17The U.S. Department of Energy Systems Biology Knowledgebase (KBase) is an open-source 18 software and data platform designed to meet the grand challenge of systems biology-19 predicting and designing biological function from the biomolecular (small scale) to the ecological 20 (large scale). KBase is available for anyone to use, and enables researchers to collaboratively 21 generate, test, compare, and share hypotheses about biological functions; perform large-scale 22 analyses on scalable computing infrastructure; and combine experimental evidence and 23conclusions that lead to accurate models of plant and microbial physiology and community 24 dynamics. The KBase platform has (1) extensible analytical capabilities that currently include 25 genome assembly, annotation, ontology assignment, comparative genomics, transcriptomics, 26 and metabolic modeling; (2) a web-browser-based user interface that supports building, sharing, 27and publishing reproducible and well-annotated analyses with integrated data; (3) access to 28 extensive computational resources; and (4) a software development kit allowing the community 29to add functionality to the system. 30
The purpose of this study was to determine the relationships among body condition score (BCS), radiography, and computed tomography (CT), and to establish a method for body fat assessment on CT in dogs. Thirty eight Beagles with 2 to 7 BCS were examined. Subcutaneous fat thickness (ST) on radiograph and body area (BA), total fat area (TA), subcutaneous fat area (SA), and visceral fat area (VA) on CT were measured at the level of L3 and L6 vertebra. Ratios of each value to the L6 length were obtained (rST, rTA, rSA, rVA) and the correlations with BCS were estimated. The value of VA/SA, VA/TA, TA/BA, VA/BA, and SA/BA were selected for measuring fat and the correlations with BCS were estimated. The rST, rTA, rSA, and rVA were significantly correlated with BCS, and the rTA and rSA were significantly correlated with rST. At the level of L3, rTA and rVA had stronger relationships with BCS than at L6 while rSA had a higher correlation with BCS at L6. The TA/BA, VA/BA, and SA/BA were significantly correlated with BCS, and the upper limits were 15.11, 6.31, and 8.92%, respectively. Our results showed that CT could be useful to assess body fat and TA/BA, VA/BA, and SA/BA are suitable criteria for measuring fat on CT. In addition, L3 was a more suitable location for evaluating total and visceral fat, and L6 was more suitable for evaluating subcutaneous fat.
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