Non-contact ultra-widefield retinal imaging of infants with suspected abusive head trauma

Yusuf, Imran H.; Barnes, Jeff; Fung, Timothy H. M.; Elston, John; Patel, Chetan K.

doi:10.1038/eye.2017.2

Cited by 15 publications

(11 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…46,[50][51][52][53][54][55][56][57] RH in AHT cases commonly show multilayered and diffuse RH involving the peripheral retina in addition to the macular area. [58][59][60] , Suh and associates showed that infants delivered vaginally without complication may present with RH up to 50% of the cases, but most of these cases have only preretinal and intraretinal hemorrhages in the posterior pole with no signs of retinoschisis and vitreous hemorrhage that can be associated with vitreoretinal separation. 50,51 Furthermore, most of these RHs resolved within a few weeks, although a few isolated cases lasted up to 3 months of age.…”

Section: Results Of the Computer Model Show That Shakingmentioning

confidence: 99%

Determining the Tractional Forces on Vitreoretinal Interface Using a Computer Simulation Model in Abusive Head Trauma

Suh

Song

Mozafari

et al. 2021

American Journal of Ophthalmology

View full text Add to dashboard Cite

Abusive head trauma (AHT) is the leading cause of infant death and long-term morbidity from injury. The ocular consequences of AHT are controversial, and the pathophysiology of retinal research findings is still not clearly understood. It has been postulated that vitreoretinal traction plays a major role in the retinal findings. A computer simulation model was developed to evaluate the vitreoretinal traction and determine whether the distribution of forces in different layers and locations of the retina can explain the patterns of retinal hemorrhage (RH) seen in AHT.DESIGN: Computer simulation model study. METHODS: A computer simulation model of the pediatric eye was developed to evaluate preretinal, intraretinal, and subretinal stresses during repetitive shaking. This model was also used to examine the forces applied to various segments along blood vessels.RESULTS: Calculated stress values from the computer simulation ranged from 3-16 kPa at the vitreoretinal interface through a cycle of shaking. Maximal stress was observed at the periphery of the retina, corresponding to areas of multiple vessel bifurcations, followed by the posterior pole of the retina. Stress values were similar throughout all 3 layers of the retina (preretinal, intraretinal, and subretinal layers).CONCLUSIONS: Ocular manifestations from AHT revealed unique retinal characteristics. The model predicted stress patterns consistent with the diffuse retinal hemorrhages (RH) typically found in the posterior pole and around the peripheral retina in AHT. This computer model demonstrated that similar stress forces were produced in different layers of the retina, consistent with the finding that retinal hemorrhages are often found in multiple layers of the retina. These data can help explain the RH patterns commonly found in

show abstract

Section: Results Of the Computer Model Show That Shakingmentioning

confidence: 99%

Determining the Tractional Forces on Vitreoretinal Interface Using a Computer Simulation Model in Abusive Head Trauma

Suh

Song

Mozafari

et al. 2021

American Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…The biomarkers of abusive head trauma (AHT) is another example. The most common retinal manifestation of AHT is multiple retinal hemorrhages in multiple layers of the retina [41]. Matching the captured images onto the full retina image, The hemorrhagic spots can be easily segmented after the subtraction of the current retina regions and previous status.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

RetinaMatch: Efficient Template Matching of Retina Images for Teleophthalmology

Gong

Erichson

Kelly

et al. 2019

IEEE Trans. Med. Imaging

View full text Add to dashboard Cite

Retinal template matching and registration is an important challenge in teleophthalmology with low-cost imaging devices. However, the images from such devices generally have a small field of view (FOV) and image quality degradations, making matching difficult. In this work, we develop an efficient and accurate retinal matching technique that combines dimension reduction and mutual information (MI), called RetinaMatch. The dimension reduction initializes the MI optimization as a coarse localization process, which narrows the optimization domain and avoids local optima. The effectiveness of RetinaMatch is demonstrated on the open fundus image database STARE with simulated reduced FOV and anticipated degradations, and on retinal images acquired by adapter-based optics attached to a smartphone. RetinaMatch achieves a success rate over 94% on human retinal images with the matched target registration errors below 2 pixels on average, excluding the observer variability. It outperforms the standard template matching solutions. In the application of measuring vessel diameter repeatedly, single pixel errors are expected. In addition, our method can be used in the process of image mosaicking with area-based registration, providing a robust approach when the feature based methods fail. To the best of our knowledge, this is the first template matching algorithm for retina images with small template images from unconstrained retinal areas. In the context of the emerging mixed reality market, we envision automated retinal image matching and registration methods as transformative for advanced teleophthalmology and long-term retinal monitoring.

show abstract

“…The non-contact high-resolution ultra-wide-field system has other advantages for pediatricians, neonatologists, and ophthalmologists in the evaluation of premature or full-term babies. Yusuf et al 10 used Optomap images to show the retinal features of 10 eyes of 5 consecutive infants (aged 1-15 months) with suspected abusive head trauma. It is indisputable that to document and record any abnormalities in patients is a medicolegal obligation.…”

Section: Discussionmentioning

confidence: 99%

Binocular Indirect Ophthalmoscopy Complements Non-contact Wide-field Imaging with Optos to Treat a Baby Outside ETROP Guidelines

Özdemir

Patel

2018

tjo

View full text Add to dashboard Cite

We report a male premature baby who was born at 24 weeks gestation weighing 600 grams. There was bilateral stage 2, zone 2 retinopathy of prematurity (ROP) without plus disease at 38 weeks postmenstrual age. Ultra-wide-field Optomap images obtained 1 week later showed no change in ROP stage. At 40 weeks postmenstrual age, stage 3, zone 2 ROP was detected using binocular indirect ophthalmoscopy and documented using Optos. Minor tortuosity and dilation of vessels was interpreted as pre-plus disease. One week later, at 41 weeks postmenstrual age, Optomap images identified progressive extraretinal fibroproliferation in the nasal quadrant. As a result, the baby was treated with fundus laser photocoagulation.

show abstract

Non-contact ultra-widefield retinal imaging of infants with suspected abusive head trauma

Cited by 15 publications

References 14 publications

Determining the Tractional Forces on Vitreoretinal Interface Using a Computer Simulation Model in Abusive Head Trauma

Determining the Tractional Forces on Vitreoretinal Interface Using a Computer Simulation Model in Abusive Head Trauma

RetinaMatch: Efficient Template Matching of Retina Images for Teleophthalmology

Binocular Indirect Ophthalmoscopy Complements Non-contact Wide-field Imaging with Optos to Treat a Baby Outside ETROP Guidelines

Contact Info

Product

Resources

About