Outpatient Ultra wide-field intravenous fundus fluorescein angiography in infants using the Optos P200MA scanning laser ophthalmoscope

Fung, Timothy H. M.; Yusuf, Imran H.; Smith, Lewis M.; Brett, Jon; Weston, Laura; Patel, Chetan K.

doi:10.1136/bjophthalmol-2013-304450

Cited by 18 publications

(11 citation statements)

References 8 publications

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“…11 This series is the first to describe non-contact ultrawidefield retinal imaging of infants with suspected AHT. The Optos P200MA scanning laser ophthalmoscope effectively documented acute and chronic AHT-related retinal haemorrhages, accurately defined the anatomical location of haemorrhage in one infant who was referred for consideration of vitrectomy, and excluded retinal haemorrhages and consequently AHT in a fifth infant.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10][11] Mydriasis was achieved with topical phenylephrine 2.5% and cyclopentolate 0.5%. Topical proxymetacaine 0.5% was instilled into each eye followed by insertion of a paediatric Lieberman speculum to part the eyelids, secured to the temple with Micropore tape.…”

Section: Retinal Imaging Protocolmentioning

confidence: 99%

“…We have not encountered any adverse events in infants undergoing non-contact Optos P200MA imaging in our centre-across any indication-using the 'flying baby position' in more than 100 examinations to date. [8][9][10][11] Larger numbers of Optos non-contact imaging studies are required before definitive conclusions can be made regarding safety.…”

Section: Non-contact Imagingmentioning

confidence: 99%

“…[8][9][10][11] Colour images of both eyes in this series took o5 min in each infant. Retinal haemorrhages are present bilaterally in 83% of infants with AHT 1 ; 2 images are required with Optos P200MA compared to 10-12 images with RetCam (typically 5-6 images are required for each eye to capture the entire retinal periphery which may be montaged).…”

Section: General Anaesthesia and Sedationmentioning

confidence: 99%

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Non-contact ultra-widefield retinal imaging of infants with suspected abusive head trauma

Yusuf

Barnes

Fung

et al. 2017

Eye

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Section: Discussionmentioning

confidence: 99%

Section: Retinal Imaging Protocolmentioning

confidence: 99%

Section: Non-contact Imagingmentioning

confidence: 99%

Section: General Anaesthesia and Sedationmentioning

confidence: 99%

See 2 more Smart Citations

Non-contact ultra-widefield retinal imaging of infants with suspected abusive head trauma

Yusuf

Barnes

Fung

et al. 2017

Eye

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“… 14 – 16 It has been shown that ultrawide-field FA (UWFA) is useful for the assessment of several retinal pathologies 17 including retinal vein occlusions, 18 diabetes, 19 , 20 uveitis, 21 retinal vasculitis, 22 choroidal masses, 23 , 24 retinal detachment, 25 and retinopathy of prematurity. 26 …”

Section: Introductionmentioning

confidence: 99%

Anti-VEGF treatment and peripheral retinal nonperfusion in patients with central retinal vein occlusion

Aghdam¹,

Reznicek²,

Sanjari³

et al. 2017

OPTH

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PurposeTo evaluate the association between the size of peripheral retinal nonperfusion and the number of intravitreal ranibizumab injections in patients with treatment-naïve central retinal vein occlusion (CRVO).MethodsFifty-four patients with treatment-naïve CRVO and macular edema were included. Each patient underwent a full ophthalmologic examination including optical coherence tomography imaging and ultrawide-field fluorescein angiography. Monthly intravitreal ranibizumab injections were applied according to the recommendations of the German Ophthalmologic Society. Two ophthalmologists quantified the areas of peripheral retinal nonperfusion (group 1= less than five disc areas, group 2= more than five disc areas). Correlation analyses between the size of nonperfusion with best-corrected visual acuity, central subfield thickness, and the number of intravitreal injections were performed.ResultsBest-corrected visual acuity improved significantly after intravitreal injections (P<0.001, both groups). Final central subfield thickness after treatment did not significantly differ between both groups (P=0.92, P=0.96, respectively). Mean number of injections in group 1 and group 2 was 4.12±2.73 and 9.32±3.84, respectively (P<0.001). There was a significant positive correlation between areas of nonperfusion and the number of injections in each group. (R=0.97, P<0.001; R=0.94, P<0.001, respectively).ConclusionPeripheral retinal nonperfusion in patients with CRVO correlates significantly with the number of needed intravitreal ranibizumab injections. Ultrawide-field fluorescein angiography is a useful tool for detection of peripheral retinal ischemia, which may have direct implications in the diagnosis, follow-up, and treatment of these patients.

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Ultra-Widefield Imaging of Retinal Hemorrhages Induced by Scleral Depression

2017

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An infant born at 24 weeks' gestation weighing 0.75 kg underwent examination with indirect ophthalmoscopy and scleral indentation for retinopathy of prematurity at 14 weeks' postnatal age. A second examiner noted widespread retinal hemorrhages (Figure , A). Ultrawidefield noncontact retinal imaging and fundus fluorescein angiography (0.1 mL/kg of 10% fluorescein) were performed (Optos PLC) using the flying baby position (Figure , B). 1,2 The infant was systemically well. Full blood cell count, coagulation studies, sickle cell screen, blood cultures, echocardiography, cerebral, and abdominal ultrasonography results were unremarkable. At 1 week, the superficial retinal hemorrhages had resolved. Plus disease developed in the right eye, and bilateral laser photocoagulation was undertaken.Intraretinal hemorrhages induced by scleral depression (during examination, contact imaging, or laser photocoagulation) have been reported in infants with active retinopathy of prematurity. [3][4][5] Here, we demonstrate its occurrence in the absence of active retinopathy of prematurity, excluded on fundus fluorescein angiography.

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Outpatient Ultra wide-field intravenous fundus fluorescein angiography in infants using the Optos P200MA scanning laser ophthalmoscope

Abstract: We have shown that UWF-IV-FFA can be successfully and safely performed in infants using the Optos P200MA system. It is a feasible new alternative to RetCam for obtaining an IV-FFA in the outpatients setting.

Cited by 18 publications

References 8 publications

Non-contact ultra-widefield retinal imaging of infants with suspected abusive head trauma

Non-contact ultra-widefield retinal imaging of infants with suspected abusive head trauma

Anti-VEGF treatment and peripheral retinal nonperfusion in patients with central retinal vein occlusion

Ultra-Widefield Imaging of Retinal Hemorrhages Induced by Scleral Depression

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