Outcome of bloodstream infections among spinal cord injury patients and impact of multidrug-resistant organisms

Saliba, Michael J.; Saadeh, Danielle; Bouchand, Frédérique; Duran, Clara; Clair, Bernard; Lawrence, Christine; Annane, Djillali; Denys, Pierre; Salomon, Jérôme; Bernard, Louis; Dinh, Aurélien

doi:10.1038/sc.2016.176

Cited by 10 publications

(7 citation statements)

References 27 publications

(48 reference statements)

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“…7 Although our sample size was small (n < 30), a closer look at the outcome between ESBL-EC (n = 26) and ESBL-KP (n = 13) did not reveal any statistical difference in terms of mortality rate (7.7% in each arm). Moreover, the mortality rates were similar for other ESBL microorganisms (Enterobacter spp, Morganella spp, and Proteus spp (n =21)),~9.5% (P = .99, data not shown).…”

mentioning

confidence: 75%

Differences in mortality between infections due to extended-spectrum-beta-lactamase–producing Klebsiella pneumoniae and Escherichia coli

Burnham

Kwon

Olsen

et al. 2018

Infect. Control Hosp. Epidemiol.

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mentioning

confidence: 75%

Differences in mortality between infections due to extended-spectrum-beta-lactamase–producing Klebsiella pneumoniae and Escherichia coli

Burnham

Kwon

Olsen

et al. 2018

Infect. Control Hosp. Epidemiol.

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“…Interestingly, we previously showed that BSI severity or mortality among spinal cord injury patients over 15 years was not related to the multidrug-resistant characteristics of the microorganism 7 . Although our sample size was small (n<30), a closer look at the outcome between ESBL-EC (n=26) and ESBL-KP (n=13) did not reveal any statistical difference in terms of mortality rate (7.7% in each arm).…”

mentioning

confidence: 59%

“…Such data underly the hypothesis that ESBL-KP infections might have been more severe than those due to ESBL-EC. For instance, multidrug-resistant BSIs complicating respiratory tract infections have been associated with an increased mortality (odds ratio [OR], 3.26; 95% confidence interval [CI], 1.29–8.22) 7 …”

mentioning

confidence: 99%

Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli versus Klebsiella pneumoniae: Does type of germ really matter?

Truchis

Lawrence

Dinh

2018

Infect. Control Hosp. Epidemiol.

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The presence of cluster I in both ICUs, identical to the endemic cluster described by Saalffeld et al, 4 demonstrates the importance of interhospital dissemination. Although the environment was not the main cause of dissemination, we believe that the contamination of the hands of healthcare professionals may have contributed to the dissemination of A. baumannii isolates, and the failure to verify this dissemination route was a limiting factor in our study. Our study showed that after the ICU was re-established in a new building (ie, a new ICU), the dissemination of endemic clone-producing OXA-23 was maintained even though the new ICU environment was not contaminated. This occurrence demonstrates that additional measures are required to control the dissemination of this important hospital pathogen. Financial support. No financial support was provided relevant to this article.

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“…Blood stream infection secondary to urinary tract infections, pneumonia, pressure ulcers [48], catheter-related bloodstream infections [54], and infections at other sites may occur in SCI patients. Meningitis may occur after penetrating injuries or as a result of CSF leakage at the time of injury or subsequent to surgery [48].…”

Section: Other Infectionsmentioning

confidence: 99%

Infectious Complications after Spinal Cord Injury

Farhad¹,

Korooni²

2018

Essentials of Spinal Cord Injury Medicine

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Infectious diseases after spinal cord injury (SCI) are important. They can cause mortality and morbidity. The SCI patients usually stay in hospital or rehabilitation units for a long time, and this can cause several complications for them. Infectious complications: There are several infectious complications in these patients. Pressure ulcers that may be infected, soft tissue infections, osteomyelitis, pneumonia, urinary tract infection, bacteremia, meningitis, epidural abscess, and subdural empyema are important complications. These diseases should be diagnosed and managed promptly, before leading to irreversible complications or death. Diagnosis: Diagnosis is made by physical examinations; laboratory tests like wound, urine, tracheal secretion, and blood culture with antibiogram; and radiologic evaluation like plain X-ray and magnetic resonance imaging may be used. Treatment: Appropriate antibiotics are cornerstone of infectious complications. Offloading is important for treatment of pressure ulcers and subsequent complications such as soft tissue infection and osteomyelitis. Prevention: Intermittent urinary catheterization and prophylactic antibiotic therapy can decrease UTI. Pressure relief, position changes, and regular and frequent observation of skin will prevent pressure ulcers, soft tissue infections, and osteomyelitis. Pulmonary toilet, appropriate positioning, and cough assistance can be useful for clearing retained secretions and preventing pneumonia.

show abstract

Outcome of bloodstream infections among spinal cord injury patients and impact of multidrug-resistant organisms

Cited by 10 publications

References 27 publications

Differences in mortality between infections due to extended-spectrum-beta-lactamase–producing Klebsiella pneumoniae and Escherichia coli

Differences in mortality between infections due to extended-spectrum-beta-lactamase–producing Klebsiella pneumoniae and Escherichia coli

Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli versus Klebsiella pneumoniae: Does type of germ really matter?

Infectious Complications after Spinal Cord Injury

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