Outpatient Antimicrobial Therapy for Infective Endocarditis is Safe

Effect of Implementing Educational Program on Nurses' performance and Clinical Outcomes for Patients with Acute Infective Endocarditis

“…Also, this finding showed that the educational program had a good impact on improving nurses' knowledge, which could be due to the concise presentation of each session using simple Arabic language, clear educational methods, instructional media, and the availability of researcher in the field for more clarification, and frequent repetition to fix the knowledge. The study was in line with Dylan et al (2021) (33) , who showed that the educational program improves nurses" knowledge and performance, but this finding disagreed with David et al (2015) (34) ,who revealed that critical care nurses perceive various barriers to successfully implementing evidence-based emergency interventions for critically ill patients, as well as the educational needs necessary to overcome such challenges. Regarding the acquisition of nursing performance, the current study showed that that none of nurses had good practice scores about acute Infective Endocarditis in the pretest , while the majority of nurses had good practice score immediately and after one month of program respectively.…”

Efficacy and safety of outpatient parenteral antibiotic therapy in patients with infective endocarditis: a meta-analysis

“…Current research data show that OPAT has a good therapeutic effect on IE patients, and it is expected that OPAT will continue to show a good effect in the treatment of IE patients in the future. OPAT has also shown many benefits, such as providing significant cost effectiveness to inpatient management [ 1 , 13 , 16 , 19 , 20 ], not only by reducing the cost of treatment for patients, but also by bringing benefits to the healthcare delivery system. A study from Europe showed that the use of OPAT therapy for IE reduced costs by approximately €15,000 per patient [ 16 ].…”

“…Outpatient parenteral antimicrobial therapy (OPAT) refers to the monitored administration of parenteral antibiotics in non-inpatient or outpatient settings ( e.g ., clinic, home, office), and besides shortening the duration of hospitalization, a major reason for OPAT use that it is a strategy to conserve antibiotic expenditures [ 1 , 8 ]. OPAT can be used to treat a wide variety of infections, including skin and soft tissue infections, bone and joint infections, endocarditis, gram-positive bacteremia, increasingly, drug-resistant gram-negative infections, and other specific fungal infections (e.g., cryptococcosis, candidiasis), viral infections (e.g., cytomegalovirus), or protozoa infections (e.g., Leishmania) [ 8 ].…”

“…Infective endocarditis (IE) is a serious infectious disease with significant associated mortality, and morbidity and results in considerable medical burden to patients. The common pathogenic bacteria causing IE include Staphylococcus spp (Staphylococcus aureus predominates), Streptococcus spp and Enterococcus spp, and by other less common organisms such as the HACEK Gram-negative bacilli (Haemophilus aphrophilus, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae) and fungi (Candida spp, Aspergillus spp) [1][2][3][4]. The annual incidence of IE is 3-7 cases per 100,000 population, and, despite advances in diagnosis and treatment, mortality in IE patients remains high, with a reported mortality rate of 15-20% in hospital and about 40% per year during follow-up [5][6][7].…”

Pediatric Infective Endocarditis: A Literature Review

“…Outpatient treatment could be considered in children without complications or high-risk factors, with negative control blood cultures, who remain afebrile, and in whom it is possible to guarantee therapeutic adherence, the collaboration of parents, and close supervision by cooperative parents and a home health nurse [ 83 , 84 ].…”