Ovariectomy, a model of menopause in rodents, causes a premature aging of the nervous and immune systems

Baeza, Isabel; Castro, Nuria M. De; Giménez-Llort, Lydia; Fuente, Mónica De la

doi:10.1016/j.jneuroim.2009.12.008

Cited by 69 publications

(45 citation statements)

References 54 publications

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“…In the present work we have shown that ovariectomy in female mice, which mimics human ovarian loss and has been proposed as a model of premature ageing of the nervous and immune systems (Baeza et al 2010a), causes, in peritoneal leukocytes from aged mice, similar levels to males of immunosenescence and oxidative stress.…”

Section: Discussionmentioning

confidence: 58%

“…In recent years, our research group has described the negative effects of oestrogen loss on the function and the oxi-inflammatory state of leukocytes in aged female rats and mice (De la Fuente et al 2004a;Baeza et al 2009Baeza et al , 2010a. The present work performed in peritoneal leukocytes constitutes another step forward in the characterization of ovariectomy as a good model for assessing premature ageing.…”

Section: Discussionmentioning

confidence: 77%

“…Previous studies published by our research group have described that ovariectomy results in a premature ageing of functions in rat leukocytes from spleen and axillary nodes (De la Fuente et al 2004a;Baeza et al 2009), as well as in a premature ageing of the nervous system assessed through sensorimotor and anxiety-like behavioural tests (Baeza et al 2010a). Moreover, ovariectomy also causes an accelerated imbalance between oxidant production and antioxidant levels in favour of the former, with resulting oxidative stress in spleen, liver, heart and kidney cells .…”

Section: Introductionmentioning

confidence: 89%

“…For this reason, female mice were submitted to ovariectomy or sham-operated (ovaries were manipulated but not excised) at 13 months of age according to the method previously described in Baeza et al (2010a). After surgery, mice were housed individually for some hours to allow recovery and then re-grouped in their home cages.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, ovariectomy also causes an accelerated imbalance between oxidant production and antioxidant levels in favour of the former, with resulting oxidative stress in spleen, liver, heart and kidney cells . In this context, and considering the role of oxidation and inflammation in the ageing process, we have suggested ovariectomy as a model of premature ageing (De la Fuente and Miquel 2009;Baeza et al 2010a). In addition, males in mammals generate more oxidant compounds than females, which contribute to explain why females live longer than males (Borras et al 2007).…”

Section: Introductionmentioning

confidence: 99%

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Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female mice similar to that in aged males

et al. 2011

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Immunosenescence involves age-associated restructuring changes of innate and adaptative immune functions. We have suggested that these changes of the immune system participate in the rate of ageing through modulating oxi-inflamm-ageing. Thus, age-related changes in the immune system can be biological age markers and predictors of longevity. Gender differences in oxidation status and immune functions have been observed in rats, with males showing higher oxidation and immunosenescence than females of the same age. Oestrogens are sex hormones that actively participate in modulating the mammalian immune function and, therefore, the age-related impairment of the immune response is drastically accelerated in females during the menopausal transition. Ovariectomy in rodents constitutes a good model for mimicking human oestrogen loss and thus the menopausal situation. Recently, we have shown the deleterious effects of oestrogen loss on several functions of leukocytes from immune organs in rats and mice. In addition, ovariectomised rats show similar levels in these immune functions to those in males. The present work studied several functions as well as inflammatory and oxidative stress parameters in mouse peritoneal macrophages and lymphocytes from old sham and ovariectomised females, as well as in males of the same age. In general, the results show that females, which have a higher immune response and a lower oxidation and inflammation than males, appear similar to males in the parameters studied when they have lost oestrogens by ovariectomy. Thus, these data support the positive role of oestrogens in the immune function through the ageing process.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female mice similar to that in aged males

et al. 2011

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Maca extracts and estrogen replacement therapy in ovariectomized rats exposed at high altitude

Ybañez-Julca

Asunción-Alvarez

Palacios

et al. 2020

Reprod Medicine & Biology

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Around the world, thousands of women use the Hormone Replacement Therapy (HRT) to relieve menopausal symptoms such as hot flashes, genitourinary changes, sexual dysfunction, mood disorders, bone loss, and metabolic changes. 1 However, the use of HRT in chronic non-communicable diseases remains controversial. 2 That means, HRT does not always ameliorate these symptoms in menopausal women because the pathophysiological basis are complex and the root of disease is not only due to hypoestrogenemia. 3 Clinical evidence for the use of HRT is generally related to people living at sea level, but not in the highlands. Under chronic hypoxia, reproductive age females show lower serum levels of estradiol, progesterone, and prolactin than those living at sea level. 4 These decreasing female sex hormones are usually associated with late menarche and early menopause. 5 Research is often focused on the

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Stress-related Behavioural Responses, Immunity and Ageing in Animal Models

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2012

Immunosenescence

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Ovariectomy, a model of menopause in rodents, causes a premature aging of the nervous and immune systems

Cited by 69 publications

References 54 publications

Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female mice similar to that in aged males

Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female mice similar to that in aged males

Maca extracts and estrogen replacement therapy in ovariectomized rats exposed at high altitude

Stress-related Behavioural Responses, Immunity and Ageing in Animal Models

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