Osteosarcoma of the skin

Abstract

Although osteosarcoma is a common malignancy with frequent metastases, involvement of the skin is rare. Further studies to identify risk factors and subsequent prognosis are necessary. Nevertheless, unidentifiable skin lesions in a patient with a history of osteosarcoma should be investigated to rule out tumor metastasis, regardless of cancer status.

Metastasis of osteosarcoma to stomach made clinically evident by hematemesis: a case report

“…Immature new vessels may be associated with easy bleeding from the ulcer on the osteosarcoma gastric metastasis. Ulceration is not common in skin metastases of osteosarcoma [15], but is distinctive for gastric metastases of osteosarcoma. Local factors at the metastatic site may also be implicated in the occurrence of ulceration.…”

Isolated subcutaneous metastasis of osteosarcoma 5 years after initial diagnosis

“…Larsen et al [7] reviewed the case reports of cutaneous metastases of osteosarcoma that have been published in the past 10 years and reported a new case of a 12-year-old girl with a cutaneous metastases of osteosarcoma manifested as a ''keloid'' in the right scapular area 7 years after the initial diagnosis. In the reviewed cases, the median age at diagnosis of osteosarcoma was 31.9 years (range, 12-75 years).…”

Cutaneous Hematopathology

“…Both primary and metastatic cutaneous OS present as fi rm, fl esh-colored to red or violaceous (Collier et al 2003 ;Larsen et al 2010 ;Llamas-Velasco et al 2013 ;Massi et al 2007 ;Park et al 2011 ). ESOS most commonly occurs within the deep soft tissues of the extremities, and unlike its skeletal counterpart, ESOS primarily affects middle-aged to elderly adults Riddle et al 2009 ).…”

“…The clinical behavior of primary OS arising in the skin appears to parallel that of extracutaneous ESOS, in that local recurrence, as well as metastasis and death, may result (Kobos et al 1995 ;Park et al 2011 ;Riddle et al 2009 ;Salamanca et al 2008 ). Tumor size appears to most closely correlate with clinical outcome, however, this feature along with other prognostic indicators, including tumor histology, remain controversial (Larsen et al 2010 ;Park et al 2011 ). Like skeletal OS, extracutaneous ESOS can metastasize to the skin, and often metastasizes to the scalp (Covello et al 2003 ;Fernandez-Pineda et al 2011 ;Park et al 2011 ;Ragsdale et al 2011 ).…”