Overview of G Proteins (GTP-Binding Proteins) in Eukaryotes

Pandey, Girdhar K.; Sharma, Manisha; Pandey, Amita; Shanmugam, Thiruvenkadam

doi:10.1007/978-3-319-11611-2_1

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…In Ayurveda, it is mentioned as Hridya (Cardiac tonic). The bark powder of Arjuna is given for the treatment of kshata (injury or wound), kshaya (emitiated condition), visha (poison), raktavikara (as a styptic), medaroga (diabetic issues), prameha (urinary disorders), vrana (ulcer/wound), etc [49] Rasa panchak of the T. arjuna [50] is shown in the table no. 3.…”

Section: Ayurvedic Viewmentioning

confidence: 99%

Terminalia arjuna: A Potential Ayurvedic Cardio Tonic

Thakur¹,

Kaurav²,

Chaudhary³

2021

Int. j. res. appl. sci. biotechnol.

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Herbal plants have been a significant source of therapeutic agents to cure human diseases. Plants are being in use for treating various kinds of diseases across the world. Terminalia arjuna is a widely used herbal plant since ancient times. The ancient indian practitioners utilized the powdered tree bark of arjuna for the treatment of "hritshool" (angina) and other cardiovascular problems. Terminalia arjuna is regionally called as arjuna which belongs to the combretaceae family. The plant is utilized as a medicine in the various indigenous system like ayurveda, siddha and unani. Arjunic acid, arjunolic acid, arjungenin, arjunone, arjunolone and luteolin, gallic acid, ellagic acid, oligomeric proanthocyanidins (opcs), phytosterols are the major phytoconstituents of Terminalia arjuna that possesses many useful biological properties like anti-microbial, anti-inflammatory, antioxidant, antifeedant, cardio protective, etc. Various clinical evidence of Terminalia arjuna and its beneficial effects on the cardiovascular system. The present review is summarizing the phytomedicinal value of Terminalia arjuna in ayurveda and the folk system of medicine.

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Section: Ayurvedic Viewmentioning

confidence: 99%

Terminalia arjuna: A Potential Ayurvedic Cardio Tonic

Thakur¹,

Kaurav²,

Chaudhary³

2021

Int. j. res. appl. sci. biotechnol.

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“…Numerous studies on the design of nanoparticle-based anti-TB drugs over the past decade report their potential to improve drug bioavailability and reduce drug dosing frequency. [14], [16]- [18] However, despite promising results, physical loading of anti-TB drugs in nanoparticles was characterized by a poor loading efficiency and a burst release. As an alternative strategy, in this work, drugpolymer conjugation has been considered to improve the absorption and bioavailability of anti-TB-type medications.…”

Section: Introductionmentioning

confidence: 99%

Pyrazinoic acid-Poly(malic acid) biodegradable nanoconjugate for efficient intracellular delivery

Carneiro

Moine

Tessier

et al. 2019

PRNANO

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Tuberculosis is an infectious disease affecting mostly lungs, that is still considered a health global problem as it causes millions of deaths worldwide. Current treatment is effective but associated with severe adverse effects due to the high doses of each anti-tuberculosis drug daily administrated by oral therapy. For the first time, a pyrazinoic acid (PA) biodegradable nanoconjugate was synthesized and developed for pulmonary administration in an attempt to reduce the administered doses by achieving a high drug payload and controlled release at the target site. The conjugate was synthesized by coupling pyrazinoic acid on carboxylic groups of poly(malic acid), which is a biodegradable and biocompatible polymer, and posteriorly self-assembled into nanoconjugates. Characterization confirmed the formation of nanometric, spherical and negatively charged pyrazinoic acid nanoconjugate (NC-PA). NC-PA was stable for 60 days at 4 and 37°C and able to deliver PA in a sustained release manner over time. On macrophages, they exhibited no cell toxicity for a wide range of concentrations (from 1 to 100 µg/mL), demonstrating the safety of NC-PA. In addition, the nanoconjugate was efficiently taken up by RAW 264.7 cells over 6 hours reaching a maximum value after 3 hours of incubation. In conclusion, innovative nanoconjugates are a promising alternative to deliver drugs directly to the lungs and contributing to improving tuberculosis therapy.

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“…At the end of the verses describing preparation of Kunapajala, it has been stated that Kunapajala is very effective and acts as plant nutrient or nourish reproductive stages of plants. [4] Many research works have been shown excellent results on vegetative plants like Chili, Mango, Coconut and Kiwi fruit after application of Kunapajala. [5] But very few works have been done to assess the efficacy of Kunapajala on medicinal plants.…”

Section: Introductionmentioning

confidence: 99%