Oxandrolone Augmentation of Resistance Training in Older Women

Mavros, Yorgi; O’Neill, Evelyn F.; Connerty, Maureen; Bean, Jonathan F.; Broe, Kerry E; Kiel, Douglas P.; MacLean, David B.; Taylor, Ann M.; Fielding, Roger A.; Singh, Maria A. Fiatarone

doi:10.1249/mss.0000000000000690

Cited by 18 publications

(16 citation statements)

References 32 publications

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“…This was considerable higher than the effect of the present study (LBM changes: WB-EMS 0.72 kg, WB-EMS&P 0.63 kg); however, in the older study fraction of this meta-analysis, the gains were much lower than the average. In an extreme case of combining high intensity resistance exercise for 12 weeks with anabolic steroids (oxandrolone), Mavros et al [43] observed a 2.6 kg (95 % CI 1.0-4.2 kg) gain in LBM in pre-frail older women (75 ± 7 year). Furthermore, body fat decreased significantly in this oxandrolone group (1.0 kg; 0.4 to 1.6 kg), while the placebo-controlled resistance exercise group of Mavros [43] gained fat mass (0.5 kg) and showed only slight increments of LBM (0.4 kg).…”

Section: Discussionmentioning

confidence: 99%

Whole-body electromyostimulation to fight sarcopenic obesity in community-dwelling older women at risk. Resultsof the randomized controlled FORMOsA-sarcopenic obesity study

Kemmler¹,

Teschler²,

Weißenfels³

et al. 2016

Osteoporos Int

153

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Section: Discussionmentioning

confidence: 99%

Whole-body electromyostimulation to fight sarcopenic obesity in community-dwelling older women at risk. Resultsof the randomized controlled FORMOsA-sarcopenic obesity study

Kemmler¹,

Teschler²,

Weißenfels³

et al. 2016

Osteoporos Int

153

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show abstract

“…Intraperitoneal administration of the newly developed mitochondria-targeted ROS and electron scavenger, XJB-5-131, reversed age-related mitochondrial function alterations and improved contractile properties in skeletal muscle [137]. Oxandrolone improved body composition adaptations to 12 weeks exercise in older women without however increasing muscle function or functional performance beyond that of exercise alone [138]. The benefits of low level laser therapy as an intervention to enhance muscle performance in the elderly is under investigation [139].…”

Section: Perspectives For Futurementioning

confidence: 99%

Skeletal muscle aging: influence of oxidative stress and physical exercise

et al. 2017

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Skeletal muscle abnormalities are responsible for significant disability in the elderly. Sarcopenia is the main alteration occurring during senescence and a key public health issue as it predicts frailty, poor quality of life, and mortality. Several factors such as reduced physical activity, hormonal changes, insulin resistance, genetic susceptibility, appetite loss, and nutritional deficiencies are involved in the physiopathology of muscle changes. Sarcopenia is characterized by structural, biochemical, molecular and functional muscle changes. An imbalance between anabolic and catabolic intracellular signaling pathways and an increase in oxidative stress both play important roles in muscle abnormalities. Currently, despite the discovery of new targets and development of new drugs, nonpharmacological therapies such as physical exercise and nutritional support are considered the basis for prevention and treatment of age-associated muscle abnormalities. There has been an increase in information on signaling pathways beneficially modulated by exercise; nonetheless, studies are needed to establish the best type, intensity, and frequency of exercise to prevent or treat age-induced skeletal muscle alterations.

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“…Nandrolone (19-nortestosterone) is an anabolic steroid which through activation of Notch signaling reduces muscle atrophy in sarcopenia rat model [151] . Furthermore, administration oxandrolone in combination with progressive resistance training improved body composition in elderly women [239] . In addition, non-steroidal selective androgen receptor modulators (SARMs) represent therapeutics for the treatment of sarcopenia.…”

Section: Sex Steroid Hormones Therapy For Sarcopeniamentioning

confidence: 97%

The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia

Kim

Tamadon

Park

et al. 2016

Osteoporosis and Sarcopenia

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Sex steroids influence the maintenance and growth of muscles. Decline in androgens, estrogens and progesterone by aging leads to the loss of muscular function and mass, sarcopenia. These steroid hormones can interact with different signaling pathways through their receptors. To date, sex steroid hormone receptors and their exact roles are not completely defined in skeletal and smooth muscles. Although numerous studies focused on the effects of sex steroid hormones on different types of cells, still many unexplained molecular mechanisms in both skeletal and smooth muscle cells remain to be investigated. In this paper, many different molecular mechanisms that are activated or inhibited by sex steroids and those that influence the growth, proliferation, and differentiation of skeletal and smooth muscle cells are reviewed. Also, the similarities of cellular and molecular pathways of androgens, estrogens and progesterone in both skeletal and smooth muscle cells are highlighted. The reviewed signaling pathways and participating molecules can be targeted in the future development of novel therapeutics.

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Oxandrolone Augmentation of Resistance Training in Older Women

Abstract: Oxandrolone improves body composition adaptations to PRT in older women over 12 wk without augmenting muscle function or functional performance beyond that of PRT alone.

Cited by 18 publications

References 32 publications

Whole-body electromyostimulation to fight sarcopenic obesity in community-dwelling older women at risk. Resultsof the randomized controlled FORMOsA-sarcopenic obesity study

Whole-body electromyostimulation to fight sarcopenic obesity in community-dwelling older women at risk. Resultsof the randomized controlled FORMOsA-sarcopenic obesity study

Skeletal muscle aging: influence of oxidative stress and physical exercise

The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia

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