Diagnosis and Treatment of Lower Extremity Deep Vein Thrombosis: Korean Practice Guidelines

Min, Seung-Kee; Kim, Young Hwan; Joh, Jin Hyun; Kang, Jin Mo; Park, Ui Jun; Kim, Hyung-Kee; Chang, Jeong-Hwan; Park, Sang Jun; Kim, Jang Yong; Bae, Jae Ik; Choi, Sun Young; Kim, Chang Won; Park, Sung Il; Yim, Nam Yeol; Jeon, Yong Sun; Yoon, Hyun-Ki; Park, Ki Hyuk

doi:10.5758/vsi.2016.32.3.77

Cited by 50 publications

(38 citation statements)

References 215 publications

(220 reference statements)

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“…Initially, following the criteria, patients were classified into high, intermediate and low-risk groups. Currently, Doppler venous ultrasound is the best imaging modality for diagnosis of DVT [ 23 ]. Others like contrast venography and magnetic resonance venography are also being employed, but they have certain limitations [ 24 ].…”

Section: Reviewmentioning

confidence: 99%

Thromboprophylaxis in Intensive Care Unit Patients: A Literature Review

Ejaz

Ahmed

Tasleem

et al. 2018

Cureus

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Thromboembolism is a major complication in hospitalized patients. Intensive care unit (ICU) patients have a greater risk of thrombotic events due to additional risk factors such as immobilization, mechanical ventilation, and central catheters. The diagnosis and management of deep vein thrombosis (DVT) and pulmonary embolism (PE) in critically ill patients are challenging and these conditions are associated with high mortality. Medical thromboprophylaxis with low molecular weight heparin (LMWH) as well as unfractionated heparin (UFH) has been shown to reduce the incidence of thromboembolic events in such patients. For patients with high risk of bleeding, mechanical thromboprophylaxis can be used. Literature database was conducted on Medline for articles published up to 2018 using particular search terms such as thromboprophylaxis and venous thromboembolism in ICU patients. The following review summarizes the existing data regarding thromboprophylaxis in ICU patients with special consideration to the use of mechanical prophylaxis and pharmacologic prophylaxis using heparin products.

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Section: Reviewmentioning

confidence: 99%

Thromboprophylaxis in Intensive Care Unit Patients: A Literature Review

Ejaz

Ahmed

Tasleem

et al. 2018

Cureus

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“…Some DVT patients have no obvious symptoms, and thus escape timely diagnosis and treatment. Consequently, clinical manifestations must be combined with imaging and biomarkers to assess potential thrombosis [ 3 , 4 ]. What’s worse, 20% to 50% of patients suffering from DVT will develop PTS, a chronic and potentially devastating complication of DVT; 5% to 10% patients will develop severe PTS, and 30% will have a recurrence within the next decade [ 1 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Combination of Circulating miRNA-320a/b and D-Dimer Improves Diagnostic Accuracy in Deep Vein Thrombosis Patients

Jiang

Wang

et al. 2018

Med Sci Monit

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BackgroundD-dimer tests have been widely used to rule-out deep venous thrombosis (DVT), but with low specificity. Circulating microRNAs (miRNAs) are novel promising biomarkers in diverse diseases. The purpose of our study was to identify the diagnostic abilities of circulating miRNA-320a/b and to assess their correlation with plasma D-dimer in DVT and post-thrombotic syndrome (PTS) patients.Material/MethodsPlasma samples were taken from 30 DVT patients, 30 PTS patients, and 30 age- and sex-matched healthy volunteers. Quantitative real-time PCR (qPCR) assay and turbidimetric immunoassay were conducted to assess the concentrations of miRNA-320a/b and D-dimer in plasma.ResultsCirculating miRNA-320a and miRNA-320b were significantly upregulated in DVT patients with fold changes of 1.58 and 1.79, respectively. The receiver operating characteristic (ROC) curve analysis showed area under the curve (AUC) values of 0.70 (95% CI: 0.56–0.83) for miRNA-320a and 0.79 (95% CI: 0.67–0.90) for miRNA-320b. Moreover, plasma levels of miRNA-320b were associated with D-dimer values (r=0.52, 95% CI: 0.19–0.74) in DVT. However, no significant changes in plasma miRNA-320a/b and D-dimer were detected in PTS patients.ConclusionsCompared with controls, circulating miRNA-320a/b was differentially expressed in DVT. Simultaneous detection of miRNA-320a/b with D-dimer may improve diagnostic accuracy of DVT.

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“…It is significantly a cause of mortality and morbidity in the long term due to post-thrombolytic events. [1][2][3] The main factors for venous thrombosis are endothelial damage, changes in blood flow and hypercoagulability. 2 This is caused by changes in blood flow, blood viscosity, especially hyperviscosity, in addition, increased shear stress in hyperviscosity causes endothelial damage and thrombosis.…”

Section: The Relationship Between Whole Blood Viscosity and Deep Veinmentioning

confidence: 99%