Oxidative Stress and Overview of Pediatric Disease Biomarkers

Ayaz, Ahmet

doi:10.1055/s-0035-1554784

Cited by 4 publications

(3 citation statements)

References 56 publications

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“…Thus, zinc acts as a potent agent by inhibition of ROS production and inflammation. The oxidative stress in pediatric diseases causes an oxidative burst that result in a respiratory burst and rapid ROS production, including superoxide and hydrogen peroxide [38]. However, ROS production in zinc(Ⅱ)-immune pediatric patient with COVID-19 bronchitis and pneumonia cannot be elucidated yet.…”

Section: Zinc-induced Ros Generation In Covid-19 Bronchitis Pneumonia and Thrombosismentioning

confidence: 99%

Zn2+ Ions-Induced Immune Pediatric Anti-Respiratory, Anti-Pulmonary, and Anti-Thrombotic Activities During ROS Generation Against Severe COVID-19 Infection, and its Zn2+-Binding Proteins Molecular Mechanism

Ishida¹

2021

UJPT

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Volume 1 Issue 3-2021 Mini Review children. Zinc supplementation have been assessed, from 15 mg to 140 mg/week, with the upper range exceeding the Recommended Daily Infection (RDI) for children of 2 mg/day for children less than one year of age and up to 7 mg/day for children between 1 to 3 years.Zinc induced Reactive Oxygen Species (ROS) generation and oxidative stress in COVID-19 bronchitis, pneumonia and thrombosis in children that are caused by mRNA degradation and oxidative respiratory burst, and thrombosis revoluted by tissue damage and ROS resolve venous thrombus. By rapid ROS production, the oxidative stress in pediatric diseases causes an oxidative and a respiratory burst.Thus, Zinc(Ⅱ) ions-induced immune antiviral and antithrombotic molecular mechanisms may be caused that Zn2+ ions are bound with COVID-19 surface proteins molecules, such as S (spike), E (envelope), M (membrane) and N (nucleocapsid) proteins and with coagulated thrombus protein by Zn2+ ion-coordinated tetrahedrally or Zn2+ triad binding structure formation.

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Section: Zinc-induced Ros Generation In Covid-19 Bronchitis Pneumonia and Thrombosismentioning

confidence: 99%

Zn2+ Ions-Induced Immune Pediatric Anti-Respiratory, Anti-Pulmonary, and Anti-Thrombotic Activities During ROS Generation Against Severe COVID-19 Infection, and its Zn2+-Binding Proteins Molecular Mechanism

Ishida¹

2021

UJPT

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“…Thus, zinc acts as a potent agent by inhibition of ROS production and inflammation [23]. The oxidative stress in pediatric diseases causes an oxidative burst that results in a respiratory burst and rapid ROS production, including superoxide and hydrogen peroxide [24]. However, ROS production in zinc(Ⅱ)-immune pediatric patient with COVID-19 bronchitis and pneumonia cannot be elucidated yet.…”

Section: Zinc-induced Ros Generation In Covid-19 Respiratory Ailment mentioning

confidence: 99%

Zn2+ Ions-Immune Virucidal activities for children and adults with preventions against 2019-nCoV and COVID-19 infection

Ishida¹

2020

J Child Adult Vaccines Immunol

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Zinc induced pediatric preventing respiratory 2019-nCoV is required that supplementation with zinc gluconate 20 mg in Zn deficient children resulted in a nearly twofold reduction of acute lower respiratory infections as well as the time to recovery. Zinc supplementation in children is associated with a reduction in the incidence and prevalence of pneumonia. Preventing 2019-nCoV pneumonia is required that zinc supplementation alone (10 to 20 mg) for more than 3 months significantly reduces in the rate of pneumonia. zinc pediatric intake may be required to be effective range 10～20 mg/d for 2019-CoV prevention, 10～30 mg/d for reduction of COVID-19 bronchitis, and 20～30 mg/d for recovery from COVID-19 pneumonia, in which Zn2+ could bind with viral surface proteins by Zn2+ions-centered tetrahedrally coordination pattern. On the other hand, for aults, the zinc-homeostatic immune concentration may provide a protective role against the COVID-19 pandemic, likely by improving the host’s resistance against viral infection. 50 mg of zinc per day might provide an additional shield against the COVID-19 pandemic, possibly by increasing the host resistance to viral infection to minimize the burden of the disease. In order to prevent that an outbreak of respiratory sickness caused by a novel coronavirus (COVID-19) has become a serious public threat and disrupted many lives,assessing the efficacy of FDA-approved Zn-ejector drugs such as disulfiram combined with interferon to treat COVID-19 infected patients has been proposed. The key strategies for preventing lung damages include avoiding direct lung infection, altering host-virus interactions, promoting immune responses, diluting virus concentrations in lung tissues by promoting viral migration to the rest of the body, maintaining waste removal balance, protecting heart function and renal function, avoiding other infections, reducing allergic reactions and anti-inflammatory. The interactions had been found on the binding specificity by Zn2+ ions-centered tetrahedral geometric coordination of the inhibitors against 3C and 3C-like proteases. In addition, transient zinc chelation TPEN and EPDTC have been noted as preventing virus replication. Zinc-induced ROS production in COVID-19 respiratory ailment and pneumonia occurs both in children and adults. In children. ROS production in zinc (Ⅱ)-immune pediatric patient with COVID-19 bronchitis and pneumonia cannot be elucidated yet. In adults, zinc induced ROS generation in pulmonary COVID-19 infected cells is that alterations of ROS-producing and scavenging pathways that are caused by respiratory viral infections are implicated in inﬂammation, lung epithelial disruption, and tissue damage, and, in some cases, even pulmonary ﬁbrosis. The involvement of oxidative stress in cell deaths caused during RNA virus infection and ROS production is correlated with host cell death.

