Outbreak of Salmonella enterica serotype Infantis producing ArmA 16S RNA methylase and CTX-M-15 extended-spectrum β-lactamase in a neonatology ward in Constantine, Algeria

Naas, Thierry; Bentchouala, Chafia; Cuzon, Gaëlle; Yaou, Sanàa; Lezzar, Abdesselam; Smati, F; Nordmann, Patrice

doi:10.1016/j.ijantimicag.2011.04.012

Cited by 35 publications

(28 citation statements)

References 22 publications

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“…In other settings, the trend is not noticeable among the few studies available. In the studied countries in Africa, the prevalence is widely different: in Algeria, it was between 16.4 and 31.4% in mainly urine samples (16–18, 21) and even 99% among Salmonella enterica in stool samples (19); 19 and 42.9%, respectively, in urine and stool samples in Egypt (23, 24); 32.6% among stool samples in Guinea-Bissau (26); 11.7–77.8% in mainly urine, blood, and stool samples from Tunisia (40, 42, 46, 51); 62.8% in stool and blood samples from Ethiopia (52; 38.3% in urine samples from Rwanda (55); 55.3 and 82.8% in stool samples from Cameroon (58, 59); 10.3–27.5% in mainly urine and stool samples from Nigeria (66, 69–72); and 8.8–13.1% in urine, nasopharyngeal, and wound samples from South Africa (74, 75, 77). …”

Section: Discussionmentioning

confidence: 99%

ESBL-producingEnterobacteriaceaein Africa – a non-systematic literature review of research published 2008–2012

Storberg

2014

Infection Ecology & Epidemiology

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Introduction Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBL) has been found all over the world, and risk factors for acquiring these bacteria involve hospital care and antibiotic treatment. Surveillance studies are present in Europe, North America, and Asia, but there is no summarizing research published on the situation in Africa.AimThis review aims to describe the prevalence of ESBL-producing Enterobacteriaceae in hospital and community settings in Africa and the ESBL genes involved.MethodA non-systematic literature search was performed in PubMed. All articles published between 2008 and 2012 were screened and read in full text. Relevant articles were assessed for quality of evidence and included in the review. Articles were divided into regional areas in Africa and tabulated.ResultsESBL-producing Enterobacteriaceae in hospitalized patients and in communities varies largely between countries and specimens but is common in Africa. ESBLs (class A and D) and plasmid-encoded AmpC (pAmpC) were regularly found, but carbapenemases were also present.ConclusionESBL-producing Enterobacteriaceae in hospital and community settings in Africa is common. Surveillance of antimicrobial resistance needs to be implemented in Africa to tailor interventions targeted at stopping the dissemination of ESBL-producing Enterobacteriaceae.

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Section: Discussionmentioning

confidence: 99%

ESBL-producingEnterobacteriaceaein Africa – a non-systematic literature review of research published 2008–2012

Storberg

2014

Infection Ecology & Epidemiology

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“…More recently, these plasmids have been able to acquire genes coding the emerging carbapenemase such as bla NDM-1 (Poirel et al, 2011b) and have been identified as epidemic plasmids in countries with a high prevalence of carbapenem resistance (Psichogiou et al, 2008). Other plasmids, such as IncL/M group are also able to carry bla CTX-M genes (i.e., bla CTX-M-3 and bla CTX-M-15 ) as well as those producing methylase encoding genes involved in aminoglycoside resistance (i.e., armA ; Sabtcheva et al, 2008; Naas et al, 2011). …”

Section: Genetic Environments Of Blactx-m Genes Participating In the mentioning

confidence: 99%

CTX-M Enzymes: Origin and Diffusion

Cantón¹,

González-Alba²,

Galán³

2012

Front. Microbio.

758

633

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CTX-M β-lactamases are considered a paradigm in the evolution of a resistance mechanism. Incorporation of different chromosomal blaCTX-M related genes from different species of Kluyvera has derived in different CTX-M clusters. In silico analyses have shown that this event has occurred at least nine times; in CTX-M-1 cluster (3), CTX-M-2 and CTX-M-9 clusters (2 each), and CTX-M-8 and CTX-M-25 clusters (1 each). This has been mainly produced by the participation of genetic mobilization units such as insertion sequences (ISEcp1 or ISCR1) and the later incorporation in hierarchical structures associated with multifaceted genetic structures including complex class 1 integrons and transposons. The capture of these blaCTX-M genes from the environment by highly mobilizable structures could have been a random event. Moreover, after incorporation within these structures, β-lactam selective force such as that exerted by cefotaxime and ceftazidime has fueled mutational events underscoring diversification of different clusters. Nevertheless, more variants of CTX-M enzymes, including those not inhibited by β-lactamase inhibitors such as clavulanic acid (IR-CTX-M variants), only obtained under in in vitro experiments, are still waiting to emerge in the clinical setting. Penetration and the later global spread of CTX-M producing organisms have been produced with the participation of the so-called “epidemic resistance plasmids” often carried in multi-drug resistant and virulent high-risk clones. All these facts but also the incorporation and co-selection of emerging resistance determinants within CTX-M producing bacteria, such as those encoding carbapenemases, depict the currently complex pandemic scenario of multi-drug resistant isolates.

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“…Of the CTX-M-producers (288 E. coli and 142 K. pneumoniae isolates) collected from 6 provinces in China during 1998–2002, CTX-M-14 was predominantly detected in 77.4% and 52.8% of the isolates, respectively, followed by CTX-M-3 (18.4% and 29.6%), CTX-M-24 (5.6% and 14.1%) and CTX-M-15 (0.7% and 1.4%) (Yu et al, 2007). An outbreak of CTX-M-producing S. enterica infection occurred in a university hospital in Algeria during 2008–2009, and all of 200 isolates from 138 patients were CTX-M-15 producers, identified to be a single clone (Naas et al, 2011). …”

Section: Epidemiology Of Ctx-m Esblsmentioning

confidence: 99%

Epidemiology and genetics of CTX-M extended-spectrum β-lactamases in Gram-negative bacteria

Zhao

2012

Critical Reviews in Microbiology

256

211

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CTX-M enzymes, the plasmid-mediated cefotaximases, constitute a rapidly growing family of extended-spectrum β-lactamases (ESBLs) with significant clinical impact. CTX-Ms are found in at least 26 bacterial species, particularly in Escherichia coli , Klebsiella pneumoniae and Proteus mirabilis. At least 109 members in CTX-M family are identified and can be divided into seven clusters based on their phylogeny. CTX-M-15 and CTX-M-14 are the most dominant variants. Chromosome-encoded intrinsic cefotaximases in Kluyvera spp. are proposed to be the progenitors of CTX-Ms, while IS Ecp1 , IS CR1 and plasmid are closely associated with their mobilization and dissemination.

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Outbreak of Salmonella enterica serotype Infantis producing ArmA 16S RNA methylase and CTX-M-15 extended-spectrum β-lactamase in a neonatology ward in Constantine, Algeria

Cited by 35 publications

References 22 publications

ESBL-producingEnterobacteriaceaein Africa – a non-systematic literature review of research published 2008–2012

ESBL-producingEnterobacteriaceaein Africa – a non-systematic literature review of research published 2008–2012

CTX-M Enzymes: Origin and Diffusion

Epidemiology and genetics of CTX-M extended-spectrum β-lactamases in Gram-negative bacteria

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