Skeletal muscle aging: influence of oxidative stress and physical exercise

Gomes, Mariana Janini; Martinez, Paula Felippe; Pagan, Luana Urbano; Damatto, Ricardo Luiz; Cezar, Marcelo; Lima, A. R. R.; Okoshi, Katashi; Okoshi, Marina Politi

doi:10.18632/oncotarget.14670

Cited by 201 publications

(151 citation statements)

References 144 publications

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“…The same stresses cause small disturbances in a suitable person of the same age. Many different body systems become dislocated on anatomical, molecular and physiological levels when people get older [11]. Some of these systemic changes are more apparent in people who are psychophysically fragile.…”

Section: Sarcopeniamentioning

confidence: 99%

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Sarcopenia and Exercise “The State of the Art”

Musumeci

2017

JFMK

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Skeletal muscle mass reduction might be a consequence of aging (sarcopenia), disease (cachexia) or inactivity (muscle atrophy). Studying the triggering factors leading to muscle loss is important in developing therapies to preserve muscle tissue function. The loss of skeletal muscle proteins is caused by an imbalance between the rate of their synthesis and degradation. Specifically, the conditions characterized by muscle loss involve an adaptation metabolism of increased protein degradation (cachexia), decreased muscle protein synthesis (inactivity), or alteration in both (sarcopenia). Sarcopenia and exercise is the main topic chosen for this review. This is a huge health problem, poorly discussed in the current literature and the aim of this review is to explain and help readers to better understand the differences between "sarcopenia", "cachexia", "muscle atrophy" and the relative beneficial effects of exercise used as a possible therapeutic intervention. Sarcopenia is a component of the fragility syndrome and indicates a significant health issue related to the progressive decline of muscle tissue quality and strength. Exercise is associated with improved life quality, reduced health problems, and prolonged lifespan. The latter suggests that exercise should be considered a fundamental point in the treatment of pathological skeletal muscle mass reduction. The present scientific contribution also seeks to emphasize to the scientific community the positive effects of the adapted physical activity in the elderly as a possible non-pharmacologic treatment to prevent or treat muscle atrophy.

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Section: Sarcopeniamentioning

confidence: 99%

“…Studies have linked fragility to increased inflammation and blood clotting activity. There is a decline in humoral and cell-mediated immunity with age advancement [11]. There is also overexpression of cytokines, decreased levels of hormones, loss of muscle mass, muscle strength or sarcopenia [12].…”

Section: Sarcopeniamentioning

confidence: 99%

Sarcopenia and Exercise “The State of the Art”

Musumeci

2017

JFMK

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“…Therefore, it is essential to investigate strategies which increase muscle quality during the aging process in addition to maintaining or increasing the lean body mass in order to prevent or delay functional impairment as an anti-aging therapy [47].…”

Section: Body Composition As a Health Biomarker In Agingmentioning

confidence: 99%

Fitness Assessment as an Anti-Aging Marker: A Narrative Review

Amaro‐Gahete¹,

De-la-O²,

Jurado‐Fasoli³

et al. 2017

J Gerontol Geriatr Res

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Aging is a natural, physiological, and inevitable process, but it can be also influenced. Although aging is not a disease, it has several characteristics that could indicate so, such as a functional decline at different levels, which may determine clinical manifestations, and it is associated with several disease processes. Consequently, it is essential to create and adopt strategies to delay the aging process. Nowadays, any strategy adopted without including physical exercise seems inconceivable. Recent studies published in relation to this population have shown that the maintenance of acceptable levels of physical fitness is associated with the prevention of many of premature aging consequences, good rates of health, and quality of life of the person. cardiorespiratory fitness and muscular strength (as physical fitness components) are excellent life expectancy and quality of life predictors. Therefore, reaching a good fitness level is the most powerful clinical method to prevent and delay the aging process. Not only their years to live increase, but also their quality, with health and without diseases or mobility dependence.

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“…Aging is a process characterized by musculoskeletal changes probably induced by reduced quality, quantity and muscle function (1,2) . These modifications tend to reflect negatively on the ability of the elderly to live independently and to perform movements that satisfy basic daily needs, a concept assumed by the authors as functional capacity.…”

Section: Introductionmentioning

confidence: 99%

Effects of power training on quality of life and postural stability in elderly

Tolentino¹,

Soares²,

Venâncio³

et al. 2020

mtprehabjournal

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Introduction:The muscular strength exercises can be an effective intervention to prevent falls and to favor the functional capacity (FC) in the elderly. However, few studies have reported the benefits of power training (PT) and the subjective perception of the elderly on these activities. Objective: to evaluate the repercussions of a power training protocol on functional capacity and subjective health parameters in the elderly. Method: It was a prospective study involving 48 elderly people. Two groups were composed: a power training group (PG) with 22 participants with a mean age of 68.14 (5.46) years and the control group (CG) was composed of 32 elderly individuals aged 68.03 (4.83) years. Health-related quality of life was measured from the Medical Outcomes Study 36 -Item Short-Form Health Survey (SF-36). The FC was measured by the Berg Balance and Time Up and Go tests. The PT was performed 2x/week, with duration of 50 min/session, for 14 weeks (first two weeks of adaptation; first six weeks 3X/10-15 repetitions of 40-50% of the Subjective Perceived Exertion (SPE) / 6 following weeks 3X/6-10 repetitions of 60-70% of the SPE). The CG performed rhythm activities with the same frequency and weekly duration. Result: It was observed favorable results in FC after 14 weeks of power training. There was also a positive evaluation of most sf-36 domains, with emphasis on physical and emotional aspects. However, the perception of the elderly in relation to the pain domain presented negative results. Conclusion: The PT positively influenced the FC, the physical and the emotional aspects of the elderly; negatively affected the pain and maintained the low risk of fall after 12 weeks of intervention, without presenting intercurrences during the intervention.

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Skeletal muscle aging: influence of oxidative stress and physical exercise

Cited by 201 publications

References 144 publications

Sarcopenia and Exercise “The State of the Art”

Sarcopenia and Exercise “The State of the Art”

Fitness Assessment as an Anti-Aging Marker: A Narrative Review

Effects of power training on quality of life and postural stability in elderly

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