“…The signs and symptoms of DVT are non-specific and may be associated with other lower extremity disorders, including lymphedema, PTS, superficial venous thrombosis, cellulitis, musculoskeletal trauma, and Baker’s cysts. Among patients referred to the vascular laboratory for exclusion of DVT, only 12%–31% will have a positive ultrasound (US) study [ 10 – 12 ].The most common presenting symptoms have a wide range of reported sensitivities and specificities: calf pain, sensitivity 75%–91% and specificity 3%–87%; and calf swelling, sensitivity 35%–97% and specificity 8%–88% [ 13 – 18 ]. None of the signs or symptoms is sufficiently sensitive or specific, either alone or in combination, to accurately diagnose or exclude thrombosis [ 19 ].…”