Outcomes of orthotopic liver transplantation in Chile

Pediatric liver transplantation: 10 years of experience at a single center in Brazil

“…Assim como relatado na maioria dos centros de transplante pediátrico, à exceção da Turquia, onde as principais causas são doenças metabólicas, a atresia de vias biliares foi a indicação mais freqüente nesta casuística 8,[13][14][15][16][17] . O fato de o segundo diagnóstico mais freqüente no grupo transplantado ser a hepatite fulminante está relacionado à prioridade que estes pacientes alcançam, conseguindo doações que provavelmente iriam para receptores adultos, sendo também a segunda indicação em outros estudos 14,16,17 .…”

Transplante hepático pediátrico: experiência de 10 anos em um único centro no Brasil

“…8,13,[18][19][20][21][22] Primary non-function and thrombosis of the hepatic artery were the principal causes of death of patients transplanted for chronic liver disease, which is a result that differs from other pediatric transplant centers, where infections tend to be the principal cause of death. 3,8,14,18,22,23 This difference can be attributed to the increased frequency of hepatic artery thrombosis found in this sample.…”

“…6,10-12 In common with what is reported by the majority of pediatric transplant centers, with the exception of Turkey where the primary cause is metabolic diseases, biliary atresia was the most common indication in this sample. 8,[13][14][15][16][17] The fact that the second most common diagnosis among the group of transplant recipients was fulminating hepatitis is related to the priority that these patients are given, receiving donor organs that would probably go to adult recipients, and other studies have also listed this as their second most common indication. 14,16,17 For the subset of patients transplanted due to chronic liver disease, the five-year survival rate is within the range of results obtained by leading transplant centers, where survival rates can reach 90% during the first year and 64.3 to 83.3% after 5 years.…”

“…8,[13][14][15][16][17] The fact that the second most common diagnosis among the group of transplant recipients was fulminating hepatitis is related to the priority that these patients are given, receiving donor organs that would probably go to adult recipients, and other studies have also listed this as their second most common indication. 14,16,17 For the subset of patients transplanted due to chronic liver disease, the five-year survival rate is within the range of results obtained by leading transplant centers, where survival rates can reach 90% during the first year and 64.3 to 83.3% after 5 years. 8,13,[18][19][20][21][22] Primary non-function and thrombosis of the hepatic artery were the principal causes of death of patients transplanted for chronic liver disease, which is a result that differs from other pediatric transplant centers, where infections tend to be the principal cause of death.…”

“…19,27 Thrombosis of the hepatic artery is a severe vascular complication that results in loss of the graft and an indication of immediate repeat transplantation. 3,13,14,17,18 It is more common in the pediatric age group (7 to 8%), to a great extent because of technical difficulties, such as the disproportionate diameters of donor and recipient blood vessels, with greater risk of stenosis and thrombosis at the anastomoses. 3 The rate of hepatic artery thrombosis in this patient sample was 16.6%, which is above what is described in the literature.…”