Outcomes after endoscopic ultrasound‐guided ethanol‐lipiodol ablation of small pancreatic neuroendocrine tumors

Choi, Jun‐Ho; Park, Do Hyun; Kim, Myung–Hwan; Hwang, Hyeon-Shik; Hong, Seung‐Mo; Song, Tae Jun; Lee, Sang Soo; Seo, Dong–Wan; Lee, Sung Koo

doi:10.1111/den.13058

Cited by 43 publications

(49 citation statements)

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“…Therefore, considering the adverse events, ≤2.0 mL ethanol per session seems to be better for avoiding adverse events. Choi et al . reported that the presence of a capsule around the tumor was a significant factor influencing the success of complete ablation ( P = 0.008).…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports on treatment with EUS-guided ethanol injection have described the amount of ethanol as ranging from 0.3 to 8.0 mL. [3][4][5][6][7] Park et al 3 reported the outcomes of 11 patients with 14 tumors, and a median 1.6 (range: 0.5-3.8) mL of ethanol per session was used for tumors of a median 12.2 (range 8-19) mm in size. Median total amount of ethanol for each tumor was thus 2.5 (range 0.5-7) mL.…”

Section: Discussionmentioning

confidence: 99%

“…The optimal approach for treating patients with nonfunctional, small (≤2 cm in diameter) pancreatic neuroendocrine tumors (p‐NET) is controversial . Recently, endoscopic ultrasonography (EUS)‐guided ablation has been proposed for the treatment of patients with small p‐NET . Using a pure ethanol or ethanol‐lipiodol emulsion, the complete ablation rate has been reported to be approximately 50% with a single session and up to 60% with an additional session .…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7][8] Using a pure ethanol or ethanol-lipiodol emulsion, the complete ablation rate has been reported to be approximately 50% with a single session and up to 60% with an additional session. 3,4 Mild pancreatitis occurred in a few patients who required injection with a large amount of ethanol in one session. [3][4][5][6][7] When an additional session is scheduled before the first injection, the volume of ethanol can be adjusted to be within the safe range.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and safety of scheduled early endoscopic ultrasonography‐guided ethanol reinjection for patients with pancreatic neuroendocrine tumors: Prospective pilot study

Matsumoto

Kato

Fujiwara

et al. 2019

Digestive Endoscopy

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Endoscopic ultrasonography (EUS)‐guided ethanol injection was recently proposed for treatment of patients with small pancreatic neuroendocrine tumors (p‐NET); however, tips on how to carry out safe and effective procedures are unclear. We launched a pilot study for scheduled early EUS‐guided ethanol reinjection for small p‐NET. Major eligibility criteria were presence of pathologically diagnosed grade (G) 1 or G2, tumor size ≤2 cm and being a poor or rejected candidate for surgery. For the treatment, we used a 25‐gauge needle and pure ethanol. Contrast‐enhanced computed tomography (CE‐CT) was carried out on postoperative day 3, and if enhanced areas of the tumor were still apparent, an additional session was scheduled during the same hospitalization period. Primary endpoint was complete ablation rate at 1 month after treatment, and secondary endpoint was procedure‐related adverse events. A total of five patients were treated. Median size of the tumor was 10 (range: 7–14) mm. Of the five patients, three underwent an additional session. Median volume of ethanol injection per session was 0.8 (range: 0.3–1.0) mL, and the total was 1.0 (0.9–1.8) mL. Complete ablation was achieved in four of the five tumors (80%) with no adverse events. During 1 year of follow up, none of the patients reported any procedure‐related adverse events, and no recurrence of tumor. Scheduled early EUS‐guided ethanol reinjection appears to be safe and effective for treating small p‐NET (UMIN number: 000018834).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy and safety of scheduled early endoscopic ultrasonography‐guided ethanol reinjection for patients with pancreatic neuroendocrine tumors: Prospective pilot study

Matsumoto

Kato

Fujiwara

et al. 2019

Digestive Endoscopy

View full text Add to dashboard Cite

show abstract

“…To date, several case reports and a small case series of EUS‐EA have been reported, showing a success rate of 50–100% if success rate is defined as symptom disappearance in patients with functional PNEN (F‐PNEN) and radiological evidence of complete tumor ablation in patients with NF‐PNEN …”

mentioning

confidence: 99%