Functional Connectivity

Eickhoff, Simon B.; Müller, Veronika I.

doi:10.1016/b978-0-12-397025-1.00212-8

Cited by 50 publications

(28 citation statements)

References 35 publications

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“…Thus, the functional coupling between face-processing areas and the cerebellum may represent the processes of integration of the emotional meaning of facial expressions. However, we must keep in mind that functional connectivity does not necessarily imply a causal relationship between two areas (Eickhoff & Müller, 2015). Therefore, there are other possible interpretations in which the cerebellum receives the input from FFAs and OFA or in which there exists exchange of information between these areas.…”

Section: Discussionmentioning

confidence: 99%

The relationship between early and recent life stress and emotional expression processing: A functional connectivity study

Sokołowski

Folkierska-Żukowska

Jednoróg

et al. 2020

Cogn Affect Behav Neurosci

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The aim of this study was to characterize neural activation during the processing of negative facial expressions in a non-clinical group of individuals characterized by two factors: the levels of stress experienced in early life and in adulthood. Two models of stress consequences were investigated: the match/mismatch and cumulative stress models. The match/mismatch model assumes that early adversities may promote optimal coping with similar events in the future through fostering the development of coping strategies. The cumulative stress model assumes that effects of stress are additive, regardless of the timing of the stressors. Previous studies suggested that stress can have both cumulative and match/mismatch effects on brain structure and functioning and, consequently, we hypothesized that effects on brain circuitry would be found for both models. We anticipated effects on the neural circuitry of structures engaged in face perception and emotional processing. Hence, the amygdala, fusiform face area, occipital face area, and posterior superior temporal sulcus were selected as seeds for seed-based functional connectivity analyses. The interaction between early and recent stress was related to alterations during the processing of emotional expressions mainly in to the cerebellum, middle temporal gyrus, and supramarginal gyrus. For cumulative stress levels, such alterations were observed in functional connectivity to the middle temporal gyrus, lateral occipital cortex, precuneus, precentral and postcentral gyri, anterior and posterior cingulate gyri, and Heschl's gyrus. This study adds to the growing body of literature suggesting that both the cumulative and the match/mismatch hypotheses are useful in explaining the effects of stress.

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Section: Discussionmentioning

confidence: 99%

The relationship between early and recent life stress and emotional expression processing: A functional connectivity study

Sokołowski

Folkierska-Żukowska

Jednoróg

et al. 2020

Cogn Affect Behav Neurosci

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“…Recently, the communication and interaction between them and anatomically separated neural regions came into focus of affective and stress-related neuroimaging research. Temporally dependent activation patterns in spontaneous activity of two different areas might indicate an exchange of information between functionally linked neural regions (Eickhoff and Müller, 2015; Friston et al, 1993). The amygdala interacts with multiple brain regions involved in the regulation of social, affective and stress-related information (Robinson et al, 2011; Roy et al, 2010; Stein et al, 2007), including lateral and medial frontal areas, posterior cingulate cortex, hippocampus, hypothalamus and brainstem regions.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the functional connectivity of the amygdalae in association with cortisol

et al. 2016

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Human amygdalae are involved in various behavioral functions such as affective and stress processing. For these behavioral functions, as well as for psychophysiological arousal including cortisol release, sex differences are reported. Here, we assessed cortisol levels and resting-state functional connectivity (rsFC) of left and right amygdalae in 81 healthy participants (42 women) to investigate potential modulation of amygdala rsFC by sex and cortisol concentration. Our analyses revealed that rsFC of the left amygdala significantly differed between women and men: Women showed stronger rsFC than men between the left amygdala and left middle temporal gyrus, inferior frontal gyrus, postcentral gyrus and hippocampus, regions involved in face processing, inner-speech, fear and pain processing. No stronger connections were detected for men and no sex difference emerged for right amygdala rsFC. Also, an interaction of sex and cortisol appeared: In women, cortisol was negatively associated with rsFC of the amygdalae with striatal regions, mid-orbital frontal gyrus, anterior cingulate gyrus, middle and superior frontal gyri, supplementary motor area and the parietal-occipital sulcus. Contrarily in men, positive associations of cortisol with rsFC of the left amygdala and these structures were observed. Functional decoding analyses revealed an association of the amygdalae and these regions with emotion, reward and memory processing, as well as action execution. Our results suggest that functional connectivity of the amygdalae as well as the regulatory effect of cortisol on brain networks differs between women and men. These sex-differences and the mediating and sex-dependent effect of cortisol on brain communication systems should be taken into account in affective and stress-related neuroimaging research. Thus, more studies including both sexes are required.

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“…ICA is a model-free analysis technique that allows one to characterize the spatio-temporal structure of the data. ICA identifies mutually independent sets of regions (component) exhibiting high within-component functional connectivity36.…”

Section: Methodsmentioning

confidence: 99%

Neuroanatomical correlates of forgiving unintentional harms

Patil

Calò

Fornasier

et al. 2017

Sci Rep

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Mature moral judgments rely on the consideration of a perpetrator’s mental state as well as harmfulness of the outcomes produced. Prior work has focused primarily on the functional correlates of how intent information is neurally represented for moral judgments, but few studies have investigated whether individual differences in neuroanatomy can also explain variation in moral judgments. In the current study, we conducted voxel-based morphometry analyses to address this question. We found that local grey matter volume in the left anterior superior temporal sulcus, a region in the functionally defined theory of mind or mentalizing network, was associated with the degree to which participants relied on information about innocent intentions to forgive accidental harms. Our findings provide further support for the key role of mentalizing in the forgiveness of accidental harms and contribute preliminary evidence for the neuroanatomical basis of individual differences in moral judgments.

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Functional Connectivity

Cited by 50 publications

References 35 publications

The relationship between early and recent life stress and emotional expression processing: A functional connectivity study

The relationship between early and recent life stress and emotional expression processing: A functional connectivity study

Sex differences in the functional connectivity of the amygdalae in association with cortisol

Neuroanatomical correlates of forgiving unintentional harms

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