Ovarian follicular development and oocyte quality in anestrous ewes treated with melatonin, a controlled internal drug release (CIDR) device and follicle stimulating hormone

Luther, J. S.; Redmer, Dale A.; Reynolds, Lawrence P.; Choi, Jong Tae; Pant, Disha; Navanukraw, Chainarong; Arnold, Daniel; Scheaffer, A N; Borowicz, P. P.; Kirsch, James D; Weigl, R.M.; Kraft, Kim C.; Grazul-Bilska, Anna T.

doi:10.1016/j.theriogenology.2004.08.015

Cited by 14 publications

(13 citation statements)

References 31 publications

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“…However, the treatment with melatonin in anoestrus did not improve fertilization rate in superovulated ewes when compared with controls (McEvoy et al, 1998;Forcada et al, 2006). Likewise, Stenbak et al (2001) reported a higher in vitro fertilization (IVF) of oocytes recovered from superovulated ewes in the breeding season than during the anoestrus, whereas no differences in fertilization rate were elucidated after IVF of oocytes recovered from superovulated ewes treated or not with melatonin in anoestrus (Luther et al, 2005).…”

Section: Fertilization Ratementioning

confidence: 86%

“…Moreover, Luther et al (2005) reported that melatonin did not improve both parameters in implanted ewes when compared with controls during the seasonal anestrous period. Previous results from our laboratory show that the addition of melatonin to the IVM medium does not improve maturation rate in oocytes from sheep ovaries recovered either in anoestrus or in the breeding season (Casao et al, unpublished results).…”

Section: Effect Of Melatonin On the Ovine Ovarymentioning

confidence: 97%

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Effect of exogenous melatonin on the ovary, the embryo and the establishment of pregnancy in sheep

Abecia¹,

Forcada²,

Casao³

et al. 2008

Animal

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Administration of melatonin to advance the breeding season in sheep has been widely used, since this hormone conveys the photoperiodic signal to the reproductive neuroendocrine axis. An increased lambing percentage has been reported following such treatment during anoestrus, which could be mediated through a higher rate of embryonic survival, either by an improvement in luteal function or by a reduction in the antiluteolytic mechanisms. The aim of this article is to review the body of knowledge on the effect of melatonin on the ovine ovary, the embryo and the establishment of pregnancy. Some studies using synchronized ewes have found that melatonin treatments during anoestrus do not improve ovulation rate by modifying the timing of follicle emergence, but increasing the number of ovulatory follicles by decreasing the atresia of medium and large follicles. On the other hand, the addition of melatonin to the in vitro maturation medium does not improve oocyte maturation rate in oocytes from sheep ovaries recovered either in anoestrus or in the breeding season. However, a luteotrophic effect of melatonin at either short or medium term has been reported. We have recently observed that melatonin implants tend to improve the survival of embryos collected from ewes after superovulation in anoestrus. More specifically, melatonin induced a significant reduction of the number and rate of non-viable (degenerate and retarded) embryos. Preliminary data from our laboratory suggest that the uterine sensitivity to progesterone -in terms of progesterone receptor expression -of superovulated ewes could be reduced by melatonin treatment. It can be concluded that the success of exogenous melatonin as a means to improve lamb production of sheep is due, at least in part, to an improvement of luteal support and embryonic survival.

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Section: Fertilization Ratementioning

confidence: 86%

Section: Effect Of Melatonin On the Ovine Ovarymentioning

confidence: 97%

Effect of exogenous melatonin on the ovary, the embryo and the establishment of pregnancy in sheep

Abecia¹,

Forcada²,

Casao³

et al. 2008

Animal

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“…In one study, after IVF of the oocytes recovered from superovulated ewes in the nonreproductive season, melatonin-treated and untreated ewes did not differ significantly in their fertilization rates (Luther et al, 2005). In another study, developmental competence of oocytes collected from ewes during the anoestrous was significantly improved by supplemental exogenous melatonin (Valasi et al, 2006).…”

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confidence: 99%

The effects of melatonin on in vitro oocyte competence and embryo development in sheep

Casao

Abecia

Pérez

et al. 2010

Span. j. agric. res.

