The Relationship Between Whole Blood Viscosity and Deep Vein Thrombosis

Güneş, Hakan; Kirişçi, Mehmet

doi:10.5336/cardiosci.2018-61921

Cited by 7 publications

(3 citation statements)

References 10 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased blood viscosity is a risk factor for deep vein thrombosis [3,39]. Blood flow is slow in veins; therefore, blood viscosity becomes relatively high (viscosity = shear stress/shear rate).…”

Section: Infection and Venous Thrombosismentioning

confidence: 99%

The Role of Blood Viscosity in Infectious Diseases

Sloop¹,

Mast²,

Pop³

et al. 2020

Cureus

View full text Add to dashboard Cite

Blood viscosity is increased by elevated concentrations of acute phase reactants and hypergammaglobulinemia in inflammation. These increase blood viscosity by increasing plasma viscosity and fostering erythrocyte aggregation. Blood viscosity is also increased by decreased erythrocyte deformability, as occurs in malaria. Increased blood viscosity contributes to the association of acute infections with myocardial infarction (MI), venous thrombosis, and venous thromboembolism. It also increases vascular resistance, which decreases tissue perfusion and activates stretch receptors in the left ventricle, thereby initiating the systemic vascular resistance response. This compensates for the increased vascular resistance by vasodilation, lowering hematocrit, and decreasing intravascular volume. This physiological response causes the anemias associated with malaria, chronic inflammation, and other chronic diseases. Since tissue perfusion is inversely proportional to blood viscosity, anemia may be beneficial as it increases tissue perfusion when erythrocyte aggregating factors or erythrocytes with decreased deformability are present in the blood.

show abstract

Section: Infection and Venous Thrombosismentioning

confidence: 99%

The Role of Blood Viscosity in Infectious Diseases

Sloop¹,

Mast²,

Pop³

et al. 2020

Cureus

View full text Add to dashboard Cite

show abstract

“…[ 16 ] In another study, WBV was found to be related with susceptibility for deep vein thrombosis. [ 17 ] Along with the development of endothelial dysfunction, lipoproteins start to accumulate in subendothelial region and at the end of this inflammatory process atherom plaques occur. There are substantial data demonstrating the correlation between increased inflammatory gene expression and LSR.…”

Section: Discussionmentioning

confidence: 99%

Can whole blood viscosity predict the development of acute mesenteric arterial thrombosis?

Gül

Küçük

2023

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

BACKGROUND: Acute mesenteric ischemia is a serious condition with high mortality rate, resulting internal organ damage and intestinal necrosis due to sudden occlusion in the arteries feeding the abdominal solid organs and intestines. The most common causes of acute mesenteric artery ischemia are embolic processes and thrombosis that develops on the basis of primary mesenteric artery atherosclerosis. Whole blood viscosity (WBV) was defined by De Simon and could be calculated with a formula that consists of total plasma protein and hematocrit (HCT). In our study, we aimed to investigate the predictive value of WBV for acute mesenteric ischemia caused by primary mesenteric artery occlusion. METHODS:Between January 2015 and February 2021, a total of 55 patients with a retrospective diagnosis of acute mesenteric ischemia (AMI) and 50 healthy volunteers as a control group were included in the study. WBV was calculated with the De Simon formula using the HCT and plasma protein levels from the blood tests of healthy volunteers and patients at the time of admission with acute abdomen. RESULTS:No significant differences between the two groups in terms of baseline demographic characteristics except the prevalence of age (72.1±12.4 vs. 65.7±6.4; p<0.001) and hypertension (40% vs. 23% p=0.002). AMI patients had significantly higher WBV values both at low shear rate (LSR) ([46.3±21.7 vs. 33.4±13.1, p<0.001] and high shear rate [HSR] [16.5±11 vs. 15.8±0.7, p<0.001]). The univariate analysis identified several variables for predicting AMI including age (odds ratio [OR]: 1.066 confidence interval [CI]:

show abstract

“…The impact of a massive increase in the relative mass of RBC is an increase in the viscosity of whole blood, primarily by increasing the number of particles per unit of blood volume and, therefore, increasing the peripheral resistance to blood flow [ 64 ]. Viscosity is defined as the ratio between the shearing effort and the shear rate and is a risk factor for deep venous thrombosis, creating a procoagulant state through thrombocytosis and increasing the concentration of the circulating tissue factor [ 65 ]. Mean corpuscular volume is considered to have qualitative effects on blood rheology, rather than quantitative effects, such as hematocrit [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Has COVID-19 Modified the Weight of Known Systemic Inflammation Indexes and the New Ones (MCVL and IIC) in the Assessment as Predictive Factors of Complications and Mortality in Acute Pancreatitis?

et al. 2022

View full text Add to dashboard Cite

We aimed at evaluating the prognostic capacity of the inflammatory indices derived from routine complete blood cell counts in two groups of patients with acute pancreatitis from two different time periods, before and during the COVID-19 pandemic, when a high incidence of complications with surgical risk and mortality was found. Two new markers were introduced: the mean corpuscular volume to lymphocyte ratio (MCVL) and the cumulative inflammatory index (IIC), which were calculated at a baseline in the two groups of patients. Of the already established markers, none of them managed to effectively predict the complications with surgical risk and mortality, with a decrease of less than 50% in specificity in the peri-COVID group. The MCVL had the best prediction of complications with surgical risk in both the pre-COVID and peri-COVID groups, validated it as an independent factor by multivariate analysis. The IIC had the best prediction of mortality in both periods and was proven to be an independent factor by multivariate analysis. As the IIC predicted death best, we tested the occurrence of death and found that patients with PA who had an IIC > 12.12 presented a risk of death 4.08 times higher in the pre-COVID group and 3.33 times higher in the peri-COVID group. The new MCVL and IIC independent markers had a superior sensitivity and specificity in predicting surgical risk complications and, respectively, mortality in the group of patients with acute pancreatitis during the COVID-19 pandemic, which makes them widely applicable in populations with modified immune and inflammatory status. Conclusions: In patients with acute pancreatitis, MCVL has a significant predictive value regarding complications with surgical risk (abscess, necrosis, and pseudocyst), and the IIC has a significant predictive value for mortality.

show abstract

The Relationship Between Whole Blood Viscosity and Deep Vein Thrombosis

Abstract: The forgotten variable of shear stress in mitral annular calcification: whole blood viscosity. Med

Cited by 7 publications

References 10 publications

The Role of Blood Viscosity in Infectious Diseases

The Role of Blood Viscosity in Infectious Diseases

Can whole blood viscosity predict the development of acute mesenteric arterial thrombosis?

Has COVID-19 Modified the Weight of Known Systemic Inflammation Indexes and the New Ones (MCVL and IIC) in the Assessment as Predictive Factors of Complications and Mortality in Acute Pancreatitis?

Contact Info

Product

Resources

About