Osteoporotic sheep mandibular model for comparative alveolar bone healing research

Sirak, Sergey; Shchetinin, Evgeny; Bobryshev, Dmitry; Fritsch, Tilman; Giesenhagen, Bernd; Petrosyan, Gregory; Grimm, Wolf-Dieter

doi:10.14300/mnnc.2017.12091

Cited by 4 publications

(6 citation statements)

References 13 publications

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“…Животных разделили на основную (10) и контрольную (4) группы. Способ создания экспериментальной модели остеопороза овец осуществляли по установленному протоколу [10].…”

Section: оригинальные исследованияunclassified

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Immunohistochemical evaluation of changes in periodontal tissues in experimental animals with bone skeleton osteoporosis

Sirak¹,

Rubnikovich²,

Shchetinin³

et al. 2019

Medical news of the North Caucasus

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1 stavropol state medical university, russian Federation 2 medical academy of Postgraduate education, minsk, republic Belarus 3 Kuban state Мedical university, Krasnodar, russian Federation изложены результаты исследований по разработке модели остеопороза у экспериментальных животных с последующим анализом картины иммунного ответа тканей пародонта через 90 и 180 суток после начала формирования модели. результаты исследования показали, что уменьшение числа ЕК-клеток в сочетании с увеличением т-клеточной популяции (CD3+, CD4+, CD8+) отражает усиленный иммунный ответ в условиях повышенной антигенной нагрузки при остеопорозе. При этом количественные показатели В-клеток, как показали проведенные исследования, остаются без изменений. Ключевые слова: остеопороз, пародонтит, иммунный ответ, экспериментThe materials of the article contain data on the development of a model of osteoporosis in experimental animals, followed by a detailed description of the immune response of periodontal tissues 90 and 180 days after the beginning of the model formation. The results of the study showed that the decrease in the number of EC cells in combination with an increase in the T-cell population (CD3+, CD4+, CD8+) reflects an enhanced immune response in conditions of increased antigenic load in osteoporosis. At the same time, the quantitative indicators of B cells, as shown by the studies, remain unchanged.

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Section: оригинальные исследованияunclassified

“…У остеопорозных животных их количество увеличивалось до 20-25 на 100 эпителиоцитов уже к 90-м суткам моделирования (рис. [2][3][4][5][6][7][8][9][10].…”

Section: оригинальные исследованияunclassified

Immunohistochemical evaluation of changes in periodontal tissues in experimental animals with bone skeleton osteoporosis

Sirak¹,

Rubnikovich²,

Shchetinin³

et al. 2019

Medical news of the North Caucasus

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“…Экспериментальная медицина О птимизация процессов репаративной регенерации костной ткани имеет ключевое значение в экспериментальной и клинической практике [1,2,3]. Среди факторов экзогенной и эндогенной природы, которые могут способствовать регенерации кости, выделяются актуальностью изучения различные фармацевтические композиции, способы и материалы, в том числе наноматериалы [2,3,4,5].…”

Section: оригинальные исследованияunclassified

Possibilities of using of nanocrystalline CeO2 for bone tissue defects

Lukina¹,

Лукин²,

Baranchikov³

et al. 2018

Medical news of the North Caucasus

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“…For the second stage of the study, 10 sheep were divided into two groups: basic (six animals) and control (four animals). In the main group, an experimental model of OP was induced under general anesthesia (Zoletil 50); ovariectomy was performed, followed by intramuscular injection of dexamethasone for 3 months [9]. Tissue collection was performed under general anesthesia in the area of the lower incisors (hooks), by isolating DAS under general anesthesia after 90 days, 180 days, and 1 year after the start of the experiment.…”

Section: ключевые слова: остеопороз пародонтит эксперимент эндотелийmentioning

confidence: 99%

The histochemical features of the endothelium of the tooth-alveolar complex in inflammation and osteoporosis

Vladimirivich¹,

Vyacheslavovich²,

Bykov³

et al. 2018

Medical news of the North Caucasus

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Ставропольский государственный медицинский университет, российская Федерация 2 Кубанский государственный медицинский университет, Краснодар, российская Федерация The results of immunohistochemical studies of the pulpal state and vascular endothelium of the dental alveolar complex are presented in the experimental modeling of periodontitis and osteoporosis in sheep. The endothelial structural parameters of PD in animals in the gums of the upper and lower jaws differ and affect the length, thickness of cells, number of mitochondria, Golgi complex, reticulum of the endothelium, relationship between the nucleus and cytoplasm, and amount of heterochromatin in the nucleus. In periodontitis, pathological changes are noted in the endothelial circle, as well as in pericytes; this is manifested by a complex vascular-tissue reaction of the microcirculatory bed of periodontal tissues with a violation of the rheological properties of the blood, combined with the formation of exudate and an inflammatory cell infiltrate. In the early period after the formation of the model of experimental osteoporosis, slight thickening and straightening were observed in the Korff fibers; at 180 days, the APhF exhibited a more linear structure, occasionally forming a finely mottled network that resembled a mosquito net. At 1 year of observation, there was a lack of Korff fibers in the primary substance of the pulp, and significant thickening of the argyrophilic membranes in the vascular endothelium; these are signs of impairment in the metabolism of the tooth pulp.

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Osteoporotic sheep mandibular model for comparative alveolar bone healing research

Cited by 4 publications

References 13 publications

Immunohistochemical evaluation of changes in periodontal tissues in experimental animals with bone skeleton osteoporosis

Immunohistochemical evaluation of changes in periodontal tissues in experimental animals with bone skeleton osteoporosis

Possibilities of using of nanocrystalline CeO2 for bone tissue defects

The histochemical features of the endothelium of the tooth-alveolar complex in inflammation and osteoporosis

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