Clinical outcome of various limb salvage surgeries in osteosarcoma around knee: Megaprosthesis, extracorporeal irradiation and resection arthrodesis

Kamal, Achmad Fauzi; Rubiansyah, Primadika

doi:10.1016/j.amsu.2019.04.005

Cited by 22 publications

(19 citation statements)

References 31 publications

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“…Consistent with the results of previous studies, histologically, the common types of osteosarcomas seen were conventional, fibroblastic, and chondroblastic, 13 and the most common stage was the Enneking stage 2B. 5,15 Recent studies have shown that the 5-year survival rate for primary osteosarcomas is approximately 65%-70%, 16,17 although a survival rate of approximately 90% has also been reported. 18 Recent advances in chemotherapy and surgical treatments for osteosarcoma have improved the survival rates compared to those in the 1970s.…”

Section: Discussionsupporting

confidence: 84%

Outcomes of comprehensive treatment for primary osteosarcoma

et al. 2020

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Purpose: This study aimed to evaluate the clinical features and outcomes of osteosarcoma to identify prognostic factors and determine new strategies to improve overall survival. Patients and Methods: We retrospectively analyzed 12 cases of osteosarcoma treated at our hospital from 2012 to 2017. Tumor site, tissue type, stage, treatments, adverse effects, postoperative limb function, surgical margin, and final outcomes were evaluated. Results: All patients received chemotherapy, and 10 underwent wide resection. The Musculoskeletal Tumor Society scores were more than good in all cases, and the 3-year survival rate was 73.3%. Two patients are alive with disease, eight have remained disease-free, and two died of the disease. Three of the four recurrent cases involved the pelvis. Conclusion: The treatment of primary osteosarcoma with wide resection in our department, therefore, yielded favorable outcomes. However, improved treatment strategies are needed for pelvic and advanced cases.

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Section: Discussionsupporting

confidence: 84%

Outcomes of comprehensive treatment for primary osteosarcoma

et al. 2020

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“…4) could be the alternative methods of surgical reconstruction. Both methods have been found to result in a reasonable functional outcome even in later stages of the disease [12].…”

Section: Discussionmentioning

confidence: 99%

Parosteal Osteosarcoma: A Benign-Looking Tumour, Amenable to a Variety of Surgical Reconstruction

Prabowo

Kamal

Kodrat

et al. 2020

International Journal of Surgical Oncology

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Osteosarcoma arising from cortical surface is classified into parosteal, periosteal and high-grade surface osteosarcoma. Along the spectrum, parosteal osteosarcoma occupies the well-differentiated end. It is a relatively rare disease entity, comprised only 4% of all osteosarcomas and barely reported in the literature. The objective of this study is to describe cases of parosteal osteosarcoma as well as a variety of treatment options amenable to such entity. Six cases of parosteal osteosarcoma were identified based on histopathological reports in a tertiary referral hospital in Jakarta, Indonesia between January 2001 and December 2019. The mean age was 29.8 years old; four of them (66.7%) were male. Distal end of femur was the most commonly involved bone (five cases, 83.3%). The patients were treated with wide excision followed by several different reconstruction methods: replacement with endoprosthesis, extracorporeal irradiation, knee arthrodesis, or prophylactic fixation. One of our patients presented with dedifferentiated component, and therefore was treated by limb ablation. While two cases died of pulmonary metastasis, other patients reported fair to excellent functional outcome.

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“…JPS also has the advantage of being able to better protect the epiphyseal plate in certain pediatric OS patients [56], and thereby avoid the risk of causing a limb length discrepancy. These data, although also showing that extracorporeal irradiation is associated with lower functional outcomes and higher recurrence rates, may set the ground for JPS becoming the mainstream surgery in the future, with the refinement of existing surgical technologies [54,57].…”

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confidence: 90%

Pediatric Osteosarcoma: Connecting Present and Future Approaches to Diagnosis and Treatment

Kapetanos¹,

Asimakopoulos²,

Savvides

et al. 2020

BJSTR

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Pediatric osteosarcoma is a highly aggressive type of cancer, affecting children of all ages. Early diagnosis is key to ensure better outcomes, as pre-metastatic lesions are easier to manage. For this reason, novel screening techniques, such as miRNA biomarkers, have been developed to complement the standard radiological approach to diagnosis. Furthermore, the standard of care in chemotherapeutic treatment is constantly revised, and new drugs are designed to minimize the toxic effects of the treatment whilst maintaining, or even improving, its efficacy. Immunotherapy and radiotherapy are two more disciplines which have demonstrated great promise in their capacity to exert strong anti-tumor properties in a clinical setting. Immunotherapeutic drugs like Mifamurtide, and radiological treatments such as proton beam therapy are starting to form an essential part of the golden standard of care. Lastly, innovations in orthopedic oncology provide surgical techniques with the potential to improve surgical outcomes whilst preserving as much of the patient's healthy tissue as possible. This review appreciates that there is a great promise held in the future of osteosarcoma treatment, and highlights where attention should be paid in the future.

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Clinical outcome of various limb salvage surgeries in osteosarcoma around knee: Megaprosthesis, extracorporeal irradiation and resection arthrodesis

Cited by 22 publications

References 31 publications

Outcomes of comprehensive treatment for primary osteosarcoma

Outcomes of comprehensive treatment for primary osteosarcoma

Parosteal Osteosarcoma: A Benign-Looking Tumour, Amenable to a Variety of Surgical Reconstruction

Pediatric Osteosarcoma: Connecting Present and Future Approaches to Diagnosis and Treatment

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