Osteonecrosis of the jaws: a review and update in etiology and treatment

Abstract

Selecting an appropriate therapy for osteonecrosis of the jaws management based on current literature is a rational decision that can help lead to a proper treatment plan.

Bisphosphonate Induced Osteonecrosis of the Jaws: Our Clinical Experience at King Hussein Medical Center, Amman, Jordan

“…Similar findings were reported by Kos et al 10 in his series of 34 BIONJ patients, where only three patients lack an identifiable triggering factor.It is believed that patients who develop BIONJ spontaneously are more likely to have recurrences compared to patients who develop BIONJ after a surgical procedure. 1 The only refractory case in the present series has developed the disease spontaneously without any triggering factor.…”

“…3 Guilherme in his review article reviewed in details the possible treatment approaches for BIONJ reported in the literature in the last few years, In his data comparison he found that most reported studies in the literature include antibiotic therapy is more efficient for the management of BIONJ lesions when used in conjunction with bone surgery or debridement and hyperbaric oxygen therapy (HBO), which can induce collagen synthesis, angiogenesis and epithelization as a result of the increase in tissue oxygen tension. 1 In the present study HBO was not used as a treatment modality because this facility was not available in our region.…”

“…Antiresorptive medications such as BP became very popular in the last few decades due to their role in the therapeutic protocol of metastatic bony malignancies, such as multiple myeloma, breast, and prostate cancer, as well as for treatment of metabolic bony diseases, such as osteoporosis and Paget's disease. 1 Bisphosphonates interrupt the mevalonate branch pathway, which is vital to the structural integrity and survival of osteoclasts, by inhibition of the farnesyl synthetase enzyme. 2 It is used in medicine via two routes; intravenous (IV) and oral routes.…”

Influence of bisphosphonates at orthodontic movement

“…1,2,6,7 In clinical terms, the overall effect of these agents is the increase in bone mass, reduction of hypercalcemia, stabilization of bone pathologies, improvement in bone strength and the risk reduction of pathological fracture. 8,9 The aging of the population, exposes the surgeon dentist each day more to care for this group with osteoporosis, therefore, it is up to the orthodontist to be informed of the potential impact of this class of drugs in our patients.…”

Relato De Experiência Em Um Posto De Coleta De Leite Materno: Ações Educativas

“…inhibitors of bone resorption and are widely used to treat different bone diseases or their complications, including osteoporosis, Paget's disease, Multiple Myeloma, Metastatic bone lesions associated with prostate câncer, breast cancer and other cancers, as well as osteogenesis imperfecta and idiopathic or steroid-induced juvenile osteoporosis. By reducing the speed of bone resorption, bisphosphonates are effective in preventing bone metastases and in reducing hypercalcemia caused by malignant tumors(MORAES, SILVA, 2015;MARQUES, 2015;RIBOEIRA, 2018).…”