Metastasis of osteosarcoma to stomach made clinically evident by hematemesis: a case report

Urakawa, Hiroshi; Tsukushi, Satoshi; Tsurudome, Issei; Hirata, Akihiro; Arai, Eisuke; Kozawa, Eiji; Futamura, Naohisa; Miyahara, Ryoji; Ishiguro, Naoki; Nishida, Yoshihiro

doi:10.1186/1477-7819-11-48

Cited by 10 publications

(12 citation statements)

References 14 publications

(23 reference statements)

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“…This regimen has already been widely used for adult patients with soft-tissue sarcoma ( 15 , 21 ). In the present study, only one patient discontinued chemotherapy due to a temporarily depressed level of consciousness with arrhythmia, suggesting that the combination of DXR and IFM is well tolerated, even in patients >60 years ( 22 ).…”

Section: Discussionmentioning

confidence: 55%

Neoadjuvant and adjuvant chemotherapy with doxorubicin and ifosfamide for bone sarcomas in adult and older patients

et al. 2014

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The present study investigated the safety and efficacy of neoadjuvant and adjuvant chemotherapy with doxorubicin and ifosfamide for bone sarcoma in adult and older patients. A total of 18 consecutive patients with bone sarcoma (American Joint Committee on Cancer stage II in 14 patients and stage IV in four) treated with neoadjuvant and adjuvant chemotherapy at Nagoya Musculoskeletal Oncology Group hospitals in Japan between 2004 and 2011 were reviewed. The treatment efficacy and side-effects were evaluated. The responses to neoadjuvant chemotherapy were stable disease in 11 patients and progressive disease in three. Among the 12 evaluable patients, there were five with ≥90% tumor necrosis. The estimated overall survival (OS) rate at five years for the patients without metastasis prior to treatment was 56%. Major grade 3 or 4 side-effects included leukopenia in 14 cases, anemia in seven, thrombocytopenia in three, nausea in two and febrile neutropenia in two. One patient discontinued chemotherapy due to a temporarily depressed level of consciousness with arrhythmia (grade 2). The estimated five-year OS rate in this study was acceptable in patients without metastasis prior to treatment. A better coordinated prospective study of this combination regimen for older patients with bone sarcoma will be required to clarify its efficacy and tolerability.

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Section: Discussionmentioning

confidence: 55%

Neoadjuvant and adjuvant chemotherapy with doxorubicin and ifosfamide for bone sarcomas in adult and older patients

et al. 2014

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“…To our knowledge, there are only 20 previously documented cases. Of these, 5 were to the stomach, [ 2 – 6 ] 3 were to the duodenum, [ 7 – 9 ] 8 were to the jejunum, [ 10 – 17 ] and 3 were to the ilium. [ 18 – 21 ] The metastasis localized in the stomach presented as anemia, hematemesis, and tarry stools.…”

Section: Discussionmentioning

confidence: 99%

Long-term survival after sporadic and delayed metastases of conventional osteosarcoma

Kubo

Furuta²,

Johan³

et al. 2017

Medicine

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Histologically conventional osteosarcoma, once metastasized to the lung, generally causes a rapid and fatal outcome. Osteosarcoma metastasis to the gastrointestinal tract is extremely rare.We report herein a case of osteoblastic osteosarcoma with exceptionally unique features: sporadic lung metastases and delayed metastases to the stomach and the jejunum with long-term survival. She received multiple operations and chemotherapies, but consequently died of peritoneal dissemination. A review of the literature on osteosarcoma metastasis to the gastrointestinal tract is presented.This patient was very unusual in terms of a long-term survival and metastatic sites, suggesting the importance of vigilance and thorough follow-up for patients with conventional osteosarcoma.

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“… 1 , 2 There are several case reports of hematemesis caused by stomach metastasis from renal cell cancer, lung cancer, and osteosarcoma. 2 , 10 …”

Section: Discussionmentioning

confidence: 99%

Upper Gastrointestinal Bleeding as a Manifestation of Metastasis from Laryngeal Cancer

Singh

Nazeer

Thakur

et al. 2015

ACG Case Reports Journal

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Metastasis of osteosarcoma to stomach made clinically evident by hematemesis: a case report

Cited by 10 publications

References 14 publications

Neoadjuvant and adjuvant chemotherapy with doxorubicin and ifosfamide for bone sarcomas in adult and older patients

Neoadjuvant and adjuvant chemotherapy with doxorubicin and ifosfamide for bone sarcomas in adult and older patients

Long-term survival after sporadic and delayed metastases of conventional osteosarcoma

Upper Gastrointestinal Bleeding as a Manifestation of Metastasis from Laryngeal Cancer

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