Outbreak of autochthonous canine visceral leishmaniasis in Santa Catarina, Brazil

Steindel, Mário; Menin, Álvaro; Evangelista, Tatiane da Silva; Stoco, Patrícia Hermes; Marlow, Mariel; Fleith, Renata; Pilati, Célso; Grisard, Edmundo Carlos

doi:10.1590/s0100-736x2013000400013

Cited by 21 publications

(20 citation statements)

References 40 publications

(37 reference statements)

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“…Lutzomyia cruzi e Lutzomyia forattinii são vetores potenciais no estado do Mato Grosso do Sul (Pita-Pereira et al 2008). Os cães desempenham um papel importante na manutenção e transmissão da infecção, especialmente na presença de vetores competentes e hospedeiros susceptíveis (Steindel et al 2013). A Organização Pan-americana de Saúde (OPAS) define que os cães são os principais reservatórios da LV para o homem e que são necessárias estratégias de controle da leishmaniose visceral canina (LVC) para diminuir os casos humanos e a propagação da doença (OPAS 2009 No Brasil, a região Nordeste é a que apresenta a prevalência mais alta da LVC, entretanto o índice pode variar de 0,7% a 51,61% (Abreu- Silva et al 2008, Barbosa et al 2009, Fernandes et al 2016), e com níveis mais altos na zona rural em relação à área urbana (Amóra et al 2006.…”

Section: Introductionunclassified

Leishmaniose visceral em cães de assentamentos rurais

Silva

Melo

Costa³

et al. 2017

Pesq. Vet. Bras.

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RESUMO.-Nos assentamentos rurais há maiores concentrações de reservatórios e vetores da leishmaniose visceral canina (LVC) devido às transformações ambientais resultantes da ação antrópica pela ocupação do território, no entanto, não há estudos no Brasil acerca de informações epidemiológicas da LVC em assentamentos rurais. O objetivo do presente trabalho foi determinar a soroprevalência para Leishmania sp. em cães de assentamentos rurais, bem como identificar os fatores de risco associados a infecção. Foram utilizados 306 cães e o diagnóstico sorológico da LVC foi realizado através do ELISA S7. Dos 306 cães investigados, 118 apresentaram anticorpos anti-Leishmania sp., resultando em frequência de 38,6%. Idade de 12 -24 meses (OR=2,97), idade de 24--48 meses (OR=4,83), idade de 4-6 anos (OR=4,40), idade >6 anos (OR=3,62), contato com aves (OR=1,67) e sexo (fêmea) (OR=1,97) foram apontados como fatores de risco para LVC. Cães de assentamentos rurais do semiárido paraibano apresentaram frequência elevada de anticorpos anti-Leishmania sp., o que torna a população desses locais susceptíveis à infecção. Isso evidencia a necessidade de alerta aos órgãos de vigilância epidemiológica para estabelecer medidas de prevenção e controle dessa zoonose, incluindo ações educacionais e sanitárias nesses assentamentos, já que os mesmos estão situados em áreas com características propícias à instalação da LVC. In rural settlements there are higher concentrations of reservoirs and vectors of canine visceral leishmaniasis (CVL) due to environmental changes resulting from human action by occupation of the territory, however, there are no surveys in Brazil on epidemiological information of CVL in these areas. The aim of this study was to determine the seroprevalence of Leishmania sp. in dogs from rural settlements, as well as to identify the risk factors associated with infection. A total of 306 dogs were tested, and the serological diagnosis of CVL was performed by ELISA S7. Of the 306 dogs, 118 presented anti-Leishmania sp. antibodies., resulting in a frequency of 38.6%. The risk factors identified for CVL seropositivity were: age of 12-24 months (OR=2.97), age of 24-48 months (OR=4.83), age of 4-6 years (OR=4.40), age >6 years (OR=3.62), contact with poultry (OR=1.67) and gender (female) (OR=1.97). Dogs from rural settlements in the semiarid of Paraiba showed high anti-Leishmania sp. antibody frequency, what makes the population of those settlements susceptible to infection. This highlights for the need to alert the epidemiological surveillance agencies to stablish prevention and control methods for that zoonosis, including educational and health activities on these settlements, as they are located in areas with favorable characteristics for CVL installation.

