A mixture of ketamine, midazolam and atropine given orally provides sedation and analgesia similar to that produced by the same drugs given intramuscularly. It offers advantage over the intramuscular route as it is painless and can be given for minor paediatric oncology procedures with appropriate monitoring.

Background:The spectrum of skin cancer in Kashmir valley is drastically different from the rest of the country. Maxwell was the first to report skin cancer of lower extremities in Kashmiri population, developing on/over erythema ab igne, and attributed it to the use/or exposure of Kangri. These tumors have an aggressive biological behavior with a substantial risk of loco-regional metastasis in 30-50% cases. Because of unique geographical distribution of Kangri cancer, there is dearth of literature regarding the natural history, loco-regional and distant metastatic pattern and treatment recommendations in these tumors.Aims:To study the metastatic pattern of these skin tumors and to assess the impact of various treatment modalities and use of prophylactic nodal treatment in this clinical entity.Methods:The retrospective study (study period 1993-2005) included 266 patients of squamous cell carcinoma of skin of lower extremities and abdominal wall. Two hundred and forty-four cases with a follow-up of 2-7 years were included for final analysis with stress on loco-regional relapse pattern and methods of treatment evolved and used at our institute from time to time. Statistical analysis was done using yates corrected Chi-square test and odds ratio analysis.Results:Our results favor the use of post operative radiotherapy to primary and prophylactic treatment of regional nodes on the lines of head and neck tumors in these cases.Conclusion:Post operative radiotherapy significantly decreases the loco-regional recurrences and a trial of prophylactic nodal irradiation is justified in a selected group of such patients.

Context:Pain is the most common symptom in admitted cancer patients. The association between the severity of cancer pain and distress symptoms such as depression and anxiety is a subject of research.Aims:The aim is to study the prevalence of pain, anxiety, and depression in admitted cancer patients and determine the association between pain and anxiety and depression at a tertiary cancer care institute.Settings and Design:This was prospective observational study.Subjects and Methods:We enrolled 393 cancer inpatients prospectively after written informed consent. Their disease details, presence, severity, and character of pain were recorded. Numerical Pain Scale was used for pain scores, self-reporting Hospital Anxiety and Depression Scale for anxiety and depression.Statistical Analysis Used:Normal data were analyzed with parametric, nonnormal with nonparametric methods, and categorical with the Chi-square test.Results:The prevalence of moderate-to-severe pain was 41.5%, anxiety 20.3%, and depression 24.8%. Proportion of patients with anxiety and depression was 9.2% and 17.7% in patients with no pain; about 32.8% and 36.7% with severe pain, respectively (P < 0.000). In patients with no depression 6% had anxiety; with depression 44.9% had anxiety (P < 0.000). Odd's ratio to have anxiety and depression was 4.44 (95% confidence interval [CI] 2.0318–9.7024) and 2.92 (95% CI 1.5739–5.4186), respectively, in patients with pain as compared to no pain (P < 0.00). There was a positive correlation between pain, anxiety, and depression scores.Conclusions:There is strong association between the presence and severity of pain and distress symptoms such as anxiety and depression in admitted cancer patients.

Background and Objective:The study was carried out to find the profile of pediatric brain and spinal cord tumors during 2006–2015 in a tertiary referral center of North India.Materials and Methods:It was a retrospective medical record-based observational study. All children <18 years of age with confirmed histopathological diagnosis of cancer were included in the study.Results:Central nervous system (CNS) tumors constituted 5.6% of all pediatric solid malignancies in our hospital. A total of 54 brain tumors and 13 spinal cord tumors were studied. Medulloblastoma was the most common brain tumor (20.3%) followed by pilocytic astrocytoma (16.6%) and glioblastoma multiforme (9.2%). The most common spinal cord tumor was Ewing's sarcoma/primitive neuroectodermal tumor (30.7%) followed by ependymoma (23%). Mean age was 10.5 years and 12.1 years for brain and spinal cord tumors, respectively. There was male predominance in brain tumors while the sex ratio was almost equal in spinal cord tumors. Histomorphologically, necrosis and angiogenesis were associated with higher grades of tumor. Approximately 35% children were alive after a mean follow-up of 36 ± 6 months.Conclusion:Compared with most international studies, we found a higher percentage of medulloblastoma in the brain, thus stressing the role of regional and ethnic influences in the pathogenesis of CNS tumors.

