MMPs are regulatory enzymes in pathways of inflammatory disorders, tissue injury, malignancies and remodelling of the lung

Müller–Quernheim, Joachim

doi:10.1183/09031936.00079311

Cited by 16 publications

(9 citation statements)

References 29 publications

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“…MMP-7 is an endopeptidase that belongs to the MMP family. In addition to its basic functions in cleaving extracellular matrix substrates, MMP-7 is also involved in the development of local and systemic inflammation [54][55][56]. Although MMP-2 and MMP-9 seem to play major roles in the degradation of the extracellular matrix that leads to muscle wasting, the pathophysiological relevance of MMP-7 in the development and progression of sarcopenia is still mostly unknown.…”

Section: Discussionmentioning

confidence: 99%

Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patient

Lee

Kim

Jung

et al. 2020

Preprint

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Background Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, the two most commonly used methods of assessing physical performance. Methods We obtained data regarding gait speed and handgrip strength from 277 hemodialysis patients and evaluated their relationships with baseline parameters, mental health, plasma inflammatory markers, and major adverse clinical outcomes. Low physical performance was defined by the recommendations suggested by the Asian Working Group on Sarcopenia. Results The prevalence of low gait speed and handgrip strength was 28.2% and 44.8%, respectively. Old age, low serum albumin levels, high comorbidity index score, and impaired cognitive functions were associated with low physical performance. Patients with isolated low gait speed exhibited a general trend for worse quality of life than those with isolated low handgrip strength. Gait speed and handgrip strength showed very weak correlations with different determining factors (older age, the presence of diabetes, and lower serum albumin level for low gait speed, and lower body mass index and the presence of previous cardiovascular events for low handgrip strength). Patients with low gait speed and handgrip strength had elevated levels of plasma endocan and matrix metalloproteinase-7 and the highest risks for all-cause mortality and cardiovascular events among the groups (adjusted hazard ratio of 2.72, p = 0.024). Elderly patients with low gait speed and handgrip strength were at the highest risk for poor clinical outcomes. Conclusion Gait speed and handgrip strength reflected distinctive aspects of patient characteristics and the use of both factors improved the prediction of adverse clinical outcomes in hemodialysis patients. Gait speed seems to be a better indicator of poor patient outcomes than is handgrip strength.

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Section: Discussionmentioning

confidence: 99%

Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patient

Lee

Kim

Jung

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…MMP-7 is an endopeptidase that belongs to a member of the MMP family. In addition to its basic functions in cleaving extracellular matrix substrates, MMP-7 is also involved in the development of local and systemic inflammation [47][48][49]. Although MMP-2 and MMP-9 seem to play major roles in the degradation of the extracellular matrix that leads to muscle wasting, the pathophysiological relevance of MMP-7 in the development and progression of sarcopenia is still mostly unknown.…”

Section: Discussionmentioning

confidence: 99%

Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patient

Lee

Kim

Jung

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, the two most commonly used methods to assess physical performance.Methods We obtained data regarding gait speed and handgrip strength from 277 hemodialysis patients and evaluated their relationship with baseline parameters, mental health, plasma inflammatory markers, and major adverse clinical outcomes. Low physical performance was defined by the recommendations suggested by the Asian Working Group on Sarcopenia.Results The prevalence of low gait speed and handgrip strength were 28.2% and 44.8%, respectively. Old age, low serum albumin levels, high comorbidity index, and impaired cognitive functions were associated with low physical performance. Patients with isolated low gait speed exhibited a general trend for worse quality of life than those with isolated low handgrip strength. Gait speed and handgrip strength showed very weak correlations with had different determinant factors (older age, the presence of diabetes, and lower serum albumin for low gait speed, and lower body mass index, and the presence of previous cardiovascular events for low handgrip strength). Patients with low gait speed and handgrip strength had elevated levels of plasma endocan and matrix metalloproteinase-7 and the highest risk of all-cause mortality and cardiovascular events among the groups (adjusted hazard ratio of 2.72, p = 0.024).Conclusion Gait speed and handgrip strength reflected distinctive aspects of patient characteristics and that their combination improved the prediction of adverse clinical outcomes in hemodialysis patients. Gait speed seems to be a better indicator for poor patient outcomes compared with handgrip strength.

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“…However, this is clear from the available evidence that probably no pathology can ensue or continue without the participation of this enzyme system being dysregulated. [ 7 ]…”

Section: Discussionmentioning

confidence: 99%

Role of doxycycline to resolve different types of non-malignant lung and pleural pathology: The results of a pilot observation

Bhattacharyya¹,

Dey²,

Saha³

et al. 2015

Lung India

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Background:Lung lesions may develop from tissue reactions to known or unknown stimuli and present with different morphological descriptions. The pathogenesis may be induced and maintained by different bioactive substances, of which, the upregulation matrix metalloproteinases (MMPs) play a vital role. Inhibition of the MMPs, therefore, may be a prospective mode of therapy for such lesions.Materials and Methods:A number of patients with lung lesions of different morphologies and presentations were treated empirically with long-term oral doxycycline (100 mg BID) upon exclusion of malignancy and infection in an open, single-arm, prospective, observational pilot study. The effect of the treatment was recorded on serial x-rays/computed tomography (CT) scans and the impact of treatment was measured with a visual analog scale (VAS) or a Likert-like scale. Furthermore, six independent pulmonologists’ opinion (expressed on a ‘0’ to ‘100’ scale) were pooled with regard to the significance and the expectedness of such a change.Results:Twenty-six patients (mean age 49.33 years and male: female ratio = 10:3) with different types of pulmonary parenchymal/pleural lesions were treated with long-term oral doxycycline for a mean duration of 386.88 days related to the available radiological comparison. They showed a mean improvement of 3.99 on the Likert-like scale and 78% on the VAS scale. The mean significance of the change was 83.33%, with a mean expectedness of 18% as per the pooled opinion of the pulmonologists.Inference:The significant and unexpected resolution of different tissue lesions from long-term doxycycline appears to be a novel observation. This needs proper scientific validation.

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MMPs are regulatory enzymes in pathways of inflammatory disorders, tissue injury, malignancies and remodelling of the lung

Cited by 16 publications

References 29 publications

Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patient

Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patient

Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patient

Role of doxycycline to resolve different types of non-malignant lung and pleural pathology: The results of a pilot observation

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