Isolated subcutaneous metastasis of osteosarcoma 5 years after initial diagnosis

Fernández-Pineda, Israel; Bahrami, Armita; Green, James F.; McGregor, Lisa M.; Davidoff, Andrew M.; Sandoval, John A.

doi:10.1016/j.jpedsurg.2011.06.011

Cited by 8 publications

(10 citation statements)

References 11 publications

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“…Interestingly, our data indicated that I3M treatment decreased the expression of survivin and FAK. Survivin, member of the inhibitor of apoptosis protein family (IAP), plays an important role in the abnormal proliferation of various cancers through the inhibition of apoptosis . Further investigations show that the survivin expression is associated with the cell cycle distribution, migration, invasion as well as the clinical staging, chemosensitivity, metastasis, recurrence, and prognosis .…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of indirubin‐3′‐monoxime against human osteosarcoma

Zhang

Song

et al. 2019

IUBMB Life

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Indirubin is widely used as the active component of “Dangui Luhui Wan” in ancient China. However, its effects against the osteosarcoma (OS), the most common primary malignancy, are still unknown. In our present study, we investigated the effects of the Indirubin‐3′‐monoxime (I3M), a derivative of indirubin with better water solubility, against the OS cells. We found I3M inhibited OS cell proliferation in a dose‐dependent manner. Flow cytometry assays showed that I3M could not only induce OS cell apoptosis in a time‐ and dose‐dependent manner but also regulate the cell cycle distribution. Additionally, we demonstrated that several Bcl‐2 family members, cyclin‐dependent kinases (CDKs) and cyclins contributed to this process. Furthermore, out data verified that I3M suppressed OS cell migration and invasion by decreasing MMP‐2 and MMP‐9 levels. Moreover, survivin and focal adhesion kinase (FAK) might play important roles in the anti‐OS effects of I3M. The administration of I3M also inhibited the OS cell growth in mice. Taken together, our results indicated the inhibitory effects of I3M against human OS and thus might be an efficient candidate for OS chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Inhibitory effects of indirubin‐3′‐monoxime against human osteosarcoma

Zhang

Song

et al. 2019

IUBMB Life

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“…OS is prone to aggressive biological behavior and development of distant metastasis (3)(4)(5). The currently used treatment for OS is neo-adjuvant chemotherapy followed by surgical resection, which has improved the five-year survival rate from 20 to 60% (6,7).…”

Section: Introductionmentioning

confidence: 99%

Bufalin induces apoptosis in the U-2OS human osteosarcoma cell line via triggering the mitochondrial pathway

Chen¹,

Li²,

Li³

et al. 2015

Molecular Medicine Reports

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Abstract. Bufalin has been shown to induce apoptosis in osteosarcoma cells; however, the underlying mechanism has not been elucidated. The purpose of the present study was to investigate whether mitochondria-mediated signaling pathways trigger the process of apoptosis in the U-2OS osteosarcoma cell line. Bufalin inhibited the proliferation and induced apoptosis in U-2OS cells in a time-and dose-dependent manner. Bufalin-induced apoptosis was accompanied with a significant reduction of the mitochondrial membrane potential, release of mitochondrial cytochrome c into the cytosol, activation of caspase-3, caspase-9 and poly(adenosine diphosphate ribose) polymerase, as well as downregulation of B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein. Cyclosporin A, a specific inhibitor of the mitochondrial permeability transition pore, attenuated bufalin-induced apoptosis. In conclusion, the present study revealed that bufalin induced apoptosis in the U-2OS human osteosarcoma cell line via triggering of the mitochondrial pathway.

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“…1 Although osteosarcoma is a highly aggressive malignancy and Figure 1 Tender, reddish to violaceous swelling patches over toes and nailfolds, mimicking paronychia or pernio metastasizes frequently to the lungs, bones, and kidney, cutaneous metastases is rarely seen. [2][3][4] Osteosarcoma metastasizes through a hematogenous system rather than lymphatic vessels. The initial clinical presentation may lead to a misdiagnosis of epidermal cyst or, less commonly, fibrous and vascular tumors.…”

Section: Discussionmentioning

confidence: 99%

Paronychia-like digital metastases of osteosarcoma

Lee

2016

Int J Dermatol

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Isolated subcutaneous metastasis of osteosarcoma 5 years after initial diagnosis

Cited by 8 publications

References 11 publications

Inhibitory effects of indirubin‐3′‐monoxime against human osteosarcoma

Inhibitory effects of indirubin‐3′‐monoxime against human osteosarcoma

Bufalin induces apoptosis in the U-2OS human osteosarcoma cell line via triggering the mitochondrial pathway

Paronychia-like digital metastases of osteosarcoma

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