Outcomes of stage IIB osteosarcoma treated by limb salvage surgery using extracorporeally irradiated (ECI) autograft

Kamal, Achmad Fauzi; Ismail, Ismail; Miraj, Faisal; Hutagalung, Errol Untung

doi:10.13181/mji.v20i2.441

Cited by 7 publications

(10 citation statements)

References 18 publications

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“…Our previous study ECI demonstrated a good MSTS score (70.63%) with 20% infection rate. Local recurrence also reported as high as 20% [7]. Sharma et al [31] reported an infection rate of 14%.…”

Section: Discussionmentioning

confidence: 99%

“…These advancements in bone tumor management have given both surgeons and patients more options for treatment, other than mere limb ablation. Currently, 90–95% of patients with sarcoma of the extremities that were administered in tertiary referral centre can undergo musculoskeletal LSS with a successful result [[5], [6], [7], [8], [9]].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, we are able to choose from a variety of methods of reconstruction, including os-teoarticular allografts/autografts, intercalary allografts/autografts, autograft/allograft-prosthetic composites, arthrodesis with autogenous or allogenic bone, custom-made prostheses, and rotationalplasty [7,[11], [12], [13], [14]]. In this study, we analyzed the outcome and survival rate of osteosarcoma patients that underwent LSS by using megaprosthesis, extracorporeally irradiated (ECI) autograft, and modified arthrodesis of the knee with metallic plus bone cement (MAMC) in our hospital, in Jakarta, Indonesia.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical outcome of various limb salvage surgeries in osteosarcoma around knee: Megaprosthesis, extracorporeal irradiation and resection arthrodesis

Kamal

Rubiansyah

2019

Annals of Medicine and Surgery

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Background We evaluated the outcome and the survival rate of Limb salvage surgeries (LSSs) in osteosarcoma around knee by using megaprosthesis, ECI autograft, and modified arthrodesis of the knee with metallic plus bone cement (MAMC). Methods We reviewed 35 cases of osteosarcoma around the knee that was treated by megaprosthesis, ECI autograft and MAMC from 2012 to 2017. The survival, local recurrence, metastases, complications and functional MSTS score were evaluated for each operation technique. Kaplan-Meier was used to describe the survival rate for each technique. Result Megaprostheses group had an excellent MSTS score (78.7%), the ECI group (72.3%) and MAMC group (68.4%). Local recurrence occurred in the megaprothesis group (0%), the ECI group (9.1%) and MAMC group (20%). Infection occurred in 3 cases of ECI (13.6%) while only 2 (40%) cases in MAMC group and 1 case (12.5%) in the megaprostheses group. Aseptic loosening occurred in the megaprostheses group 1 case (12.5%) and MAMC 1 case (20%). Metastases occurred in 18.2% of the ECI group compared to 25% of the megaprostheses group and 40% of the MAMC group. The megaprosthesis group had an overall survival rate of 90.9 months, whilst the ECI group is on 94.6 months and the MAMC group was 47.2 months. Conclusion Megaprosthesis showed good-excellent functional outcome and survival rate. ECI that is an option in LSS has good functional outcome as well. Knee arthrodesis with MAMC it is still an option to perform LSS even in the advanced local stage of the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical outcome of various limb salvage surgeries in osteosarcoma around knee: Megaprosthesis, extracorporeal irradiation and resection arthrodesis

Kamal

Rubiansyah

2019

Annals of Medicine and Surgery

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“…Parosteal osteosarcoma is a relatively rare bone tumour. It is reported that, in our national referral hospital, the incidence of osteosarcoma was 16.8 cases per year [4]. From this series, we identified six patients with parosteal osteosarcoma over a period of twenty years.…”

Section: Discussionmentioning

confidence: 99%

Parosteal Osteosarcoma: A Benign-Looking Tumour, Amenable to a Variety of Surgical Reconstruction