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Section: Introductionunclassified

Leishmaniose visceral em cães de assentamentos rurais

Silva

Melo

Costa³

et al. 2017

Pesq. Vet. Bras.

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“…Figueiredo et al (2012) described the first autochthonous cVL cases in the city of Florianópolis. Afterwards, an epidemiological survey was conducted on 2,124 dogs from seven districts in the city of Florianópolis, and the prevalence was 1.4% (29/2,124)(STEINDEL et al, 2013).…”

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confidence: 99%

Variables associated with the prevalence of anti-Leishmania spp. antibodies in dogs on the tri-border of Foz do Iguaçu, Paraná, Brazil

Dias

Soccol

Pasquali

et al. 2018

Rev. Bras. Parasitol. Vet.

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The aim of this study was to investigate the occurrence of anti-Leishmania spp. antibodies in dogs from localities in the city of Foz do Iguaçu, Paraná state, Brazil, on the border with Argentina and Paraguay. Blood samples dogs were collected to perform the following serologic tests: immunochromatographic DPP® rapid test, indirect immunoenzymatic assay (ELISA) and indirect immunofluorescence assay (IFA). In 2012, 285 dogs were analyzed on Argentina border, and in 2013, serum samples from 396 dogs on the border of Paraguay were collected. Using ELISA for screening and IFA for the confirmatory test, the results showed that the antibody prevalence was 1.8% (5/285) on the border of Argentina and 3.0% (12/396) on Paraguay border. When using the DPP® for screening and ELISA as a confirmatory analysis, we observed a seroreagent prevalence in dogs of 2.5% (7/285) on Argentina border and 5.1% (20/396) on Paraguay border. The non-public collection of domestic waste (p= 0.0004) was shown to be associated with leishmaniasis. This study shows the presence of leishmaniasis and suggest the emergence of canine visceral leishmaniasis in state of Paraná due to the confirmed occurrence of seroreactive dogs on Argentina and Paraguay border, which has environmental and geographical characteristics that favor the spread of the parasite.

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“…Dispersion of VL in the Southern Region of Brazil has been more recent. The first records of cVL and hVL in this region were in the state of Rio Grande do Sul in 2006 and 2008, respectively [38], followed by the state of Santa Catarina in 2011 [39,40]. In the state of Paraná the first detection of vectors and dogs diagnosed with cVL was in 2012, while the first human case was recorded in 2016 [41–45].…”

Section: Introductionmentioning

confidence: 99%

Dispersion of Leishmania (Leishmania) infantum in central-southern Brazil: Evidence from an integrative approach

et al. 2019

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Leishmania (Leishmania) infantum is the zoonotic agent of visceral leishmaniasis (VL), a disease with a global distribution. The transmission scenario of VL has been undergoing changes worldwide, with the biologic cycle invading urbanized areas and dispersing the parasites into other previously free areas. The epidemiological cycle in Brazil has dispersed from the Northeast to other regions of the country. In this study, an integrative approach, including genotyping Brazilian strains of L . (L . ) infantum for 14 microsatellite markers and reviewing historical records of the disease, was used to assess dispersion routes throughout central-southern Brazil. Our results support three L . (L . ) infantum dispersion routes: A) dispersion from Bolivia to the states of Mato Grosso, Mato Grosso do Sul and São Paulo via the Bolivia-Brazil gas pipeline from 1998 to 2005; B) VL dispersion from Paraguay to the Brazilian side of the triple border (Foz do Iguaçu and Santa Terezinha de Itaipu) during after 2012; and C) emergence of a new L . (L . ) infantum cluster in western Santa Catarina State and its dispersion to southern Paraná State (municipality of Pato Branco), after 2013. Hypotheses regarding possible entries of Leishmania (L . ) infantum into the area of the triple border are presented and discussed. Understanding how VL has dispersed is vital to the development of control measures for this disease and to avoid future dispersion events.

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Outbreak of autochthonous canine visceral leishmaniasis in Santa Catarina, Brazil

Cited by 21 publications

References 40 publications

Leishmaniose visceral em cães de assentamentos rurais

Leishmaniose visceral em cães de assentamentos rurais

Variables associated with the prevalence of anti-Leishmania spp. antibodies in dogs on the tri-border of Foz do Iguaçu, Paraná, Brazil

Dispersion of Leishmania (Leishmania) infantum in central-southern Brazil: Evidence from an integrative approach

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