Tissue Inhibitor of Metalloproteinase‐1 (<i>TIMP‐1</i>) Polymorphisms in a Caucasian Population with Abdominal Aortic Aneurysm

Hinterseher, Irene; Kuhlisch, Eberhard; Kg, Schmidt; Pilarsky, Christian; Schneiders, Wolfgang; Saeger, H. D.; Bergert, H.

doi:10.1007/s00268-007-9209-x

Cited by 34 publications

(21 citation statements)

References 52 publications

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“…Decreased in G allele (2-fold) Yoon et al [24] MMP-21 C572T Ala to Val substitution in enzymes catalytic domain Effect unclear Shagisultanova et al [29] TIMP-1 372 C/T Unknown, located in exon 5, no effect on transcription or amino-acid sequence Effect unclear Hinterseher et al [26] TIMP-2 -418 G/C G to C substitution results in disruption of Sp-1 binding site Decreased in C allele 2 Hirano et al [30] TIMP-2 303C/T Unknown, located in exon 3, no effect on transcription or amino-acid sequence Effect unclear Kubben et al [14] 1…”

Section: Gastric Cancermentioning

confidence: 99%

Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer

Langers

Verspaget²,

Hommes³

et al. 2011

WJGO

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Matrix metalloproteinases (MMPs) are implicated in cancer development and progression and are associated with prognosis. Single-nucleotide polymorphisms (SNPs) of MMPs, most frequently located in the promoter region of the genes, have been shown to influence cancer susceptibility and/or progression. SNPs of MMP-1, -2, -3, -7, -8, -9, -12, -13 and -21 and of the tissue inhibitor of metalloproteinases (TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract tumors. The contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper.

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Section: Gastric Cancermentioning

confidence: 99%

Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer

Langers

Verspaget²,

Hommes³

et al. 2011

WJGO

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“…It is noteworthy, that the genotyping results were analyzed for male and female patients separately due to the fact, that TIMP-1 gene is located on the X chromosome. To date, the association with aortic aneurysm has been suggested for two polymorphisms in gene for TIMP-1 (434 C/T and rs2070584 T/C) (Ogata et al, 2005) and two in TIMP-2 (a promoter SNP -479 C/T, and 573 G/A, but in male patients group only) (Wang et al, 1999;Hinterseher et al, 2007). Nevertheless, since the mentioned analyses concerned relatively small groups, this issue still requires additional investigation (Sandford et al, 2007;Saratzis et al, 2011).…”

Section: Inhibition Of Mmpsmentioning

confidence: 99%

Matrix metalloproteinases in aortic aneurysm - executors or executioners?

Grzela¹,

Bikowska²,

Litwiniuk³

2011

Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture

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“…The TIMP-1 372T > C polymorphism in exon 5 has been suggested to account for the great majority of polymorphisms in the gene, whereas the other polymorphisms have a very low frequency of occurrence (Hinterseher et al, 2007). Information on the possible influence of polymorphism in the gene for TIMP-1, on serum levels of TIMP-1, and on LV function in the acute phase of MI has not yet been published.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute Heart Failure and Left Ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention

Goldbergová

Pařenica

Jarkovský

et al. 2012

Genetic Testing and Molecular Biomarkers

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Aims: Tissue inhibitors of metalloproteinase (TIMPs) bind to active matrix metalloproteinase (MMPs), and thereby inhibit their proteolytic activity. We investigated the role of polymorphisms in the gene for TIMP-1 and serum levels of TIMP-1 in association with postmyocardial infarction (MI), left ventricular (LV) dysfunction, and symptoms of acute heart failure (AHF) in patients treated with primary percutaneous coronary intervention. Methods: In total, 556 patients with STEMI were evaluated. Levels of TIMP-1 were measured at admission and 24 h after MI onset. The TIMP-1 exon 5 SNP rs4898 (F124F with T > C) located at X chromosome was assayed. Results: TIMP-1 levels were higher for men with AHF as well as for men with LV dysfunction (ejection fraction [EF] < 40%). According to multivariate analysis, the TIMP-1 level was a factor with an independent negative relationship to EF and AHF in men. An independent relationship between exon 5 TIMP-1 gene polymorphism and EF, AHF or TIMP-1 level was not documented. Conclusion: These results provide evidence that a higher level of circulating TIMP-1 is independently associated with worse EF and AHF.

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Tissue Inhibitor of Metalloproteinase‐1 (TIMP‐1) Polymorphisms in a Caucasian Population with Abdominal Aortic Aneurysm

Abstract: Our analysis of the entire coding region and selected parts of the promoter of the TIMP-1 gene failed to show an association between genetic polymorphisms and AAA, suggesting that variations in the TIMP-1 gene do not contribute to the development of AAA.

Cited by 34 publications

References 52 publications

Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer

Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer

Matrix metalloproteinases in aortic aneurysm - executors or executioners?

The Association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute Heart Failure and Left Ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention

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