Overexpression of matrix metalloproteinase-7 (MMP-7) correlates with tumor proliferation, and a poor prognosis in non-small cell lung cancer

Liu, Dage; Nakano, Jun; Ishikawa, S; Yokomise, Hiroyasu; Ueno, Masaki; Kadota, Kyuichi; Urushihara, Masahide; Huang, Cheng-long

doi:10.1016/j.lungcan.2007.07.005

Cited by 104 publications

(89 citation statements)

References 42 publications

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“…MMP-7 has been reported to have multiple biologic functions related to tumor behavior, such as growth, invasion, proliferation and apoptosis. In addition, a relation between MMP-7 expression and postoperative outcomes has been reported (12)(13)(14), but definitive evidence is lacking. Therefore, we studied immunohistochemically the expression of IGF-1R and MMP-7 in post-surgical patients with NSCLC.…”

Section: Discussionmentioning

confidence: 99%

“…As for histological type, IGF-1R expression was slightly, but not significantly, higher in squamous cell carcinomas. Concerning MMP-7 expression, Liu et al (12) showed that MMP-7 expression was significantly higher in squamous cell carcinomas than in adenocarcinomas. Leinonen et al (13) reported that high MMP-7 expression was related to lower T-factor and well-differentiated tumors; moreover, MMP-7 expression was higher in adenocarcinomas than in other histological subtypes.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, overall survival was significantly poorer in patients with IGF-1R-high tumors than in those with IGF-1R-low tumors, and multivariate analysis showed IGF-1R expression as an independent indicator of poor outcomes. As for MMP-7, Liu et al (12) reported that the overall survival rate was significantly lower in patients with MMP-7-positive NSCLC than in those with MMP-7-negative NSCLC. On the other hand, Leinonen et al (13) reported that MMP-7 had no prognostic value in NSCLC.…”

Section: Discussionmentioning

confidence: 99%

“…Increased expression of MMP-7 in cancer cells is associated with tumor progression and metastasis in various types of cancer (10,11). To date, few studies have examined the expression of MMP-7 in lung cancer (12)(13)(14).…”

Section: Clinical Significance Of Immunohistochemical Expression Ofmentioning

confidence: 99%

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Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer

Yamamoto

Oshima

Yoshihara

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. Insulin-like growth factor-1 receptor (IGF-1R) and matrix metalloproteinase-7 (MMP-7) have been reported to be related to tumor invasion and metastasis in various malignancies. The aim of this study was to evaluate the expression levels of IGF-1R and MMP-7 in resected non-small cell lung cancer (NSCLC) and to examine the relationship of such levels to clinical characteristics and survival. Expression was measured immunohistochemically. The percentage of stained cells was multiplied by the staining intensity. The sample was classified as high when the score was equal or higher than the median value or was otherwise considered to be low. High IGF-1R expression was associated with nodal metastasis and recurrence (P=0.034 and 0.006, respectively). High IGF-1R expression was associated with significantly poorer overall survival than low IGF-1R expression (P=0.011). MMP-7 expression did not significantly correlate with any clinicopathological factor. There was a trend toward slightly, but not significantly poorer survival in patients with MMP-7-high tumors than in those with MMP-7-low tumors (P=0.220). There was no significant correlation between IGF-1R expression and MMP-7 expression (P=0.184). Upon multivariate analysis, IGF-1R expression was independently related to the outcomes of patients with NSCLC. Overexpression of IGF-1R may be a useful predictor of lymph node metastasis, recurrence and post-surgical outcomes in patients with NSCLC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Clinical Significance Of Immunohistochemical Expression Ofmentioning

confidence: 99%

See 2 more Smart Citations

Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer

Yamamoto

Oshima

Yoshihara

et al. 2012

Experimental and Therapeutic Medicine

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show abstract

“…In lung cancer, the expression of a number of MMPs and their inhibitors is exaggerated and may be causally linked to enhanced tumour progression and metastasis [20][21][22][23]. This will be the focus of a later instalment in the series by H. MCGARRY and N. KAMINSKI.…”

mentioning

confidence: 95%

MMPs are regulatory enzymes in pathways of inflammatory disorders, tissue injury, malignancies and remodelling of the lung

Müller–Quernheim¹

2011

European Respiratory Journal

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Clinical Relevance of MMP and TIMP Measurements in Cancer Tissue

Bashir

Cao

Zucker

2012

Matrix Proteases in Health and Disease

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Overexpression of matrix metalloproteinase-7 (MMP-7) correlates with tumor proliferation, and a poor prognosis in non-small cell lung cancer

Cited by 104 publications

References 42 publications

Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer

Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer

MMPs are regulatory enzymes in pathways of inflammatory disorders, tissue injury, malignancies and remodelling of the lung

Clinical Relevance of MMP and TIMP Measurements in Cancer Tissue

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