Prabowo

Kamal

Kodrat

et al. 2020

International Journal of Surgical Oncology

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Osteosarcoma arising from cortical surface is classified into parosteal, periosteal and high-grade surface osteosarcoma. Along the spectrum, parosteal osteosarcoma occupies the well-differentiated end. It is a relatively rare disease entity, comprised only 4% of all osteosarcomas and barely reported in the literature. The objective of this study is to describe cases of parosteal osteosarcoma as well as a variety of treatment options amenable to such entity. Six cases of parosteal osteosarcoma were identified based on histopathological reports in a tertiary referral hospital in Jakarta, Indonesia between January 2001 and December 2019. The mean age was 29.8 years old; four of them (66.7%) were male. Distal end of femur was the most commonly involved bone (five cases, 83.3%). The patients were treated with wide excision followed by several different reconstruction methods: replacement with endoprosthesis, extracorporeal irradiation, knee arthrodesis, or prophylactic fixation. One of our patients presented with dedifferentiated component, and therefore was treated by limb ablation. While two cases died of pulmonary metastasis, other patients reported fair to excellent functional outcome.

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“…Osteosarcoma is known to have a bimodal age distribution with first peaked in young adults and the second in the elderly [2, 4 -7]. Within a period of 13 years (1995-2007), there were 219 cases (16.8/year) at Cipto Mangunkusumo General Hospital, Jakarta with the largest distribution in the second decade [8].…”

Section: Introductionmentioning

confidence: 99%

Isolation, Culture and Characterization of Cancer Stem Cells from Primary Osteosarcoma

Kamal¹,

Pranatha²,

Sugito³

et al. 2018

TOSCJ

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Background:Osteosarcoma cancer stem cells (CSCs) are defined as a subpopulation of osteosarcoma cells, which have the ability of self-renewal, proliferation and differentiation. This study aimed to identify CSCs from human osteosarcomain vitro.Methods:Osteosarcoma CSCs were isolated and cultured with sphere-forming assay technique on an ultra-low well attachment surface plate. After sarcosphere colonies were formed, we conducted reverse transcriptase-polymerase chain reaction (RT-PCR) to detect the expression of genes of embryonic stem cells such asNANOG, Oct3/4, STAT3 and gene of MSC CD133. Immunofluorescence analysis (IFA) of alkaline phosphatase (ALP), osteocalcin, and CD 133 was also performed to see the expression of osteosarcoma CSC surface protein with immuno-enzymatic staining principle. We also performed alizarin red staining to evaluate calcification in osteosarcoma CSCs.Results:The culture sphere-of the osteosarcoma cells showed three dimension round shaped colonies (sarcospheres) in slightly hypoxicand serum free condition which was not attached to the substrate with tight density. RT-PCR demonstrated that sarcospheres expressed genes which encodeNANOG, Oct3/4 STAT 3, but not for CD 133. IFA showed positive protein expression of ALP, osteocalcin and CD 133 which was moderate, strong, and weak positive respectively. Sarcospheres also had a positive reaction toward alizarin red staining.Conclusion:Osteosarcoma CSCs could be isolated from human osteosarcoma by sphere-forming assay technique and characterized by the expression of genes of embryonic stem cells,such asNANOG, Oct3/4, STAT3 and IFA of ALP, osteocalcin, and CD 133.

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Outcomes of stage IIB osteosarcoma treated by limb salvage surgery using extracorporeally irradiated (ECI) autograft

Cited by 7 publications

References 18 publications

Clinical outcome of various limb salvage surgeries in osteosarcoma around knee: Megaprosthesis, extracorporeal irradiation and resection arthrodesis

Clinical outcome of various limb salvage surgeries in osteosarcoma around knee: Megaprosthesis, extracorporeal irradiation and resection arthrodesis

Parosteal Osteosarcoma: A Benign-Looking Tumour, Amenable to a Variety of Surgical Reconstruction

Isolation, Culture and Characterization of Cancer Stem Cells from Primary Osteosarcoma

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