Outbreak of surgical infection caused by non-tuberculous mycobacteria in breast implants in Brazil

Padoveze, Maria Clara; Fortaleza, Carlos Magno Castelo Branco; Freire, Maristela Pinheiro; Assis, Denise Brandão de; Madalosso, Geraldine; Pellini, Alessandra Cristina Guedes; César, M.L.V.; Neto, VA; Beltramelli, Matilde; Chimara, Érica; Ferrazoli, Lucilaine; Telles, María Alice da Silva; Sampaio, Jorge Luiz Mello; Leão, Sylvia Cardoso

doi:10.1016/j.jhin.2007.07.007

Cited by 48 publications

(40 citation statements)

References 16 publications

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“…The risk of NTM infection in reconstructive breast surgery has a worldwide incidence of 4.8% to 17.8% but there are no data concerning its occurrence in Brazil (7,28) . The complications of this surgery are significant causes of morbidity, many of which are related to the healing of wounds and viability of the breast implant (28) .…”

Section: Discussionmentioning

confidence: 99%

“…Padoveze MC, Fortaleza CM, Freire MP, Bran dão de Assis D, Madalosso G , Pellin i AC et al (7 ) To describe outbreak caused by NTM after breast implant surgeries.…”

Section: VIImentioning

confidence: 99%

“…Various species have been identified and for a long time these microorganisms were called environmental mycobacteria and then "atypical" mycobacteria or NTM or fast-growing bacteria (1) . NTM infections are more frequent on the skin and subcutaneous tissue and in general are associated with cosmetic surgical procedures such as liposuction or liposculpture (6) , injectable solutions such as procaine, Lcarnitine, C vitamin, and lidocaine and after injection of silicone in mammary prosthesis (7) ; acupuncture treatment; placement of nipple piercing and skin infections after tattooing (8) .…”

Section: Introductionmentioning

confidence: 99%

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Micobactérias não tuberculosas em cirurgias: desafio passível de enfrentamento no Brasil?

Cabral¹,

Andrade

2011

Acta paul. enferm.

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Infections caused by nontuberculous mycobacteria (MNT) represent an epidemiological and health emergency, especially in patients undergoing invasive procedures. Based on these, we aimed to analyze the scientific evidence, the scientific literature, on the occurrence in Brazil of MNT infections in surgical patients. We used as a research method integrative review of the literature using the databases Lilacs, Medline/Pubmed, ISI Web of Science and the Cochrane Library. We selected 15 publications on this theme from the last 30 years that were directed at methods of prevention and control, with a focus on post-discharge surveillance, the use of antibiotics and glutaraldehyde. Eye surgery, cosmetic, heart, laparoscopic and arthroscopic procedures were the most commonly investigated. The national situation of MNTs is concerning, especially when one recognizes the possibility of underreporting. Keywords: Mycobacteria, atypical; Surgical procedures operative; Mycobacterium infections atypical RESUMOInfecções por micobactéria não tuberculosa (MNT) representam uma emergência epidemiológica e sanitária, especialmente, em pacientes submetidos a procedimentos invasivos. Frente ao exposto, objetivou-se analisar as evidências científicas, na literatura científica, sobre a ocorrência no Brasil de infecções por MNT em pacientes cirúrgicos. Utilizou-se como método de pesquisa a revisão integrativa da literatura nas bases de dados Lilacs, Medline/Pubmed, ISI Web of Science e Biblioteca Cochrane. Foram selecionadas 15 publicações sobre a temática nos últimos 30 anos que estavam direcionadas às medidas de prevenção e controle com foco na vigilância pós-alta, no uso de antibioticoterapia e glutaraldeído. Cirurgias oftalmológicas, estéticas, cardíacas e procedimentos laparoscópicos e artroscópicos foram as mais investigadas. A situação nacional das MNTs é preocupante, ainda mais quando se reconhece a possibilidade de subnotificação. Descritores: Micobactérias atípicas; Procedimentos cirúrgicos operatórios; Infecções atípicas por Mycobacterium RESUMENLas infecciones por micobacteria no tuberculosa (MNT) representan una emergencia epidemiológica y sanitaria, especialmente, en pacientes sometidos a procedimientos invasivos. Frente a lo expuesto, se tuvo como objetivo analizar las evidencias científicas, en la literatura científica, sobre la ocurrencia en el Brasil de infecciones por MNT en pacientes quirúrgicos. Se utilizó como método de investigación la revisión integrativa de la literatura en las bases de datos Lilacs, Medline/Pubmed, ISI Web of Science y Biblioteca Cochrane. Se seleccionaron 15 publicaciones sobre la temática en los últimos 30 años que estaban orientadas a las medidas de prevención y control con foco en la vigilancia post alta, en el uso de antibioticoterapia y glutaraldehido. Cirugías oftalmológicas, estéticas, cardíacas y procedimientos laparoscópicos y artroscópicos fueron las más investigadas. La situación nacional de las MNTs es preocupante, aun más cuando se reconoce la posibilidad de subnotificación.

