Overview of Innovative Technologies in Liquid‐Liquid Extraction Regarding Flexibility

Polyakova, Maria; Diekmann, Anna‐Lena; Grünewald, Marcus

doi:10.1002/cite.202000081

Cited by 10 publications

(12 citation statements)

References 89 publications

(135 reference statements)

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“…Almost all analytical measurements require some form of sample preparation which may include simple filtration of the sample, extraction of an analyte from quite complex sample matrices, or concentration of analyte(s) for detection [1, 2]. Liquid‐liquid extraction [3–5] and SPE [6, 7] are well‐known methods used to enrich sample concentrations between 10 and 1000 times [8].…”

Section: Introductionmentioning

confidence: 99%

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A novel three‐dimensional printed device with conductive elements for electromembrane extraction combined with high‐performance liquid chromatography and ultraviolet detector

Dolatabadi

Mohammadi

Walker

2022

J of Separation Science

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This study is focused on proposing a new design and setup for electromembrane extraction. A new cap was designed and conductive vials of different shapes were fabricated using three‐dimensional printing. The new cap holds three fibers to enhance electromembrane extraction recovery. Conductive vials can simultaneously perform as electrodes therefore, there is no need to include an electrode in sample solutions. Phenobarbital and phenytoin were used as model compounds to assess the setup performance. Under optimal conditions, these analytes were extracted from the sample solution at pH = 9 to the acceptor solution at pH = 13 with a voltage of 40 V for 20 min, while 1‐octanol was employed as the supported‐liquid‐membrane. The influence of conductive vials geometry on the recovery was examined and the effects of different shapes were studied by performing numerical simulation to establish electric potential distribution. Of the vials tested with circular, triangular, and floral‐like cross‐sections the latter exhibited the best voltage distribution. The circular vial had the highest recovery attributed to its better hydrodynamic shape, which allows rapid fluid sample transport and therefore enhanced system recovery. The extraction recovery and relative standard deviation of the circular vial with three fibers were 33.0 and 7.6 for phenobarbital and 42.2 and 10.4 for phenytoin.

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Section: Introductionmentioning

confidence: 99%

“…complex sample matrices, or concentration of analyte(s) for detection [1,2]. Liquid-liquid extraction [3][4][5] and SPE [6,7] are well-known methods used to enrich sample concentrations between 10 and 1000 times [8].…”

Section: Introductionmentioning

confidence: 99%

A novel three‐dimensional printed device with conductive elements for electromembrane extraction combined with high‐performance liquid chromatography and ultraviolet detector

Dolatabadi

Mohammadi

Walker

2022

J of Separation Science

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“…69,98 Flexibilities in the purification of bio-based products have been investigated for sedimentation, thermal drying, membrane separation, distillation, cryogenic separation, and absorption processes. A comprehensive review of flexibility options in liquid-liquid extraction was conducted by Polyakova et al, 99 The possible FOL of investigated process steps that are found in biofuel production and can be operated flexibly are summarized in Figure 6.…”

Section: Refining Processesmentioning

confidence: 99%

Options for demand side management in biofuel production: A systematic review

Röder

Gröngröft

Grünewald

et al. 2022

Intl J of Energy Research

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Summary To minimize the emissions from the production of biofuels, one aim is to reduce or completely replace the amount of fossil fuels used for internal process energy. A conceivable solution is the use of volatile renewable energy sources such as solar and wind. The fluctuation of these energy sources in their production inevitably leads to a transformation to flexible power consumption, commonly referred to as demand side management (DSM). In current research, a wide range of processes has been identified to be suitable for DSM application. Although biorefineries have not yet been tested for DSM application, it is noteworthy that many of the DSM suitable processes are employed in biofuel plants. Thus, this contribution offers a comprehensive overview of DSM options drawn from literature with a special focus on process steps, which have been analysed for operational and capacity flexibility and which are found in or are transferable to biorefinery systems. By identifying process steps in biofuel production that can be operated flexibly, this extensive literature study helps to find technical restrictions limiting the overall process flexibility. The scope of this contribution is to create an overview of which processes in biofuel production can be considered for DSM use.

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“…Liquid–liquid extraction processes are widely used in different fields of fine chemistry, pharmaceutical production, and so forth. The stirred solvent extraction column operated in the countercurrent mode plays an important role in today’s chemical industry …”

Section: Introductionmentioning

confidence: 99%

Implementation of a Control Strategy for Hydrodynamics of a Stirred Liquid–Liquid Extraction Column Based on Convolutional Neural Networks

et al. 2022

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Online process supervision is enabled by smart sensor development, hence attracting increasing attention in pharmaceutical and chemical process engineering. Additional sensor data enable more precise process control as additional process parameters can be monitored. They are easy to integrate into modular plants, and their provided additional process parameters enable a more flexible operation of the apparatus due to the quick and more sensitive reaction to changing circumstances. An artificial intelligence-based optical sensor for the investigation of different operating states and droplet sizes within a liquid−liquid stirred DN32 extraction column in counter current flow is developed and presented in this work. Two operating states, the flooding state and the column's regular operating state, are differentiated as observable states. Additionally, the diameter of the rising liquid droplets of the disperse phase is categorized into different diameter classes. A control strategy for the extraction column is derived based on the results of the convolutional neural network-based image analysis. Thus, a robust soft sensor controlling the hydrodynamics of an extraction column was developed. The developed control strategy automatically leads the extraction column into a favorable hydrodynamically stable operation state.

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Overview of Innovative Technologies in Liquid‐Liquid Extraction Regarding Flexibility

Cited by 10 publications

References 89 publications

A novel three‐dimensional printed device with conductive elements for electromembrane extraction combined with high‐performance liquid chromatography and ultraviolet detector

A novel three‐dimensional printed device with conductive elements for electromembrane extraction combined with high‐performance liquid chromatography and ultraviolet detector

Options for demand side management in biofuel production: A systematic review

Implementation of a Control Strategy for Hydrodynamics of a Stirred Liquid–Liquid Extraction Column Based on Convolutional Neural Networks

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