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The aim of this study was to assess the effects of melatonin on the in vitro maturation and fertilization of sheep oocytes, and on the in vitro culture of the embryos. Oocytes from sheep ovaries collected at the slaughterhouse were divided into four groups, two of which were treated with either 10E5 M (M5) or 10E6 M (M6) melatonin, while the other two groups served as untreated controls (C5 and C6). After in vitro fertilization with fresh ram semen, the embryos produced in each group were divided into two sets, one cultured with melatonin (M5M, C5M, M6M and C6M), and the other without melatonin (M5C, C5C, M6C, and C6C). A melatonin concentration of 10E6 M increased maturation rate (82.5% vs. 73.7% for M6 and C6, respectively; P < 0.05) and tended to improve cleavage rate 36 hours after in vitro fertilization (79.4% vs. 72.6% for M6 and C6, respectively, P = 0.08). A higher melatonin concentration (10E5 M) did not have significant effects on those parameters. Blastocyst rates on day 8 did not differ significantly among groups.

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“…In this study, oocytes collected from melatonin-treated ewes showed better fertilisation rate compared with the control ones. Luther et al (2005) did not observe any effect of melatonin treatment on subsequent in vitro oocyte maturation or fertilisation. This could be related to the superovulatory gonadotrophin treatment used in that study, which might have masked the effects of melatonin on follicular development and oocyte quality (McEvoy et al, 1998).…”

mentioning

confidence: 58%

“…Data on the effects of melatonin treatment on follicular development (Haresign, 1992;Luther et al, 2005) and in vivo embryo production during anoestrus (McEvoy et al, 1998;Forcada et al, 2006) appear rather conflicting, probably due to different hormonal treatments that may mask the melatonin effect. It has been shown that melatonin affects in vitro development and fertilisation of murine oocytes (Ishizuka et al, 2000) and advances maturation, fertilisation and cleavage of bovine oocytes when selectively added to in vitro embryo production (IVP) media (personal data).…”

mentioning

confidence: 99%

Effects of melatonin treatment on follicular development and oocyte quality in Chios ewes — Short communication

Tsiligianni

Valasi

Cseh

et al. 2009

Acta Veterinaria Hungarica

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Follicular development and oocyte quality were assessed by laparoscopic observation and in vitro fertilisation, respectively, in melatonin-treated (Group M) and control (Group C) anoestrous Chios ewes (n = 10 in each group). Fourteen days after melatonin insertion, all ewes had laparoscopic evaluation of the follicular population followed by oocyte pick-up (OPU); on day 22 intravaginal progestagen sponges were inserted for 14 days. Two days after sponge removal the follicular population was re-evaluated and a second follicular aspiration was performed. Collected oocytes from the second OPU underwent in vitro maturation, fertilisation and culture. The number of large follicles was higher in Group M than in the control ewes during the first OPU and tended to be so (P = 0.06) at the second. Morphologically, oocytes collected from controls were of better quality than those from Group M; however, more oocytes collected from melatonintreated animals fertilised and developed in vitro. These results indicate that melatonin is a potent regulator of follicular development and oocyte competence during the anoestrous period of the ewe.

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Ovarian follicular development and oocyte quality in anestrous ewes treated with melatonin, a controlled internal drug release (CIDR) device and follicle stimulating hormone

Cited by 14 publications

References 31 publications

Effect of exogenous melatonin on the ovary, the embryo and the establishment of pregnancy in sheep

Effect of exogenous melatonin on the ovary, the embryo and the establishment of pregnancy in sheep

The effects of melatonin on in vitro oocyte competence and embryo development in sheep

Effects of melatonin treatment on follicular development and oocyte quality in Chios ewes — Short communication

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