The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia

Kim, Yong Jin; Tamadon, Amin; Park, Hyun Tae; Kim, Hoon; Ku, Seung‐Yup

doi:10.1016/j.afos.2016.06.002

Cited by 45 publications

(39 citation statements)

References 270 publications

(321 reference statements)

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“…At a molecular level, the action of T3 on the expression of myogenic genes, MyoD and Myogenin, has been clearly established suggesting T3 will drive myogenesis in engineered muscles [ 61 , 62 ]. The effects of progesterone on skeletal muscle remain relatively unexamined, with the expression of progesterone receptors yet to be confirmed in myoblasts [ 63 ]. Finally, corticosterone, which has only a limited role in humans with its ortholog cortisol being the predominant corticosteroid, drives skeletal muscle atrophy and inhibits insulin signalling in vivo and may perform a similar function in culture [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Bioengineered human skeletal muscle capable of functional regeneration

et al. 2020

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Background Skeletal muscle (SkM) regenerates following injury, replacing damaged tissue with high fidelity. However, in serious injuries, non-regenerative defects leave patients with loss of function, increased re-injury risk and often chronic pain. Progress in treating these non-regenerative defects has been slow, with advances only occurring where a comprehensive understanding of regeneration has been gained. Tissue engineering has allowed the development of bioengineered models of SkM which regenerate following injury to support research in regenerative physiology. To date, however, no studies have utilised human myogenic precursor cells (hMPCs) to closely mimic functional human regenerative physiology. Results Here we address some of the difficulties associated with cell number and hMPC mitogenicity using magnetic association cell sorting (MACS), for the marker CD56, and media supplementation with fibroblast growth factor 2 (FGF-2) and B-27 supplement. Cell sorting allowed extended expansion of myogenic cells and supplementation was shown to improve myogenesis within engineered tissues and force generation at maturity. In addition, these engineered human SkM regenerated following barium chloride (BaCl2) injury. Following injury, reductions in function (87.5%) and myotube number (33.3%) were observed, followed by a proliferative phase with increased MyoD+ cells and a subsequent recovery of function and myotube number. An expansion of the Pax7+ cell population was observed across recovery suggesting an ability to generate Pax7+ cells within the tissue, similar to the self-renewal of satellite cells seen in vivo. Conclusions This work outlines an engineered human SkM capable of functional regeneration following injury, built upon an open source system adding to the pre-clinical testing toolbox to improve the understanding of basic regenerative physiology.

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Section: Discussionmentioning

confidence: 99%

Bioengineered human skeletal muscle capable of functional regeneration

et al. 2020

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“…Hormonal alterations that contribute to sarcopenia are usually represented by a resistance to hormonal factors for anabolic and catabolic activities. According to Kim et al (2016), in general, steroid sex hormones have four main roles in skeletal muscle regulation: 1) regulate muscle cell metabolism, 2) promote muscle strength, 3) promote muscle growth, 4) promote muscle repairment. The effects of steroid sex hormones on the function of muscle cells are varied, dependent on gender, muscle cell types and sensitivity, and muscle position.…”

Section: Hormonal Factorsmentioning

confidence: 99%

“…Polyphenols from Aegle marmelos (Nallamuthu et al, 2014), curcumin from Curcuma longa (Receno et al, 2019), and extract of Schizandra chinensis (Kim et al, 2016) have protective effects that can prevent oxidative damage in skeletal muscle. Aegle marmelos has antioxidant properties and induces the upregulation of endogenous antioxidant enzyme in BALB/c mice.…”

Section: Prevent Oxidative Damagementioning

confidence: 99%

The Aging of Skeletal Muscle and Potential Therapeutic Effects of Extracts from Edible and Inedible Plants

Alfarafisa

Kitaguchi

Yabe

2020

RAS

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Sarcopenia is a degenerative phenomenon, common in elderly populations. As humans age, they are likely to experience skeletal muscle weakness and atrophy; however, unfortunately, there is still no effective treatment for sarcopenia. The health-promoting potential of plant-based foods is associated with the presence of bioactive components. This article reviews information on bioactive plant compounds which may affect skeletal muscle health, particularly with respect to therapeutic approaches to sarcopenia. In general, plant products can be categorized into two main groups, based on their general status in the human diet: inedible or edible. Investigations suggest that bioactive compounds from both groups show the potential to prevent the development of sarcopenia, in several ways, including anti-atrophy, prevention of oxidative damage, enhanced myogenesis, and anti-inflammatory activity. Each of these agents has been shown to suppress one or more of the signs of sarcopenia, and restore health to muscle, in the patient (in vivo) or in tissue culture (in vitro). The potential use of plant bioactive compounds as therapy for sarcopenia is worthy of further study.

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“…The biological differences between men and women contribute to several sex-specific features. Many of those differences are largely due to sex steroid hormone fluctuations, especially estrogens and progestogens [ 1 ]. Both endogenous estrogens and progestogens fluctuate predictably across the menstrual cycle (MC) in naturally eumenorrheic women [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Bidirectional Interactions between the Menstrual Cycle, Exercise Training, and Macronutrient Intake in Women: A Review

et al. 2021

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Women have a number of specificities that differentiate them from men. In particular, the role of sex steroid hormones and the menstrual cycle (MC) significantly impact women’s physiology. The literature has shown nonlinear relationships between MC, exercise, and nutritional intake. Notably, these relationships are bidirectional and less straightforward than one would suppose. For example, the theoretical implications of the MC’s phases on exercise performance do not always translate into relevant practical effects. There is often a disconnect between internal measures (e.g., levels of hormone concentrations) and external performance. Furthermore, it is not entirely clear how nutritional intake varies across the MC’s phases and whether these variations impact on exercise performance. Therefore, a thorough review of the existing knowledge could help in framing these complex relationships and potentially contribute to the optimization of exercise prescription and nutritional intake according to the naturally occurring phases of the MC. Throughout this review, an emerging trend is the lack of generalizability and the need to individualize interventions, since the consequences of the MC’s phases and their relationships with exercise and nutritional intake seem to vary greatly from person to person. In this sense, average data are probably not relevant and could potentially be misleading.

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The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia

Cited by 45 publications

References 270 publications

Bioengineered human skeletal muscle capable of functional regeneration

Bioengineered human skeletal muscle capable of functional regeneration

The Aging of Skeletal Muscle and Potential Therapeutic Effects of Extracts from Edible and Inedible Plants

Bidirectional Interactions between the Menstrual Cycle, Exercise Training, and Macronutrient Intake in Women: A Review

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