Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer

Yamamoto, Taketsugu; Oshima, Takashi; Yoshihara, Kazuo; Nishi, Teppei; Arai, Hiromasa; Inui, Kentaro; Kaneko, Takeshi; Nozawa, Akio; Adachi, Hiroyuki; Rino, Yasushi; Masuda, Munetaka; Imada, Toshio

doi:10.3892/etm.2012.493

Cited by 25 publications

(25 citation statements)

References 20 publications

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“…A phase II study showed that agents which target at IGF-1R exhibited a promising efficacy against advanced NSCLC [18], whereas, the prognostic value of IGF-1R is still controversial. Yamamoto et al [9] demonstrated that the overall survival (OS) in NSCLC patients with IGF-1R-high expression was significantly poorer than those in IGF-1R-low expression patients, however, Kim et al [19] revealed that the expression level of IGF-1R in NSCLC was not related to OS. To clarify the precise prognostic and clinical value of IGF-1R in NSCLC, a meta-analysis is needed.…”

Section: Introductionmentioning

confidence: 99%

“…When IGF-1 and IGF-2 bind to the extracellular subunit domain of IGF-1R, the tyrosine kinase activity of IGF-1R can be activated and the activation of IGF-1R can trigger a cascade of reactions involving signal transduction pathways such as Ras, Raf and mitogen-activated protein kinase (MAPK) [8]. It is reported that the overexpression of IGF-1R can promote tumor growth, progression, invasion and metastasis [9]. A large number of studies have revealed that IGF-1R was dysregulated in a variety of cancers including breast cancer [10, 11], liver cancer [12, 13], gastric cancer [14] and lung cancer [15, 16], suggesting a vital role of IGF-1R in cancers.…”

Section: Introductionmentioning

confidence: 99%

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The Prognostic and Clinicopathological Significance of IGF-1R in NSCLC: a Meta-Analysis

Zhao¹,

Shi²,

Wang³

et al. 2017

Cell Physiol Biochem

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Background/Aims: Accumulating studies have reported that IGF-1R (Insulin-like growth factor-1 receptor) is aberrantly expressed in NSCLC (non-small cell lung cancer), but the role of IGF-1R in NSCLC remains controversial. The present paper assessed the precise role of IGF-1R in NSCLC. Methods: We comprehensively searched PubMed, EMBASE, and Web of Science in March 2017. Combined HRs and ORs were used to evaluate the prognostic and clinicopathological significance of IGF-1R in NSCLC respectively. Results: A total of 10 eligible studies including 8 on overall survival, and 10 on clinicopathological features were identified from the databases. The results showed that high expression of IGF-1R was associated with shorter OS (overall survival) of NSCLC patients (pooled HR 1.17,95 % CI 1.00–1.36). In addition, we found that IGF-1R was related to smoking status (OR=1.82, 95 % CI=1.35-2.44) and IGF-1R tended to be highly expressed in SCC (squamous cell carcinoma) (OR=3.40 95 % CI: 1.95-5.95). Conclusions: In summary, this meta-analysis revealed that high expression of IGF-1R was associated with poor prognosis in NSCLC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Prognostic and Clinicopathological Significance of IGF-1R in NSCLC: a Meta-Analysis

Zhao¹,

Shi²,

Wang³

et al. 2017

Cell Physiol Biochem

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“…MMP7 is over-expressed in pancreatic, gastric, and colorectal cancers [32,33], and MMP levels correlate with clinical stages of malignancy, including lymph node involvement and distant metastasis [34][35][36]. Our results showing the decreased expression of several genes involved in invasion and metastasis in A549 cells treated with MGX may facilitate elucidation of the anticancer mechanisms of MGX.…”

Section: Discussionmentioning

confidence: 96%

Target genes involved in antiproliferative effect of modified ginseng extracts in lung cancer A549 cells

Kim¹,

Choi²,

Lee³

et al. 2014

ABBS

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Lung cancer is the most common cancer and the leading cause of cancer-related deaths. Panax ginseng has long been used to treat cancer and other diseases worldwide. Most of the pharmacological actions of ginseng are attributed to a variety of ginsenosides, which are often metabolized by intestinal bacteria into more effective forms. In this study, we found that the antiproliferative activity of ginseng was increased after enzymatic processing of ginseng saponin (50% inhibitory concentration, >70 mg/ml). To elucidate the mechanism by which modified ginseng extract (MGX) induced cell death in human lung cancer cells, the gene expression profiles of A549 cells regulated by MGX were assayed using Agilent PrimeView Human Gene Expression Arrays. The expression of 17 genes involved in the regulation of cell signaling, cell metabolism, transport, and cytoskeleton-regulation was up-regulated, whereas the expression of 16 genes implicated in invasion and metastasis and cellular metabolism was down-regulated in MGXtreated A549 cells. Moreover, nuclear staining with 4 0 ,6-diamidino-2-phenylindole revealed that MGX clearly caused nuclear condensation and fragmentation which are observed in apoptosis cell. These results elucidate crucial anticancer mechanisms of MGX and provide potential new targets for the assessment of anticancer activity of MGX.

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“…However, Yamamoto et al (2012) claimed that IGF1R overexpression was related to lymph node metastasis and tumor recurrence. Also, Sun et al (2012) claimed that IGF1R expression played a role in the development of resistance to cisplatin and radiotherapy in NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Lack of any Prognostic Role of Insulin-Like Growth Factor-1 Receptor in Non-Small Cell Lung Cancer

Dilli¹,

Yıldırım²,

Süren³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The purpose of this study is to determine whether the IGF1R expression has a prognostic role in non-small cell lung cancer. Materials and Methods: Forty-seven patients histopathologically diagnosed with small cell lung cancer upon bronchoscopic biopsy or resection materials were included in the study. IGF1R expression was examined via immunohistochemical methods. In samples, >10% staining were assessed as positive and ≤10% as negative. Information about demographic datas and treatments was obtained by retrospective searches of patient files. Results: IGF1R expression was determined as positive in 38 (80.9%) and as negative in 9 (19.1%) patients. There was no significant relation between IGF1R expression and histological sub-type, local invasion, lymph node and metastasis status (p=0.842, p=0.437, 0.064, 0.447, respectively). There was also no correlation with IGF1R expression and survival (p=0.141). Conclusions: There are conflicting results between IGF1R and its prognostic effects in the various studies. It has been claimed in some studies it is not related to prognosis as in our study, and in some studies it has been claimed that it is a good prognostic factor whereas in some studies it has been claimed as being a factor for worse prognosis. We think that IGF1R expression in non-small cell lung carcinoma patients deserves further analysis, because of its potential prognostic and predictive roles.

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Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer

Cited by 25 publications

References 20 publications

The Prognostic and Clinicopathological Significance of IGF-1R in NSCLC: a Meta-Analysis

The Prognostic and Clinicopathological Significance of IGF-1R in NSCLC: a Meta-Analysis

Target genes involved in antiproliferative effect of modified ginseng extracts in lung cancer A549 cells

Lack of any Prognostic Role of Insulin-Like Growth Factor-1 Receptor in Non-Small Cell Lung Cancer

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