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Section: Discussionmentioning

confidence: 99%

“…Padoveze MC, Fortaleza CM, Freire MP, Bran dão de Assis D, Madalosso G , Pellin i AC et al (7 ) To describe outbreak caused by NTM after breast implant surgeries.…”

Section: VIImentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Micobactérias não tuberculosas em cirurgias: desafio passível de enfrentamento no Brasil?

Cabral¹,

Andrade

2011

Acta paul. enferm.

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“…All these outbreaks were restricted to determined ophthalmologic clinics and no specific source of transmission was detected. Other outbreaks of RGM infections were also related to esthetics procedures such as mesotherapy in 2000 and 2002, in the state of São Paulo, and were associated to M. chelonae and M. abscessus species, respectively 6 6,7 .…”

Section: Discussionmentioning

confidence: 99%

“…In Brazil, infections related to RGM species have been documented and usually described as sporadic cases of skin or lung infections in routine clinical laboratories, or short outbreaks related to breast implant surgery, laser in situ keratomileusis (LASIK) or mesotherapy sessions [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium massiliense BRA100 strain recovered from postsurgical infections: resistance to high concentrations of glutaraldehyde and alternative solutions for high level disinfection

Lorena

Pitombo

Côrtes³

et al. 2010

Acta Cir. Bras.

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Purpose:To evaluate the minimum inhibitory concentration (MIC) of GTA against these microorganisms and alternative disinfectants for high-level disinfection (HLD). Methods: Reference mycobacteria and clinical M. massiliense strains were included in this study. Active cultures were submitted to susceptibility qualitative tests with GTA dilutions (ranging from 1.5% to 8%), and commercial orthophthaldehyde (OPA) and peracetic acid (PA) -based solutions, during the period of exposure as recommended by National Agency of Sanitary Surveillance for HLD. Results: All reference and M. massiliense non-BRA100 strains, recovered from sputum, were susceptible to any GTA concentration, OPA and PA solutions. M. massiliense BRA100 strains presented MIC of 8% GTA and were susceptible to OPA and PA. Conclusion: M. massiliense BRA100 strain is resistant to high GTA concentrations (up to 7%), which proves that this product is non-effective against specific rapidly growing mycobacteria and should be substituted by OPA or PA -based solutions for HLD. Key words: Mycobacterium Infections. Videolaparoscopy. Disinfection. Glutaraldehyde. RESUMOObjetivo: Avaliar a concentração mínima inibitória (CMI) de GTA frente a M. massiliense e a susceptibilidade a produtos alternativos para desinfecção de alto nível (DAN). Métodos: Cepas de M. massiliense de origem clínica e de referência foram incluídas no estudo. As culturas ativadas foram submetidas a testes qualitativos com diluições de GTA (de 1,5% a 8%) e com soluções comerciais de ortoftaldeído (OPA) ou ácido peracético (PA), utilizando os tempos de exposição recomendados pela Agência Nacional de Vigilância Sanitária para DAN. Resultados: Todas as cepas de referência e M. massiliense não-BRA100, obtida de escarro, foram susceptíveis às concentrações de GTA, e soluções de OPA e PA. As cepas de M. massiliense BRA100 apresentaram CMI de 8% para GTA e foram susceptíveis a OPA e PA. Conclusão: M. massiliense BRA100 é resistente a altas concentrações de GTA (até 7%), o que demonstra que esse composto não é eficaz, e deve ser substituído por OPA ou PA nos processos de DAN.

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Resazurin Microtiter Assay for Clarithromycin Susceptibility Testing of Clinical Isolates of Mycobacterium abscessus Group

Carvalho

Sato

Pavan

et al. 2016

Clinical Laboratory Analysis

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Outbreak of surgical infection caused by non-tuberculous mycobacteria in breast implants in Brazil

Cited by 48 publications

References 16 publications

Micobactérias não tuberculosas em cirurgias: desafio passível de enfrentamento no Brasil?

Micobactérias não tuberculosas em cirurgias: desafio passível de enfrentamento no Brasil?

Mycobacterium massiliense BRA100 strain recovered from postsurgical infections: resistance to high concentrations of glutaraldehyde and alternative solutions for high level disinfection

Resazurin Microtiter Assay for Clarithromycin Susceptibility Testing of Clinical Isolates of Mycobacterium abscessus Group

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