Outbreak of Listeriosis in South Africa Associated with Processed Meat

Thomas, Juno; Govender, Nevashan; McCarthy, Kerrigan; Erasmus, Linda; Doyle, Timothy J.; Allam, Mushal; Ismail, Arshad; Ramalwa, Ntsieni; Sekwadi, Phuti; Ntshoe, Genevie; Shonhiwa, Andronica Moipone; Essel, Vivien; Tau, Nomsa P.; Smouse, Shannon Lucrecia; Ngomane, Hlengiwe M; Disenyeng, Bolele; Page, Nicola; Govender, Nelesh P.; Dusé, Adriano; Stewart, R. E.; Thomas, Tincy; Mahoney, Deon; Tourdjman, Mathieu; Disson, Olivier; Thouvénot, Pierre; Maury, Mylène M.; Leclercq, Alexandre; Lecuit, Marc; Smith, Anthony M.; Blumberg, Lucille

doi:10.1056/nejmoa1907462

“…Strains of at least five of the L. monocytogenes clusters were persistent in the food processing plant and have been detected for nine months to four years. This long period of time may explain the comparatively large allele and SNP distance [12,[41][42][43] between the epidemiologically linked isolates in our study. Furthermore, in three of those clusters, strains were found in both, food and food processing environment, verifying cross-contamination events.…”

Section: Discussionmentioning

confidence: 99%

Backtracking and forward checking of human listeriosis clusters identified a multiclonal outbreak linked to Listeria monocytogenes in meat products of a single producer

Lüth

¹

,

Halbedel

²

,

Rosner

³

et al. 2020

Emerging Microbes & Infections

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“…Pregnancy-associated listeriosis cases includes illness with an onset during pregnancy or within the rst 2 weeks of the postpartum period as well as illness in the neonate between birth and 4 weeks of age [18] . All the con rmed cases were based on the isolation of L. monocytogenes from a normally sterile site (e.g., blood or cerebrospinal uid [CSF]) or products of conception (e.g., placental or fetal tissue), with the presence of compatible clinical symptoms.…”

Section: Methodsmentioning

confidence: 99%

Perinatal listeriosis patients treated at a maternity hospital in Beijing, China, from 2013-2018

Li

¹

,

Zeng

²

,

Ding

³

et al. 2020

Preprint

1

5

0

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Background: Listeriosis is a rare but severe foodborne infectious disease. Perinatal listeriosis is often associated with septicemia, central nervous system (CNS) infection, and serious adverse pregnancy outcomes (miscarriage and neonate death). Here we report the characteristics and outcomes of perinatal listeriosis cases treated over 6 years at Beijing Obstetrics and Gynecology Hospital (BOGH), the largest maternity hospital in China. Methods: We retrospectively reviewed the records of laboratory-confirmed, pregnancy-associated listeriosis cases treated from January 1, 2013 to December 31, 2018. The clinical manifestations, laboratory results, perinatal complications and outcomes (post-natal follow-up of 6 months) were investigated. Results: In BOGH, 12 perinatal listeriosis cases were diagnosed based on Listeria monocytogenes positive culture, including 10 single pregnancies and 2 twin pregnancies. The corresponding incidence of pregnancy-associated listeriosis was 13.7/100,000 deliveries. Among those cases, four pregnant women and four newborns had septicemia, and two of the neonates with septicemia also suffered CNS infection. All the maternal patients recovered. Two inevitable miscarriages and four fetal stillbirths occurred. Of the eight delivered newborns, six survived, and two died within 2 days from birth. None of the survivors had neurological sequelae during a 6-month follow-up. The overall feto-neonatal fatality rate was 57.1%; notably, this rate was 100% for infections occurring during the second trimester of pregnancy and only 14.3% for those occurring in the third trimester. Conclusions: Perinatal listeriosis is associated with high feto-neonatal mortality, and thus, a public health concern. Additional large-scale studies are needed to strengthen the epidemiological understanding of listeriosis in China.

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“…This report retrospectively reviewed all laboratoryconfirmed, pregnancy-associated listeriosis cases treated from January 2013 to December 2018 at Beijing Obstetrics and Gynecology Hospital (BOGH), a high-level maternal and child health care hospital with 660 beds in Beijing, China. 1 In the present study, we detail the clinical characteristics and outcomes of these L. monocytogenes infected perinatal patients.…”

Section: Introductionmentioning

confidence: 99%

Perinatal listeriosis patients treated at a maternity hospital in Beijing, China, from 2013–2018

Li

¹

,

Ding

²

,

Chen

³

et al. 2020

View full text Add to dashboard Cite

Background: Listeriosis is a rare but severe foodborne infectious disease. Perinatal listeriosis is often associated with septicemia, central nervous system (CNS) infection, and serious adverse pregnancy outcomes (miscarriage and neonate death). Here we report the characteristics and outcomes of perinatal listeriosis cases treated over 6 years at Beijing Obstetrics and Gynecology Hospital (BOGH), the largest maternity hospital in China. Methods: We retrospectively reviewed the records of laboratory-confirmed, pregnancy-associated listeriosis cases treated from January 1, 2013 to December 31, 2018. The clinical manifestations, laboratory results, perinatal complications and outcomes (post-natal follow-up of 6 months) were investigated. Results: In BOGH, 12 perinatal listeriosis cases were diagnosed based on Listeria monocytogenes positive culture, including 10 single pregnancies and 2 twin pregnancies. The corresponding incidence of pregnancy-associated listeriosis was 13.7/100,000 deliveries. Among those cases, four pregnant women and four newborns had septicemia, and two of the neonates with septicemia also suffered CNS infection. All the maternal patients recovered. Two inevitable miscarriages and four fetal stillbirths occurred. Of the eight delivered newborns, six survived, and two died within 2 days from birth. None of the survivors had neurological sequelae during a 6-month follow-up. The overall feto-neonatal fatality rate was 57.1%; notably, this rate was 100% for infections occurring during the second trimester of pregnancy and only 14.3% for those occurring in the third trimester. Conclusions: Perinatal listeriosis is associated with high feto-neonatal mortality, and thus, a public health concern. Additional large-scale studies are needed to strengthen the epidemiological understanding of listeriosis in China.

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Outbreak of Listeriosis in South Africa Associated with Processed Meat

Cited by 156 publications

References 28 publications

Backtracking and forward checking of human listeriosis clusters identified a multiclonal outbreak linked to Listeria monocytogenes in meat products of a single producer

Backtracking and forward checking of human listeriosis clusters identified a multiclonal outbreak linked to Listeria monocytogenes in meat products of a single producer

Perinatal listeriosis patients treated at a maternity hospital in Beijing, China, from 2013-2018

Perinatal listeriosis patients treated at a maternity hospital in Beijing, China, from 2013–2018

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