Osteoporosis and the Duration of Coca•Cola Consumption Relationship in Female Albino Rats

Abstract

Coca-cola beverage is one of the risk factors resulting in calcium deficiencies and an increased risk of osteoporosis in rats. The objective of this study is the comparing between five and seven months of coca-cola consumption on osteoporosis markers. The obtained data suggested that orally coca-cola consumption (5ml/Kg/day) cause a significant increase in minerals (calcium and phosphorus) level, in both serum and urine while a significant decrease in the level of these minerals in bone was recorded specially in seven months rats group. At the same time, significant increases in serum and urine creatinine, urea and creatinine ratio as well as parathyroid hormone level, while a decrease in the level of calcitonine as well as in the total protein content were observed. In addition, a significant increase in the level of bone marker enzymes (alkaline and acid phosphatase) activity was recorded, indicating an increase in bone turnover rate. A significant increase was observed in femur water content in rats received cocacola, meanwhile, bone mineral density was significantly decreased. All these parameters are more pronounced at seven months group than those of five months only. Thus, it was concluded that the long-term consumption of coca-cola is strongly associated with the development of osteoporosis evidenced by the occurred changes in the estimated bone marker parameters.

Effect of Quercetin on Alveolar Bone Structure of Rats Subjected to Coca-Cola Consumption: Histological and Ultrastructural Study

“…These EDX results are supported by previous study that explained that excessive soft drink consumption have been found to be associated with low BMD and bone fractures. Decrease in bone minerals (calcium and phosphorus) accompanied with an increase in their levels in serum and urine plays a major role in the genesis of Coca-Cola-associated bone loss (4) . Moreover, Garcia et al recorded subsequent hypocalcaemia and loss of femoral BMD in ovaryectomized rats received cola (24) .…”

“…Therefore, increased phosphoric acid and caffeine content in Coca-Colas are responsible for the increase in the acidity in the body, which in consequently affect the Ca/P ratio and bone mineral content. Moreover, soft drinks rich in caffeine, phosphoric acid, and fructose leads to interference with Ca absorption contributing to Ca imbalance leading to more Ca loss (4) . Prolonged intake of caffeinated and decaffeinated Coca-Cola drinks leads to bone resorption in humans with hazardous effects on the protein intake.…”