Profile of primary pediatric brain and spinal cord tumors from North India

Shirazi, Nadia; Gupta, Meenu; Bhat, Nowneet Kumar; Kalra, Braham Prakash; Kumar, Rajneesh; Saini, Manju

doi:10.4103/0971-5851.203514

Cited by 12 publications

(14 citation statements)

References 15 publications

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“…Regarding the location of brain tumors, a frequency of posterior fossa tumors was found in 22.4%, which is similar to that reported by Ostrom et al 7 , whose five most frequent locations were: cerebellum, with 18.5%; other brain regions, with 15.2%; brainstem, with 12.4%, followed by pituitary and craniopharyngeal duct (8.1%) and cranial nerve tumors (7.5%). As regards histological variants, Azad et al 14 reported that the most common was ependymoma, with 19.4%, followed by pilocytic astrocytoma and medulloblastoma with 16.7% each, while, in our findings, the most common was medulloblastoma with 22.4%, followed by pilocytic astrocytoma and neuroectodermal tumor with 16.5% and 8.2%, respectively; similarly, Shirazi et al 19 found medulloblastoma (n = 11, 20.37%) to be the most common neoplasm. In turn, Zhou et al 20 , in their study carried out in China with 1,485 cases, found astrocytoma (31%), craniopharyngioma (18%), medulloblastoma (15%), germ cell tumors (8%) and ependymal tumors (6%) to be the most common CNS tumors.…”

Section: Discussionsupporting

confidence: 84%

Características clínicas y epidemiológicas de niños con tumores del sistema nervioso central en Medellín, Colombia

Orozco-Forero¹,

Martínez-Sánchez²,

Pamplona-Sierra³

et al. 2020

GAMO

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Introduction: To determine the clinical and epidemiological profile of the pediatric population diagnosed with central nervous system (CNS) tumors treated in a third-level care institution in Medellin, Colombia, between 2010 and 2015. Methods: Observational, descriptive and retrospective study, which includes the information from clinical records of pediatric patients between 0 and 14 years of age with clinical diagnosis and/or imaging of CNS tumors. The analysis was carried out with the SPSS ® program. Results: 85 children with CNS tumors were included; the average age of diagnosis was 5.7 years. The main clinical findings were headache 41.2%, and nausea and/or vomiting 29.4%. 74.1% of the tumors were of primary origin and only 8.2% was secondary to metastasis; the main location was posterior fossa with 22.4%. Conclusion: Despite the fact that the results of this study coincide with what has been described in the literature, it was possible to demonstrate that epidemiological studies with a larger sample are needed, which would make possible to evaluate other variables that allow the characterization of neoplasms of the nervous system in the pediatric population.

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Section: Discussionsupporting

confidence: 84%

Características clínicas y epidemiológicas de niños con tumores del sistema nervioso central en Medellín, Colombia

Orozco-Forero¹,

Martínez-Sánchez²,

Pamplona-Sierra³

et al. 2020

GAMO

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“…[ 1 2 3 ] There are not many studies from India which have looked into the epidemiology of pediatric brain tumors and compared it with data from the rest of the world. [ 4 5 6 7 8 9 10 11 12 ] Since this is a hospital-based study, it may not reflect the true epidemiology of the tumors, but nevertheless, it is the first attempt of its kind from Kerala. The aim of this study was to analyze the epidemiology of pediatric brain tumors in North Kerala and compare it with data from the rest of India and other countries.…”

Section: Introductionmentioning

confidence: 99%

Pediatric intracranial tumors over a 5-year period in a tertiary care center of North Kerala, India: A retrospective analysis

Govindan¹,

Parambil²,

Alapatt³

2018

Asian J Neurosurg

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Background:Pediatric brain tumors are unique in terms of distribution, clinical presentation, pathologic types, management, and prognosis. There are not many studies from India which have looked into the epidemiology of pediatric brain tumors.Aims:This study aimed to analyze the epidemiology of pediatric brain tumors in North Kerala and compare it with data from the rest of India and other countries.Materials and Methods:This is a retrospective study of 5-year data of pediatric brain tumors which were operated in a tertiary referral center in North Kerala, India, from 2009 to 2013. The data were procured from the departments of neurosurgery and pathology of the institution. The data were tabulated and analyzed using SPSS software.Results:A total of 71 children had histologically proven brain tumors during the 5-year period. There were 34 boys and 37 girls. Distribution in different age groups was as follows: infancy –5 (7%), 1–5 years –22 (31%), 6–10 years – 21 (29.6%), and 11–18 years – 23 (32.4%). The most common tumors were primitive neuroectodermal tumors (PNETs). In infancy, the number of high-grade tumors was more, whereas in the 11–18 years’ age group, there were a significantly higher number of low-grade tumors (P = 0.04).Discussion:Pediatric brain tumors were distributed almost equally in both sexes. PNET was the most common. We could not get statistical significance in many of our values due to small sample size.Conclusion:This study highlights the need for diligent collection of data and maintenance of a registry for brain tumors to study the disease in the Indian population.

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“…Central nervous system tumors are the most common solid tumors and the most important cause of cancer death in pediatric patients [9]. Low-grade and high-grade astrocytomas are one of the most common primary pediatric brain tumors [10]. Although pediatric brain tumors differ from adult tumor, the same treatment protocol is applied.…”

Section: Discussionmentioning

confidence: 99%

NEAT1 Is a Novel Oncogenic LncRNA and Correlated with miR-143 in Pediatric Oligodendrogliomas

Aksoy¹,

Mutlu²,

Balcin³

et al. 2021

Pediatr Neurosurg

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Introduction: The noncoding RNAs (ncRNAs) play a role in biological processes of various cancers including gliomas. The majority of these transcripts are uniquely expressed in differentiated tissues or specific glioma types. Pediatric oligodendroglioma (POG) is a rare subtype of diffuse glioma and accounts for <1% of pediatric brain tumors. Because histologically POG resembles adult OG, the same treatment is applied as adults. However, the significance in predicting outcomes in POG patients is unclear. In this study, we aimed to investigate the prognostic significance of expression profiles of microRNA (miRNA) and long noncoding RNA (LncRNA) in POGs. Methods: We investigated the levels of 13 known miRNAs and 6 LncRNAs in tumor samples from 9 patients with primary POG by using RT-PCR and analyzed their association with outcomes. Results: The expression levels of miR-21, miR-106a, miR-10b, and LncRNA NEAT1 were higher, and the expression level of miR-143 was lower in POG tissues compared with normal brain tissues (p = 0.006, p = 0.032, p = 0.034, p = 0.002, and p = 0.001, respectively). High levels of NEAT1 and low expression of miR-143 were associated with decreased probability of short disease-free survival (p = 0.018 and p = 0.022, respectively). Discussion: NEAT1 and miR-143 levels could serve as reciprocal prognostic predictors of disease progression in patients with POG. New treatment models to regulate the expression levels of NEAT1 and miR-143 will bring a new approach to the therapy of POG.

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Profile of primary pediatric brain and spinal cord tumors from North India

Cited by 12 publications

References 15 publications

Características clínicas y epidemiológicas de niños con tumores del sistema nervioso central en Medellín, Colombia

Características clínicas y epidemiológicas de niños con tumores del sistema nervioso central en Medellín, Colombia

Pediatric intracranial tumors over a 5-year period in a tertiary care center of North Kerala, India: A retrospective analysis

NEAT1 Is a Novel Oncogenic LncRNA and Correlated with miR-143 in Pediatric Oligodendrogliomas

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