Non-Urothelial Bladder Cancer: Comparison of Clinicopathological and Prognostic Characteristics in Pure Adenocarcinoma and Non-Bilharzial Squamous Cell Carcinoma of the Bladder

Abstract

Objectives: The clinicopathological characteristics, treatment modalities, and effects on the prognosis of pure squamous cell carcinoma (SqCC) and adenocarcinoma (AC) were evaluated. Materials and Methods: 86 patients with pure SqCC and AC bladder cancer were evaluated retrospectively. Results: Of the 86 patients, 51 had SqCC and 35 had AC. No differences in clinicopathological characteristics were observed between patients with AC and SqCC, except for the prevalence of T4 disease (28.6% vs. 51.0%, respectively). In multivariate analysis, older age, stage IV disease, and Eastern Cooperative Oncology Group (ECOG) performance status (> 2) were predictive of a poor overall survival (OS). The median OS was significantly longer for stage I-III patients (82.9 months) treated with surgery ± chemotherapy (CT) ± radiotherapy (RT) than for those treated with transurethral resection ± CT ± RT (24.3 months) (P = 0.007). The median OS of patients with SqCC and AC who were given platinum-based CT for metastasis was 7.7 and 30.3 months, respectively. Conclusions: Advanced age, stage IV disease, and poor ECOG performance status were factors associated with a poor prognosis. Surgery ± CT ± RT resulted in significantly better OS, except in stage IV disease. Patients with metastatic AC had better response rates with platinum-based CT.

Partial cystectomy for bladder squamous cell carcinoma with a 10-year follow-up: a case report

“…The patient was found to have an occupying bladder lesion on physical examination and was admitted with only mild urinary frequency and no meatus hematuria. On the other hand, SCC patients with T3/4 disease usually exhibit a lower rate of lymph node metastases (10%–25%) and distant metastases (8%–27.7%) ( 20 ). This case is consistent with the report of ERDEM, which showed no lymph node invasion and pelvic metastasis on CT 10 years ago.…”

Incidence rate, basic characteristics, and survival outcomes of bladder squamous cell carcinoma

“…Furthermore, in patients with BSCC, neoadjuvant chemotherapy prior to radical cystectomy did not confer a survival benefit. Previous studies 8,[10][11][12] found that BSCC patients were less sensitive to chemotherapy and more prone to chemotherapy resistance when compared with UC patients. This may also explain that the proportion of receiving chemotherapy in BSCC patients is lower than that in UC patients.…”