Otitis in the Allergic Dog

Noxon, James O.

doi:10.1002/9781118738818.ch27

Cited by 2 publications

(5 citation statements)

References 30 publications

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“…1,2 Otitis externa is often complicated by bacterial and/or yeast (Malassezia) infection that requires specific otic topical therapy. 3,4 Treatment protocols for this purpose are usually based on ear cleaning, aimed at eliminating excessive debris and exudates, followed by once or twice daily administration of antibacterial/antimycotic/corticosteroid-containing otic solutions. 4 Therapeutic courses typically last 1-3 weeks and are usually performed at home by the owners.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Treatment protocols for this purpose are usually based on ear cleaning, aimed at eliminating excessive debris and exudates, followed by once or twice daily administration of antibacterial/antimycotic/corticosteroid-containing otic solutions. 4 Therapeutic courses typically last 1-3 weeks and are usually performed at home by the owners. Treatment compliance is very important for successful therapy; however, the administration of ear cleaners and medication is not always easy to perform in refractory patients.…”

Section: Introductionmentioning

confidence: 99%

“…Otitis externa is a common skin disease in dogs, accounting for 22% of dermatology patients and 13–16% of the general hospital population . Otitis externa is often complicated by bacterial and/or yeast ( Malassezia ) infection that requires specific otic topical therapy . Treatment protocols for this purpose are usually based on ear cleaning, aimed at eliminating excessive debris and exudates, followed by once or twice daily administration of antibacterial/antimycotic/corticosteroid‐containing otic solutions .…”

Section: Introductionmentioning

confidence: 99%

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Impact of a terbinafine–florfenicol–betamethasone acetate otic gel on the quality of life of dogs with acute otitis externa and their owners

Noli¹,

Sartori²,

Cena

2017

Veterinary Dermatology

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Background -Treatment of canine otitis externa with owner-administered products can be difficult.Objectives -To evaluate otic treatment administered by a veterinarian on quality of life (QoL) of dogs with otitis externa and their owners, and on clinical and cytology parameters of otitis; compared to an owner-administered treatment.Animals -Fifty client-owned dogs randomly randomized into two groups and treated for 2 weeks.Methods -Veterinarians treated Group A dogs with a veterinary licensed otic gel on two occasions at a 1 week interval; owners treated Group B dogs once daily with a veterinary licensed otic drop based product along with twice weekly cleaning. Veterinarians evaluated otitis with the OTI-3 scale and semi-quantitative cytological examination on days 0, 7, 14 and 28. At each visit, owners assessed QoL with a validated questionnaire and pruritus with a Visual Analog Scale. Scores before and after treatment of each group, and differences between groups were analysed statistically.Results -In both groups, all parameters improved significantly. There was a significantly higher improvement of QoL scores, for dogs and owners, in Group A, compared to Group B at all time points (P < 0.05), except for owner QoL on Day 28. There was no difference in improvement of OTI-3 between groups at any time point, whereas Group A cytology scores and pruritus improved significantly more by Day 7 (P = 0.0026 and P = 0.0294, respectively).Conclusion -A veterinarian-administered otic gel provided equivalent efficacy and higher QoL to dogs with otitis externa and their owners, compared to an owner-administered topical otic therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of a terbinafine–florfenicol–betamethasone acetate otic gel on the quality of life of dogs with acute otitis externa and their owners

Noli¹,

Sartori²,

Cena

2017

Veterinary Dermatology

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“…Many commercial products contain propylene glycol which can cause contact reactions in some dogs. 19 A combination of topical 0.1% dexamethasone with propylene glycol can increase the potential for adrenal suppression compared with 0.1% dexamethasone with normal saline in healthy dogs. 20 In dogs with OE that have severe ear canal inflammation and for which glucocorticoids or propylene glycol are contraindicated, clinicians can prepare an off-label otic solution that contains dexamethasone at a lower concentration or without propylene glycol as the vehicle.…”

Section: Discussionmentioning

confidence: 99%

“…Other limitations of commercial preparations include systemic adverse effects and the inclusion of potentially irritating substances. Many commercial products contain propylene glycol which can cause contact reactions in some dogs 19 . A combination of topical 0.1% dexamethasone with propylene glycol can increase the potential for adrenal suppression compared with 0.1% dexamethasone with normal saline in healthy dogs 20 .…”

Section: Discussionmentioning

confidence: 99%

The stability and in vitro antibacterial efficacy of enrofloxacin and gentamicin solutions against Staphylococcus pseudintermedius over 28 days

Park

Bae

2022

Veterinary Dermatology

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Background Many clinicians prepare compounded otic solutions to treat otitis externa (OE). Research evaluating the stability and antimicrobial efficacy of these solutions is limited. Hypothesis/Objectives This study determined the chemical stability and in vitro bactericidal efficacy of compounded solutions of enrofloxacin and gentamicin during storage for 28 days. Materials and methods Solutions of enrofloxacin (10 mg/mL, 1%) and gentamicin (3 mg/mL, 0.3%) were prepared with normal saline and 1 mg/mL dexamethasone. Solutions were stored at room temperature (25°C) for 0, 14 and 28 days. The chemical stability of the antibiotics and dexamethasone were determined using liquid chromatography tandem mass spectrometry in triplicate. Efficacy assessment was made with 10 isolates of Staphylococcus pseudintermedius obtained from dogs with OE. Serial 10‐fold dilutions of the bacteria with the compounded solutions were prepared and the colony count results were converted into colony‐forming units (cfus). The mean cfu/mL and cfu/mL reduction rates were compared between Day (D)0, D14 and D28. All of the antimicrobial testing solutions were performed in triplicate. Results Chromatography showed that both antibiotics and dexamethasone were stable for 28 days. No significant differences were observed in the antibiotic bactericidal efficacy of stored solutions at D0, D14 or D28. Conclusions and Clinical Relevance Solutions of 1% enrofloxacin and 0.3% gentamicin in normal saline with 0.1% dexamethasone maintained chemical stability and bactericidal efficacy over 28 days. These solutions can be considered as alternatives to commercial preparations for treatment of canine OE when indicated.

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Otitis in the Allergic Dog

Cited by 2 publications

References 30 publications

Impact of a terbinafine–florfenicol–betamethasone acetate otic gel on the quality of life of dogs with acute otitis externa and their owners

Impact of a terbinafine–florfenicol–betamethasone acetate otic gel on the quality of life of dogs with acute otitis externa and their owners

The stability and in vitro antibacterial efficacy of enrofloxacin and gentamicin solutions against Staphylococcus pseudintermedius over 28 days

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