Overweight of Korean male workers and genetic polymorphism of insulin receptor substrate 1 (IRS1) gene

Kim, Ki Woong; Heo, Kyung-Hwa; Won, Yong Lim; Ko, Kyung Sun; Kim, Tae Kyun; Lee, Mi Young; Park, Jungsun; Paik, Sang‐Gi

doi:10.1080/19768354.2009.9647203

Cited by 3 publications

(3 citation statements)

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“…In a study in Japanese workers, Yamada et al . (2007) reported that genetic polymorphisms of insulin receptor substrate 1 (IRS1) and β3-adrenergic receptor (β3-AR) were associated with CVD risk factors such as obesity, insulin resistance and type 2 diabetes development; Kim et al . (2009) also reported that obesity was sensitive to IRS1 genetic polymorphism in Korean workers.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Hazardous Chemical Exposure on Cardiovascular Disease in Chemical Products Manufacturing Workers

Kim¹,

Won²,

Ko³

et al. 2012

Toxicological Research

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The purpose of this study was to understand the mechanism of cardiovascular disease (CVD) caused by exposure to hazardous chemicals. We investigated changes in the symptoms of metabolic syndrome, which is strongly related to CVD, and in levels of other CVD risk factors, with a special emphasis on the roles of catecholamines and oxidative stress. The results revealed that neither body mass index (BMI) nor waist and hip circumferences were associated with exposure to hazardous chemicals. Among metabolic syndrome criteria, only HDL-cholesterol level increased on exposure to hazardous chemicals. Levels of epinephrine (EP) and norepinephrine (NEP) were not influenced by exposure to hazardous chemicals; however, the total antioxidative capacity (TAC) reduced because of increased oxidative stress. Both hazardous chemical exposure level and metabolite excretion were related to EP, NEP, and the oxidative stress index (OSI). Logistic regression analysis with these factors as independent variables and metabolic syndrome criteria as dependent variables revealed that EP was associated with blood pressure, and NEP with metabolic syndrome in the chemicalexposed group. In conclusion, the results suggest that reactive oxygen species generated and oxidative stress due to exposure to hazardous chemicals act as mediators and cause changes in the physiological levels of EP and NEP to increase blood pressure. This ultimately leads to the development of CVD through increase in cholesterol, triglyceride, and blood glucose levels by lipid peroxidation.

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Section: Introductionmentioning

confidence: 99%

The Effects of Hazardous Chemical Exposure on Cardiovascular Disease in Chemical Products Manufacturing Workers

Kim¹,

Won²,

Ko³

et al. 2012

Toxicological Research

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“…Regardless of smoking habits, while AdipoN level was higher in the non-obese group, BDNF and Lep levels were significantly higher in the obese group ( Table 4) . Although there is a genetic influence (35) , the results allude to an imbalance in food consumption and energy expenditure due to a change in AdipoN, BDNF, and LeP concentration. CVD is closely related to obesity and MetS, and seems to reasonably correlate with neuropeptides (36 , 37) .…”

Section: Discussionmentioning

confidence: 99%

Smoking Habits and Neuropeptides: Adiponectin, Brain-derived Neurotrophic Factor, and Leptin Levels

Kim¹,

Won²,

Ko³

et al. 2014

Toxicological Research

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This study aimed to identify changes in the level of neuropeptides among current smokers, former smokers, and individuals who had never smoked, and how smoking habits affect obesity and metabolic syndrome (MetS). Neuropeptide levels, anthropometric parameters, and metabolic syndrome diagnostic indices were determined among male workers; 117 of these had never smoked, whereas 58 and 198 were former and current smokers, respectively. The total sample comprised 373 male workers. The results obtained from anthropometric measurements showed that current smokers attained significantly lower body weight, body mass index, waist circumference, and abdominal fat thickness values than former smokers and those who had never smoked. Current smokers’ eating habits proved worse than those of non-smokers and individuals who had never smoked. The level of brain-derived neurotrophic factor (BDNF) in the neuropeptides in the case of former smokers was 23.6 ± 9.2 pg/ml, higher than that of current smokers (20.4 ± 6.1) and individuals who had never smoked (22.4 ± 5.8) (F = 6.520, p = 0.002). The level of adiponectin among former smokers was somewhat lower than that of current smokers, whereas leptin levels were higher among former smokers than current smokers; these results were not statistically significant. A relationship was found between adiponectin and triglyceride among non-smokers (odds ratio = 0.660, β value = −0.416, p < 0.01) and smokers (odds ratio = 0.827, β value = −0.190, p < 0.05). Further, waist circumference among non-smokers (odds ratio = 1.622, β value = 0.483, p < 0.001) and smokers (odds ratio = 1.895, β value = 0.639, p < 0.001) was associated with leptin. It was concluded that cigarette smoking leads to an imbalance of energy expenditure and appetite by changing the concentration of neuropeptides such as adiponectin, BDNF, leptin, and hsCRP, and influences food intake, body weight, the body mass index, blood pressure, and abdominal fat, which are risk factors for MetS and cardiovascular disease.

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“…Park et al(2013) (Hajat & Shather, 2012;Beltran-Sanche et al, 2013;Gualla-Castillon et al, 2014 (Woods & Seeley, 2005). 이외에도 체내 에너지 불균형의 원인은 유전적 요인 (Masuo et al, 2005;Kim et al, 2009)과 환경적 요인 (Tonstad & Svendsen, 2005;Heo et al, 2009)이 복합적인 작용을 통하여 발생되는 것으로 보고되었다 (Anubhuti, 2006 (Koh et al, 1997). (Oliver, 2007).…”

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Association Between Occupational Standing Time and Metabolic Syndrome in Korean Male Workers

Kim¹

2014

Journal of Korean Society of Occupational and Environmental Hyg

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Purpose: In this study, we sought to understand the risk factor for chronic disease of workers by studying the association between occupational standing time and metabolic syndrome(MetS) in full-time 300 male workers. Materials: Data on age, life habit, work related information of the subjects were surveyed using self-reported questionnaire and interview. MetS was identified based on the report of Alberti et al.(2009). As for the data analysis, SPSS 19.0 was used to conduct the descriptive statistic, ANOVA, Pearson correlation coefficient and multiple logistic regression analysis. Results: Daily working hour affects on the lifting heavy objects, running and strenuous exercise(r=-0.137, p<0.01), and total physical function decreased with the increase in age(r=-0.145, p<0.01). Also, obese was significantly associated with genuflection and bend over(r=-0.110, p<0.05). On multiple logistic regression analysis for the diagnostic indices of MetS, occupational standing time were significantly associated with waist circumference(odds ratio=0.885, β value=-0.122, 95% CI=0.797-0.983, p<0.05) and triglyceride (odds ratio=0.873, β value=-0.136, 95% CI=0.800-0.953, p<0.01). Conclusions: These results suggest that the working posture may be important risk factor in pathogenesis and growing of MetS and cardiovascular disease.

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Overweight of Korean male workers and genetic polymorphism of insulin receptor substrate 1 (IRS1) gene

Cited by 3 publications

References 28 publications

The Effects of Hazardous Chemical Exposure on Cardiovascular Disease in Chemical Products Manufacturing Workers

The Effects of Hazardous Chemical Exposure on Cardiovascular Disease in Chemical Products Manufacturing Workers

Smoking Habits and Neuropeptides: Adiponectin, Brain-derived Neurotrophic Factor, and Leptin Levels

Association Between Occupational Standing Time and Metabolic Syndrome in Korean Male Workers

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