Tracheal bronchus is a rare congenital anomaly (incidence ranging from 0.1% to 2%) of bronchial tree in which an aberrant bronchus originates in trachea anywhere above carina, but usually within 2 cm of carina. Cancer within the bronchial anomaly is further uncommon. A subtype of tracheal bronchus, known as "true tracheal bronchus" or "pig bronchus" is a condition in which right upper lobe (RUL) bronchus is absent and the RUL is ventilated by the aberrant tracheal bronchus. We present a case of true tracheal bronchus with malignancy of the affected RUL. To the best of our knowledge, in world literature, this is the second case of true tracheal bronchus affected by lung cancer.

curcumin is an important bioactive component of turmeric and also one of the important natural products, which has been investigated extensively. The precise mode of action of curcumin and its impact on system level protein networks are still not well studied. To identify the curcumin governed regulatory action on protein interaction network (PIN), an interectome was created based on 788 key proteins, extracted from PubMed literatures, and constructed by using STRING and Cytoscape programs. The PIN rewired by curcumin was a scale-free, extremely linked biological system. MCODE plug-in was used for sub-modulization analysis, wherein we identified 25 modules; ClueGo plug-in was used for the pathway's enrichment analysis, wherein 37 enriched signalling pathways were obtained. Most of them were associated with human diseases groups, particularly carcinogenesis, inflammation, and infectious diseases. Finally, the analysis of topological characteristic like bottleneck, degree, GO term/pathways analysis, bio-kinetics simulation, molecular docking, and dynamics studies were performed for the selection of key regulatory proteins of curcumin-rewired PIN. The current findings deduce a precise molecular mechanism that curcumin might exert in the system. This comprehensive in-silico study will help to understand how curcumin induces its anti-cancerous, anti-inflammatory, and anti-microbial effects in the human body. Naturally derived compounds possess enormous potential for medicinal and therapeutic actions for the management of diseases and curcumin is one of the most suitable examples among them. Curcumin is a yellowish-orange polyphenolic compound of turmeric/haldi (Curcuma longa), a herb often found in curry powder. The reason for the selection of curcumin for this study is, it is one of the important and thoroughly investigated naturally occurring bioactive compound, but its precise mode of action is still unclear. The global curcumin market was valued at $58.4 million in 2019 and is projected to reach $104.19 million by 2025. (https ://www.allie dmark etres earch .com/press-relea se/curcu min-marke t.html & https ://www.grand viewr esear ch.com/indus try-analy sis/ turme ric-extra ct-curcu min-marke t). Earlier studies clearly exhibit the highly pleiotropic actions of curcumin as anti-cancerous 1,2 , anti-inflammatory 2,3 , anti-microbial 4 , anti-oxidant 5 , cardio-protective 6 , radio-protective 7 and many more that makes it an ideal ingredient in different medical and food applications. Curcumin's market is expected to witness a huge development due to growth in consumer awareness regarding its therapeutic properties, and that's why an intense scientific study are urgently needed to explore the precise mechanistic action of curcumin. Many research studies have been published in the past dealing with the mode of action of curcumin yet inconclusive, and still the puzzle remains unsolved. This pleiotropic potential of curcumin can be endorsed to its capability to interact with a huge interactome of biomolecular targets ...

Cross-cultural adaptation of self-reported measures to other languages endeavors to enhance the validity and reliability of the instrument for the local population. Traditionally, qualified academicians or language experts performed the translation task, but nowadays, various online translation tools are available for the same. The present study intends to compare the validity of traditional and online modes of translation of selfreported measures, and to develop a hybrid method by combining the traditional and online methods to achieve an accurate translation cost-effectively. For this purpose, the existing English version of shame and stigma scale was translated into the Hindi language traditionally by language experts, Google translator, and by a hybrid method. The validity of translated versions was tested using the content validity index (CVI). The CVI score was found to be 0.94 for the traditional method, which is significantly higher compared to the online translation method in which the CVI score was 0.42. CVI score in the hybrid method comes to be 0.84. The present study suggests that the online translation method alone is insufficient for the accurate translation of questionnaires and, therefore, it is recommended that hybrid method should be followed for the process of cross-cultural adaptation of self-report measures to impart high accuracy in a cost-effective manner.

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