Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

Havet, Anaïs; Li, Zhen; Zerimech, Farid; Sanchez, Margaux; Siroux, Valérie; Moual, Nicole Le; Brunekreef, Bert; Künzli, Nino; Jacquemin, Bénédicte; Varraso, Raphäelle; Matran, Régis; Nadif, Rachel

doi:10.1186/s12940-019-0532-0

Cited by 17 publications

(9 citation statements)

References 26 publications

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“…For those who never had asthma by age Havet et al found increases in adult plasma levels of fluorescent oxidation products (FLOPs) after O 3 and PM 10 exposures and that this increase was associated with a risk for persistent asthma. These findings strengthen the role that FLOP levels play in inducing oxidative stress [103]. These findings are in accordance with previous studies of uncontrolled asthma [98], current asthma [97], and severe asthma in adults [104].…”

Section: Adult Asthmasupporting

confidence: 92%

External Environmental Pollution as a Risk Factor for Asthma

Chatkin

Corrêa

Santos

2021

Clinic Rev Allerg Immunol

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Section: Adult Asthmasupporting

confidence: 92%

External Environmental Pollution as a Risk Factor for Asthma

Chatkin

Corrêa

Santos

2021

Clinic Rev Allerg Immunol

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“…The common mechanistic explanations for our findings are the induction of pulmonary oxidative stress and antioxidant depletion, inflammation, and activation of receptors of the bronchial epithelium, and an increase in Th2 and Th17 cytokines. Additional effects may involve epigenetic changes, pulmonary microbiome modifications, and interaction of NOx with environmental antigens to enhance their activity [17,[35][36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Associations of Exposure to Nitrogen Oxides with Prevalent Asthma and Other Atopic Diseases in Israel

et al. 2021

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Childhood exposure to nitrogen oxides (NOx) is considered a risk factor for the onset of asthma. However, associations of this exposure with other atopic diseases and factors that modify this association are less clear. We aimed to study associations between exposure to NOx and the prevalence of atopic diseases in Israeli adolescents using a cross-sectional design. The study population comprised all Israeli-born adolescents whose medical status was evaluated for mandatory military recruitment during 1967–2017 (n = 2,523,745), of whom 5.9% had prevalent asthma. We based the exposure assessments on a land-use regression model and estimated associations using multivariable logistic regression models. Across all periods, mean exposure to NOx from birth to adolescence was associated with prevalent asthma at the examination in a dose-response manner, with an odds ratio for the upper quintile of 1.61 (95% CI: 1.56–1.67), in comparison to the lowest quintile. Associations were stronger in males and in lower socioeconomic strata. We found the strongest associations for asthma with comorbid rhinitis, with an almost twofold increase in the odds of upper versus lower quintile of exposure (odds ratio = 1.96, 95% CI: 1.82–2.11). Rhino-conjunctivitis and allergic atopic dermatitis suggested a possible threshold level with NOx. Capsule Summary: Research indicates that half of the global population will suffer from an allergic condition at some point in life. Childhood exposure to nitrogen oxides is a risk factor for the onset of asthma. The association between exposure and allergic diseases other than asthma is unclear. We demonstrate a strong, dose-response relationship between exposure and a group of allergic outcomes, using data comprising 2.5 million subjects over 50 years. The large health benefits from clean air should motivate governments to prioritize mitigation measures.

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“…Previous epidemiologic studies have reported associations of air pollution exposure with oxidative stress in the circulatory system and lower respiratory tract in patients with asthma. − Increased oxidative stress in the lower respiratory tract has also been associated with increased airway inflammation, a hallmark of asthma exacerbation . We hypothesize that O 3 and/or PM 2.5 can exert oxidative damage in the nose upon entering the respiratory tract.…”

Section: Introductionmentioning

confidence: 88%

Malondialdehyde in Nasal Fluid: A Biomarker for Monitoring Asthma Control in Relation to Air Pollution Exposure

Cui

et al. 2020

Environ. Sci. Technol.

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Fine particulate matter (PM2.5) and ozone (O3) may exert oxidative damage in the nose, which is hypothesized to be associated with worsened asthma symptoms. This study, hence, is to explore whether an oxidative stress biomarker, malondialdehyde (MDA) in the nasal fluid, has the potential to aid personalized asthma control. In a panel study of 43 asthmatic children, 5–13 years old, each child was measured 4 times with a 2-week interval between consecutive clinic visits. At each visit, nasal fluid and urine samples were collected, and fractional exhaled nitric oxide (FeNO) was measured as a biomarker of pulmonary inflammation. In addition to nasal MDA, urinary MDA and 8-hydroxy-2′-deoxyguanosine (8-OHdG) were measured as biomarkers of systemic oxidative stress. We also assessed asthma symptoms using the Childhood Asthma-Control Test (C-ACT). We found that interquartile range (IQR) increases in 24 h average personal PM2.5 exposure (22.2–33.5 μg/m3), estimated 0 to 5 days prior to a clinic visit, were associated with increased nasal MDA concentrations by 38.6–54.9%. Similarly, IQR increases in 24 h average personal O3 exposure (7.7–8.2 ppb) estimated 2 to 4 days prior were associated with increased nasal MDA by 22.1–69.4%. Only increased PM2.5 exposure was associated with increased FeNO. Increased nasal MDA concentration was associated with decreased total and individual C-ACT scores, indicating worsening of asthma symptoms. However, no significant associations were observed between urinary MDA or 8-OHdG and C-ACT scores. The results confirm that oxidative stress plays an important role in linking air pollution exposure and adverse respiratory health effects. These findings support that MDA in the nasal fluid may serve as a useful biomarker for monitoring asthma status, especially in relation to PM2.5 and O3 exposures, two known risk factors of asthma exacerbation.

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Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

Cited by 17 publications

References 26 publications

External Environmental Pollution as a Risk Factor for Asthma

External Environmental Pollution as a Risk Factor for Asthma

Associations of Exposure to Nitrogen Oxides with Prevalent Asthma and Other Atopic Diseases in Israel

Malondialdehyde in Nasal Fluid: A Biomarker for Monitoring Asthma Control in Relation to Air Pollution Exposure

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