Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study

Havet, Anaïs; Zerimech, Farid; Sanchez, Margaux; Siroux, Valérie; Moual, Nicole Le; Brunekreef, Bert; Stempfelet, Morgane; Künzli, Nino; Jacquemin, Bénédicte; Matran, Régis; Nadif, Rachel

doi:10.1183/13993003.02036-2017

Cited by 26 publications

(18 citation statements)

References 38 publications

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“…The way and the strength of the association with back-extrapolated PM 10 were the same, but the association was not significant due to the small effective. Previously, we found that 8-isoprostane in exhaled breath condensate, a matrix close to the lungs, increased significantly with PM 2.5 exposure in the EGEA study [23]. 8-isoprostane is a biomarker of damages related to oxidative stress, and a specific product of lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

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Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

Havet

Zerimech

et al. 2019

Environ Health

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BackgroundEvidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an oxidative stress-related biomarker), as potential mediators, in the associations between outdoor air pollution and persistent asthma.MethodsAnalyses were conducted in 204 adult asthmatics followed up in the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Persistent asthma was defined as having current asthma at EGEA2 (baseline, 2003–2007) and EGEA3 (follow-up, 2011–2013). Exposures to nitrogen dioxide, nitrogen oxides, road traffic, particulate matter with a diameter ≤ 10 μm (PM10) and ≤ 2.5 μm were estimated by ESCAPE models (2009–2010), and ozone (O3) by IFEN models (2004). We used a mediation analysis to assess the mediated effect by FlOPs levels and the interaction between FlOPs levels and air pollution.ResultsFlOPs levels increased with PM10 and O3 (adjusted β = 0.04 (95%CI 0.001–0.08), aβ = 0.04 (95%CI 0.009–0.07) per 10 μg/m3, respectively), and the risk of persistent asthma increased with FlOPs levels (aOR = 1.81 (95%CI 1.08–3.02)). The risk of persistent asthma decreased with exposures to NO2, NOx and PM2.5 (aOR ranging from 0.62 to 0.94), and increased with exposures to PM10, O3, O3-summer and road traffic, the greater effect being observed for O3 (aOR = 1.78, 95% CI 0.73–4.37, per 10 μg/m3). Using mediation analysis, we observed a positive total effect (aOR = 2.16, 95%CI 0.70–11.9), a positive direct effect of O3 on persistent asthma (OR = 1.68, 95%CI 0.57–7.25), and a positive indirect effect mediated by FIOPs levels (aOR = 1.28 (95%CI 1.01–2.29)) accounting for 41% of the total effect.ConclusionsOur results add insights on the role of oxidative stress in the association between air pollution and persistent asthma.

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Section: Discussionmentioning

confidence: 99%

“…Although the association between O 3 and persistent asthma was non-significant, the strength of the association between O 3 and persistent asthma, and previous results obtained in the EGEA study guided our decision. Indeed, O 3 was associated with severe asthma [18], uncontrolled asthma [28] and current asthma [23] in adults.…”

Section: Discussionmentioning

confidence: 99%

Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

Havet

Zerimech

et al. 2019

Environ Health

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“…Increased levels of prostaglandins cause more pain. Recent animal and human studies have linked excessive prostaglandins with short-and long-term exposures to PM 2.5 and other air pollutants [67][68][69][70]. Nevertheless, the exact biological mechanisms underlying the reported associations remain elusive and deserve further research.…”

Section: Major Disease Category Annual Reduction In Hospital Admissiomentioning

confidence: 99%

Ambient air pollution and cause-specific risk of hospital admission in China: A nationwide time-series study

Shi²,

Zhu

et al. 2020

PLoS Med

122

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Background The impacts of air pollution on circulatory and respiratory systems have been extensively studied. However, the associations between air pollution exposure and the risk of noncommunicable diseases of other organ systems, including diseases of the digestive, musculoskeletal, and genitourinary systems, remain unclear or inconclusive. We aimed to systematically assess the associations between short-term exposure to main air pollutants (fine particulate matter [PM 2.5 ] and ozone) and cause-specific risk of hospital admission in China over a wide spectrum of human diseases. Methods and findings Daily data on hospital admissions for primary diagnosis of 14 major and 188 minor disease categories in 252 Chinese cities (107 cities in North China and 145 cities in South China) from January 1, 2013, to December 31, 2017, were obtained from the Hospital Quality Monitoring System of China (covering 387 hospitals in North China and 614 hospitals in South China). We applied a 2-stage analytic approach to assess the associations between air pollution and daily hospital admissions. City-specific associations were estimated with quasi-Poisson regression models and then pooled by random-effects meta-analyses. Each disease category was analyzed separately, and the P values were adjusted for multiple comparisons. A total of 117,338,867 hospital admissions were recorded in the study period. Overall, 51.7% of the hospitalized cases were male, and 71.3% were aged <65 years. Robust positive associations were found between short-term PM 2.5 exposure and hospital

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“…(Modified after [29] studies report statistically significantly higher risks for asthma in increased NO2 exposure [43][44][45], as well as in a subpopulation of atopic individuals [46]. Other studies, some of which evaluate several cohorts together [47], reveal increased risks, which, however, are not statistically significant [47][48][49][50]. The handful of studies that have investigated the effects of PM2.5 on the new onset of asthma in adulthood found nonstatistically significantly increased risks [47,49].…”

Section: Asthmamentioning

confidence: 99%

Air pollutants and primary allergy prevention

Heinrich

2018

Allergo J Int

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Background Air pollutants such as particulate matter (PM2.5) and nitrogen dioxide (NO2) in outdoor air have long been suspected of causing the development of asthma and allergic rhinitis. However, a variety of systematic reviews have reached different conclusions in the last 15 years on whether these air pollutants do in actual fact play a causal role in the onset of asthma, allergic rhinitis, and eczema. Methods Based on published systematic reviews and the most recent publications, the current state of knowledge on epidemiological evidence is presented and the potential for primary prevention of these allergic diseases by reducing or avoiding exposure to these air pollutants evaluated. Results Despite conducting an extensive literature search, analyzing the most recent results, and focusing on the birth cohort studies most relevant to the question in hand, epidemiological results do not adequately support the concept of a causal relationship between the two air pollutants in question, PM2.5 and NO2, and asthma. Epidemiological studies predominantly show no effect of these air pollutants on allergic sensitization and the onset of allergic rhinitis. The small number of studies that have investigated the link between air pollutants and eczema largely revealed there to be no link. Conclusion If the evidence for the causal role of air pollutants in the onset of allergies is inconclusive, one must assume that it is probably not possible to achieve

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Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study

Cited by 26 publications

References 38 publications

Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

Ambient air pollution and cause-specific risk of hospital admission in China: A nationwide time-series study

Air pollutants and primary allergy prevention

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