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“…Thus, zinc acts as a potent agent by inhibition of ROS production and inflammation [27]. The oxidative stress in pediatric diseases causes an oxidative burst that results in a respiratory burst and rapid ROS production, including superoxide and hydrogen peroxide [28]. However, ROS production in zinc (Ⅱ)-immune pediatric patient with COVID-19 bronchitis and pneumonia cannot be elucidated yet.…”

Section: Zinc-induced Ros Generation In Covid-19 Respiratory Ailment and Pneumoniamentioning

confidence: 99%

Zinc (?)-immune pediatric virucidal activities for 2019-nCoV prevention and therapeutic effects of COVID-19 bronchitis and pneumonia

Ishida¹

2020

BRCR

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Zinc (Ⅱ)-immune pediatric virucidal activities for children with 2019-nCoV prevention and COVID-19 bronchitis and pneumonia are discussed, and these Zn2+-immune pediatric virucidal effects result in the following. Zinc intakes by zinc induced immunity are required 3 mg/day for 7 month to 3 years, 5 mg/day for 4～ 8 years, and 8 mg/day for 9 ～13 years in children. Zinc supplementation have been assessed, from 15 mg to 140 mg/week, with the upper range exceeding the recommended daily infection (RDI) for children of 2 mg/day for children less than one year of age and up to 7 mg/day for children between 1 to 3 years. Zinc induced pediatric preventing respiratory 2019-nCoV is required that supplementation with zinc gluconate 20 mg in Zn deficient children resulted in a nearly twofold reduction of acute lower respiratory infections as well as the time to recovery. Zinc supplementation in children is associated with a reduction in the incidence and prevalence of pneumonia. Preventing 2019-nCoV pneumonia is required that zinc supplementation alone (10 to 20 mg) for more than 3 months significantly reduces in the rate of pneumonia. Prophylactic zinc supplementation for two weeks may reduce the morbidity due to acute lower respiratory infections. Zinc gluconate supplement may result in significant reduction in respiratory morbidity among children with acute lower respiratory infections. In addition. as serum zinc level of Acute Respiratory Infection (ARI)-children was very low, higher zinc concentration treatments as low sociodemographic factors, poor nutritional status and male children were prevalently associated with higher incidence of acute respiratory infections. Adjuvant treatment with 20 mg zinc/day accelerates recovery from severe pneumonia in children. Primary outcome was recovery from pneumonia and 30 mg/day of zinc supplementation reduces pneumonia in children with chronic kidney disease (CKD). Zinc supplementation + Chloroquine (CQ)/hydroxychloroquine (HCQ) may be more effective in reducing COVID-19 morbidity and mortality than CQ or HCQ in monotherapy. The serum zinc level returned to a normal level (median, 53.20 μmol/L) on day 12±2 in the treatment. There was no statistical difference in the pediatric critic illness score, lung injury score, length of hospital stay, and duration of mechanical ventilation between the zinc treatments. The oxidative stress in pediatric diseases causes an oxidative burst that results in a respiratory burst and rapid ROS production. Thus, zinc pediatric intake may be required to be effective range 10～20 mg/d for 2019-CoV prevention, 10～30 mg/d for reduction of COVID-19 bronchitis, and 20～30 mg/d for recovery from COVID-19 pneumonia, in which Zn2+ could bind with viral surface proteins by Zn2+ions-centered tetrahedrally coordination pattern.

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Oxidative Stress and Overview of Pediatric Disease Biomarkers

Cited by 4 publications

References 56 publications

Zn2+ Ions-Induced Immune Pediatric Anti-Respiratory, Anti-Pulmonary, and Anti-Thrombotic Activities During ROS Generation Against Severe COVID-19 Infection, and its Zn2+-Binding Proteins Molecular Mechanism

Zn2+ Ions-Induced Immune Pediatric Anti-Respiratory, Anti-Pulmonary, and Anti-Thrombotic Activities During ROS Generation Against Severe COVID-19 Infection, and its Zn2+-Binding Proteins Molecular Mechanism

Zn2+ Ions-Immune Virucidal activities for children and adults with preventions against 2019-nCoV and COVID-19 infection

Zinc (?)-immune pediatric virucidal activities for 2019-nCoV prevention and therapeutic effects of COVID-19 bronchitis and pneumonia

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