cerebrospinal fluid malondialdehyde level was associated with the more severe clinical stage. A positive correlation was found between cerebrospinal fluid malondialdehyde level and clinical stages (r = 0.42; P < .05) and between erythrocyte malondialdehyde level and clinical stages (r = 0.40; P < .05). Our findings showed presence of oxidative damage in subacute sclerosing panencephalitis and that antioxidants were increased as defense mechanisms of the organism against oxidative damage.

In vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesions

“… 2010 ; Caksen et al. 2014 ) When ROS production accumulates and exceeds over the cellular antioxidant system, oxidative stress occurs (Aslan et al. 2012 ) Lipid peroxidation, an outcome of ROS reaction against cell membrane, generates extreme lipid peroxidation products such as MDA, causing oxidative gastric damage.…”

“… 2013 ; Caksen et al. 2014 ). Retinol plays an important antioxidant role in biological systems, as well.…”

Expression Patterns of Micro-RNAs 146a, 181a, and 155 in Subacute Sclerosing Panencephalitis

“…12,13 Lipid peroxidation and oxidative stress are also well-known causes of neurodegeneration in subacute sclerosing panencephalitis. 7,29 Thus, increased expression of micro-RNA 181a in patients may also be a sign of apoptosis and increased oxidative stress.…”

Oxidative Stress and Overview of Pediatric Disease Biomarkers

“…6,[27][28][29][30] Certain drugs such as analgesic, anticancer drugs may also contribute tissue damage by increasing oxidative stress. [31][32][33] Oxidative stress biomarkers have been measured in cerebrospinal fluid, joint fluid, 34 nasal lavage fluid, 35 several types of tissues, 11,12,[36][37][38] or combination with blood or urine samples. [39][40][41] Oxidative stress levels were conventionally measured by some analytical techniques including high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS).…”