Outcomes of squamous histology in bladder cancer: A population-based study

Izard, Jason; Siemens, D. Robert; Mackillop, William J.; Wei, Xuejiao; Leveridge, Michael; Berman, David M.; Peng, Yingwei; Booth, Christopher M.

doi:10.1016/j.urolonc.2015.06.011

Cited by 50 publications

(49 citation statements)

References 14 publications

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“…Divergent differentiation was the only risk factor related to both cancer recurrence and disease progression. Previous reports have shown that bladder cancer with divergent differentiation was associated with a worse prognosis than pure UC (13)(14)(15)(16)(17)(18)(19), whereas there are conflicting reports about the impact of divergent differentiation on clinical outcomes (25)(26)(27). Xylinas et al (15) reported that divergent differentiation was significantly associated with recurrence and worse CSS in their univariate analysis.…”

Section: Discussionmentioning

confidence: 98%

“…Divergent differentiation implies heterogeneous pathological populations such as glandular differentiation, squamous differentiation or small cell carcinoma in combination with varying percentages of pure UC. The prognostic impact of a divergent differentiation tumor component is controversial (13)(14)(15)(16)(17)(18)(19)(25)(26)(27). Interestingly, the efficacy of BCG therapy is likely to depend on the variant type of bladder cancer in a given patient.…”

Section: Discussionmentioning

confidence: 99%

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Impact of divergent differentiation in urothelial carcinoma on oncological outcome in patients with T1 high-grade bladder cancer

Fujii

Hoshii

Hirata

et al. 2017

Japanese Journal of Clinical Oncology

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Objective: T1 high-grade bladder cancer has a poor prognosis compared with other non-muscleinvasive bladder cancers. We investigated the clinical outcomes among patients with T1 highgrade bladder cancer to identify factors related to cancer recurrence and disease progression. Methods: We retrospectively reviewed the data of 148 patients who were diagnosed with T1 highgrade bladder cancer by transurethral resection from January 2001 to February 2015 at our institution. Clinicopathological factors were analyzed using univariate and multivariate analyses. Results: The median age and follow-up duration were 72 years and 45.4 months, respectively. Sixty-two patients (41.9%) had recurrence, 28 (18.9%) experienced progression and 13 (8.8%) died of bladder cancer. In the multivariate analysis, divergent differentiation was an independent factor related to recurrence (P = 0.0096, hazard ratio = 2.5), whereas a non-papillary tumor shape, divergent differentiation and presence of a residual tumor at the time of the second transurethral resection were independent factors related to progression (P = 0.0349, hazard ratio = 3.8; P = 0.0074, hazard ratio = 6.8 and P = 0.0449, hazard ratio = 4.1, respectively). There were no independent factors related to cancer-specific mortality. Divergent differentiation was the only independent factor associated with both recurrence and progression. In addition, patients with divergent differentiation had significantly worse recurrence-free survival and progression-free survival rates than did patients without divergent differentiation (log-rank P = 0.0009 and P = 0.0019, respectively). Conclusions: In this study, the presence of divergent differentiation was related to worse oncological outcomes in patients with T1 high-grade bladder cancer. Patients with divergent differentiation may require stringent follow-up and early cystectomy after recurrence to improve oncological outcomes.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Impact of divergent differentiation in urothelial carcinoma on oncological outcome in patients with T1 high-grade bladder cancer

Fujii

Hoshii

Hirata

et al. 2017

Japanese Journal of Clinical Oncology

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“…Although squamous features are present in Urothelial carcinoma variants with mixed histology, the definition of SCC or pure SCC is reserved for tumors that only contain squamous components without any evidence of urothelial components. [13] In this case inspite of repeated processing and sectioning no evidence of Urothelial carcinoma was found.…”

Section: Discussionmentioning

confidence: 62%

Urinary Bladder Cancer : Two Rare Cases

Gupta

Barui

Das

2017

APALM

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Urinary bladder carcinoma is the seventh most common carcinoma worldwide. Most common type is urothelial carcinoma. Rest of the types are squamous cell carcinoma, Adenocarcinoma, small cell carcinoma, sarcoma. Here we present two rare cases of urinary bladder carcinoma one 72 yr. male diagnosed as Adenocarcinoma and another 55 yr. female diagnosed as Squamous cell carcinoma, both presented with features of hematuria and irritating symptoms of bladder.

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“…Factors affecting survival in NUBCs are stage [8-10, 12, 17, 20, 21, 23], LNI [8-10, 21, 22], grade [8,10,21,23], advanced age [9], positive margins [9], non-SqCC [18] histology, and locoregional recurrence [26]. Our multivariate analysis showed that factors affecting OS were advanced age, stage IV disease, and poor ECOG performance status.…”

Section: Discussionmentioning

confidence: 86%

“…The 5-year survival rates of the patients who underwent radical cystectomy were 25.1-57.0% and 13.0-35.0% for SqCC [9,18,22,23] and AC [2,17,18,24], respectively. In our study, these rates were 42% and 25%, respectively, in accordance with the literature.…”

Section: Discussionmentioning

confidence: 98%

Non-Urothelial Bladder Cancer: Comparison of Clinicopathological and Prognostic Characteristics in Pure Adenocarcinoma and Non-Bilharzial Squamous Cell Carcinoma of the Bladder

et al. 2018

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Objectives: The clinicopathological characteristics, treatment modalities, and effects on the prognosis of pure squamous cell carcinoma (SqCC) and adenocarcinoma (AC) were evaluated. Materials and Methods: 86 patients with pure SqCC and AC bladder cancer were evaluated retrospectively. Results: Of the 86 patients, 51 had SqCC and 35 had AC. No differences in clinicopathological characteristics were observed between patients with AC and SqCC, except for the prevalence of T4 disease (28.6% vs. 51.0%, respectively). In multivariate analysis, older age, stage IV disease, and Eastern Cooperative Oncology Group (ECOG) performance status (> 2) were predictive of a poor overall survival (OS). The median OS was significantly longer for stage I-III patients (82.9 months) treated with surgery ± chemotherapy (CT) ± radiotherapy (RT) than for those treated with transurethral resection ± CT ± RT (24.3 months) (P = 0.007). The median OS of patients with SqCC and AC who were given platinum-based CT for metastasis was 7.7 and 30.3 months, respectively. Conclusions: Advanced age, stage IV disease, and poor ECOG performance status were factors associated with a poor prognosis. Surgery ± CT ± RT resulted in significantly better OS, except in stage IV disease. Patients with metastatic AC had better response rates with platinum-based CT.

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Outcomes of squamous histology in bladder cancer: A population-based study

Cited by 50 publications

References 14 publications

Impact of divergent differentiation in urothelial carcinoma on oncological outcome in patients with T1 high-grade bladder cancer

Impact of divergent differentiation in urothelial carcinoma on oncological outcome in patients with T1 high-grade bladder cancer

Urinary Bladder Cancer : Two Rare Cases

Non-Urothelial Bladder Cancer: Comparison of Clinicopathological and Prognostic Characteristics in Pure Adenocarcinoma and Non-Bilharzial Squamous Cell Carcinoma of the Bladder

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