Overview of potential procedural and participant- related confounds for neuroimaging of the resting state

Duncan, Niall W.; Northoff, Georg

doi:10.1503/jpn.120059

Cited by 73 publications

(73 citation statements)

References 143 publications

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“…Nonsmokers (no more than 10 cigarettes consumed during their whole life) were studied to avoid confounding effects of withdrawal symptoms [20]. We recruited only male subjects to minimize gender-related bias [23] and possible hormonal interaction with nicotine [24]. All subjects gave written informed consent.…”

Section: Methodsmentioning

confidence: 99%

EEG Source Reconstruction in Male Nonsmokers after Nicotine Administration during the Resting State

Ranzi

Thiel²,

Herrmann³

2016

Neuropsychobiology

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Modern psychopharmacological research in humans focuses on how specific psychoactive molecules modulate oscillatory brain activity. We present state-of-the-art EEG methods applied in a resting-state drug study. Thirty healthy male nonsmokers were randomly allocated either to a nicotine group (14 subjects, 7 mg transdermal nicotine) or a placebo group (16 subjects). EEG activity was recorded in eyes-open (EO) and eyes-closed (EC) conditions before and after drug administration. A source reconstruction (minimum norm algorithm) analysis was conducted within a frequency range of 8.5-18.4 Hz subdivided into three different frequency bands. During EO, nicotine reduced the power of oscillatory activity in the 12.5- to 18.4-Hz frequency band in the left middle frontal gyrus. In contrast, in the EC condition, nicotine reduced the power in the 8.5- to 10.4-Hz frequency band in the superior frontal gyri and in the 10.5- to 12.4-Hz and 12.5- to 18.4-Hz frequency bands in the supplementary motor areas. In summary, nicotine reduced the power of the 12.5- to 18.4-Hz band in the left middle frontal gyrus during EO, and it reduced power from 8.5 to 18.4 Hz in a brain area spanning from the superior frontal gyri to the supplementary motor areas during EC. In conclusion, the results suggest that nicotine counteracts the phenomenon of anteriorization of α activity, hence potentially increasing the level of vigilance.

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Section: Methodsmentioning

confidence: 99%

EEG Source Reconstruction in Male Nonsmokers after Nicotine Administration during the Resting State

Ranzi

Thiel²,

Herrmann³

2016

Neuropsychobiology

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“…Thus, functional connectivity may be observed even between regions that are not functionally interacting with each other due to effects of the experimental setup. A similar consideration also holds for structured noise or confounds, such as motion or physiological effects (Birn, 2012;Duncan & Northoff, 2013). If their influence is not removed from the data or accommodated in the analysis, spurious correlations will arise.…”

Section: Functional Connectivity: Definition and Conceptual Implicationsmentioning

confidence: 99%

Functional Connectivity

Eickhoff¹,

Müller²

2015

Brain Mapping

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“…All subjects were Caucasian and students at the University of Oldenburg. We decided to use only male subjects in order to minimize gender-related confounds [21] and possible hormonal interaction with nicotine [22]. All subjects gave their written informed consent.…”

Section: Methodsmentioning

confidence: 99%

Encephalography Connectivity on Sources in Male Nonsmokers after Nicotine Administration during the Resting State

Ranzi

Freund²,

Thiel³

et al. 2016

Neuropsychobiology

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We present an encephalography (EEG) connectivity study where 30 healthy male nonsmokers were randomly allocated either to a nicotine group (14 subjects, 7 mg of transdermal nicotine) or to a placebo group. EEG activity was recorded in an eyes-open (EO) and eyes-closed (EC) condition before and after drug administration. This is a reanalysis of a previous dataset. Through a source reconstruction procedure, we extracted 13 time series representing 13 sources belonging to a resting-state network. Here, we conducted connectivity analysis (renormalized partial directed coherence; rPDC) on sources, focusing on the frequency range of 8.5-18.4 Hz, subdivided into 3 frequency bands (α₁, α₂, and β₁) with the hypothesis that an increase in vigilance would modulate connectivity. Furthermore, a phase-amplitude coupling (mean resultant vector length; VL) analysis, was performed investigating whether an increase of vigilance would modulate phase-amplitude coupling. In the VL analysis we estimated the coupling of the phases of 3 low frequencies (α₁, α₂, and β₁), respectively, with the amplitude of high-frequency oscillations (30-40 Hz, low γ). With rPDC we found that during the EC condition, nicotine decreased feedback connectivity (from the precentral gyrus to precuneus, angular gyrus, cuneus and superior occipital gyrus) at 10.5-12.4 Hz. The VL analysis showed nicotine-induced increases in coupling at 10.5-18.4 Hz in the precuneus, cuneus and superior occipital gyrus during the EC condition. During the EO condition, no significant results were found in connectivity or phase-amplitude coupling measures at any frequency range. In conclusion, the results suggest that nicotine potentially increases the level of vigilance in the EC condition.

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Overview of potential procedural and participant- related confounds for neuroimaging of the resting state

Cited by 73 publications

References 143 publications

EEG Source Reconstruction in Male Nonsmokers after Nicotine Administration during the Resting State

EEG Source Reconstruction in Male Nonsmokers after Nicotine Administration during the Resting State

Functional Connectivity

Encephalography Connectivity on Sources in Male Nonsmokers after Nicotine Administration during the Resting State

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